Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Margarita Carmona"'
Autor:
Núria Benseny-Cases, Elena Álvarez-Marimon, Ester Aso, Margarita Carmona, Oxana Klementieva, Dietmar Appelhans, Isidre Ferrer, Josep Cladera
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance
Externí odkaz:
https://doaj.org/article/d8a5ad123a7a4b33aa19c03be9c3699c
Autor:
Pol Andrés-Benito, África Flores, Sara Busquet-Areny, Margarita Carmona, Karina Ausín, Paz Cartas-Cejudo, Mercedes Lachén-Montes, José Antonio Del Rio, Joaquín Fernández-Irigoyen, Enrique Santamaría, Isidro Ferrer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6559 (2023)
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with WT mice, tau-KO mice display
Externí odkaz:
https://doaj.org/article/45158ab882c74954b0bead9db368f3d2
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15940 (2022)
Heterozygous hTau mice were used for the study of tau seeding. These mice express the six human tau isoforms, with a high predominance of 3Rtau over 4Rtau. The following groups were assessed: (i) non-inoculated mice aged 9 months (n = 4); (ii) Alzhei
Externí odkaz:
https://doaj.org/article/3b8ab4b6e708425c94429f0194e4c705
Autor:
Isidro Ferrer, Pol Andrés-Benito, Paula Garcia-Esparcia, Irene López-Gonzalez, Diego Valiente, Mónica Jordán-Pirla, Margarita Carmona, Julia Sala-Jarque, Vanessa Gil, José Antonio del Rio
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4789 (2022)
Alzheimer’s disease (AD) and other tauopathies are common neurodegenerative diseases in older adults; in contrast, abnormal tau deposition in neurons and glial cells occurs only exceptionally in children. Sarkosyl-insoluble fractions from sporadic
Externí odkaz:
https://doaj.org/article/2cdf1dce5b9d43068ac3f0d31a94c524
Autor:
Pol Andrés-Benito, Margarita Carmona, Mónica Jordán, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antoni del Rio, Isidro Ferrer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 718 (2022)
Several studies have demonstrated the different characteristics of tau seeding and spreading following intracerebral inoculation in murine models of tau-enriched fractions of brain homogenates from AD and other tauopathies. The present study is cente
Externí odkaz:
https://doaj.org/article/6e92fc175d6d46aaa27344f89b51cda2
Autor:
Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn, Andre Fischer, Pawel P. Liberski, Juan Maria Torres, Isidre Ferrer, Inga Zerr
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-20 (2017)
Abstract Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathoge
Externí odkaz:
https://doaj.org/article/2e50321168ab46359a8ddcd179c4d0d2
Autor:
Isidro Ferrer, Meritxell Aguiló García, Margarita Carmona, Pol Andrés-Benito, Benjamin Torrejón-Escribano, Paula Garcia-Esparcia, José Antonio del Rio
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Introduction: Human tau seeding and spreading occur following intracerebral inoculation into different gray matter regions of brain homogenates obtained from tauopathies in transgenic mice expressing wild or mutant tau, and in wild-type (WT) mice. Ho
Externí odkaz:
https://doaj.org/article/9191bdf58024473ca2f73f668c3598f0
Autor:
Isabel M. Guijarro, Moisés Garcés, Pol Andrés-Benito, Belén Marín, Alicia Otero, Tomás Barrio, Margarita Carmona, Isidro Ferrer, Juan J. Badiola, Marta Monzón
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 204 (2021)
The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexametha
Externí odkaz:
https://doaj.org/article/0a23dc48962242a480362e13fec00973
Autor:
Isabel M. Guijarro, Moisés Garcés, Pol Andrés-Benito, Belén Marín, Alicia Otero, Tomás Barrio, Margarita Carmona, Isidro Ferrer, Juan J. Badiola, Marta Monzón
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3231 (2020)
Neuroinflammation has been correlated with the progress of neurodegeneration in many neuropathologies. Although glial cells have traditionally been considered to be protective, the concept of them as neurotoxic cells has recently emerged. Thus, a maj
Externí odkaz:
https://doaj.org/article/ce54c59372664af6a64c00142aac4dfc
Autor:
Paula Garcia-Esparcia, Daniela Diaz-Lucena, Marina Ainciburu, Benjamin Torrejón-Escribano, Margarita Carmona, Franc Llorens, Isidro Ferrer
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and t
Externí odkaz:
https://doaj.org/article/cc40ea3f164c421b956102235096edd6