Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Margarita Espona-Fiedler"'
Autor:
Margarita Espona-Fiedler, Pilar Manuel-Manresa, Cristina Benítez-García, Pere Fontova, Roberto Quesada, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 97 (2022)
Metastasis is the primary cause of death in cancer patients. Many current chemotherapeutic agents only show cytotoxic, but not antimetastatic properties. This leads to a reduction in tumor size, but allows cancer cells to disseminate, which ultimatel
Externí odkaz:
https://doaj.org/article/fdb43ea166df4a6d8d5110b13090a1b5
Autor:
Ali Hosseini, Margarita Espona-Fiedler, Vanessa Soto-Cerrato, Roberto Quesada, Ricardo Pérez-Tomás, Victor Guallar
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57562 (2013)
Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently under preclinical and clinical trials. The molecular target(s) of these agents, however, is an open question. Combining
Externí odkaz:
https://doaj.org/article/c3ff65cb228c4be587d5f0ab79cad5b9
Autor:
Jennifer Ferris, Alex J. McIntyre, Margarita Espona-Fiedler, Victoria Coyle, Daniel B. Longley, Jamie Z. Roberts, Nyree Crawford, Simon S. McDade, Mark Wappett, Claudia Hamilton, Caitriona Holohan
Publikováno v:
Cell Death Discovery, Vol 6, Iss 1, Pp 1-14 (2020)
Cell Death Discovery
Cell Death Discovery
Pevonedistat (MLN4924), a selective inhibitor of the NEDD8-activating enzyme E1 regulatory subunit (NAE1), has demonstrated significant therapeutic potential in several malignancies. Although multiple mechanisms-of-action have been identified, how ML
Autor:
Joel S. Riley, Hajrah Khawaja, Jennifer Fox, Joanna Majkut, Caitriona Holohan, Luke M Humphreys, Jennifer Ferris, Margarita Espona-Fiedler, Daniel B. Longley, Jamie Z. Roberts, Catherine A. Higgins, Paul N. Moynagh, Nyree Crawford, Emma Evergren, Simon S. McDade, Tamas Sessler
Publikováno v:
Roberts, J Z, Holohan, C, Sessler, T, Fox, J, Crawford, N, Riley, J S, Khawaja, H, Majkut, J, Evergren, E, Humphreys, L M, Ferris, J, Higgins, C, Espona-Fiedler, M, Moynagh, P, McDade, S S & Longley, D B 2020, ' The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) ', Cell Death and Differentiation, vol. 27, pp. 2726–2741 . https://doi.org/10.1038/s41418-020-0539-7
TRAIL-R2 (DR5) is a clinically-relevant therapeutic target and a key target for immune effector cells. Herein, we identify a novel interaction between TRAIL-R2 and the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 Ubiquitin Ligase complex containing Skp2
Autor:
Jamie Z, Roberts, Caitriona, Holohan, Tamas, Sessler, Jennifer, Fox, Nyree, Crawford, Joel S, Riley, Hajrah, Khawaja, Joanna, Majkut, Emma, Evergren, Luke M, Humphreys, Jennifer, Ferris, Catherine, Higgins, Margarita, Espona-Fiedler, Paul, Moynagh, Simon S, McDade, Daniel B, Longley
Publikováno v:
Cell Death and Differentiation
TRAIL-R2 (DR5) is a clinically-relevant therapeutic target and a key target for immune effector cells. Herein, we identify a novel interaction between TRAIL-R2 and the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 Ubiquitin Ligase complex containing Skp2
Publikováno v:
The FEBS journal. 285(22)
One of the classic hallmarks of cancer is disruption of cell death signalling. Inhibition of cell death promotes tumour growth and metastasis, causes resistance to chemo- and radiotherapies as well as targeted agents, and is frequently due to overexp
Autor:
Margarita Espona-Fiedler, Wenan Qiang, Elizabeth C. Bertsch, Beihua Kong, Takeshi Kurita, Khush Mittal, Stacy A. Druschitz, Qing Zhang, Jian-Jun Wei, Yu Liu
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Recent identification of somatic MED12 mutations in most uterine leiomyomas brings a new venue for the study of the tumorigenesis of leiomyomas. We are particularly interested in the correlation of MED12 and HMGA2 gene products in leiomyomas and leio
Autor:
Vanessa Soto-Cerrato, Durvanei Augusto Maria, Ricardo Pérez-Tomás, José Agustín Quincoces Suárez, Margarita Espona-Fiedler, Fernanda Faião-Flores
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Melanoma is one of the most aggressive types of skin cancer and its incidence rate is still increasing. All existing treatments are minimally effective. Consequently, new therapeutic agents for melanoma treatment should be developed. The DM-1 compoun
Autor:
Luís Korrodi-Gregório, Sandra Rebelo, Odete A. B.da Cruz Silva, Margarida Fardilha, Juliana Felgueiras, Jo~ao Figueiredo, Ricardo Pérez-Tomás, Edgar F. da Cruz e Silva, Margarita Espona-Fiedler, Sara L. C. Esteves
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Dipòsit Digital de la UB
Universidad de Barcelona
Reversible protein phosphorylation is a central regulatory mechanism of cell function. Deregulation of the balanced actions of protein kinases and phosphatases has been frequently associated with several pathological conditions, including cancer. Man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532d33bc3726d40185e9107ec08e9f8e
http://hdl.handle.net/2445/108794
http://hdl.handle.net/2445/108794
Autor:
Yu Liu, Vanida Ann Serna, Zhaojian Liu, Margarita Espona-Fiedler, Stacy A. Druschitz, Takeshi Kurita, Wenan Qiang, Jian-Jun Wei
Publikováno v:
Endocrinology. 155(3)
Uterine leiomyomata (LMs) are the most common tumor affecting the female reproductive organs. The most notable pathophysiologic feature of this tumor is the excessive accumulation of rigid extracellular matrix (ECM) composed mainly of collagen types