Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Margarita Avdiushko"'
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Akademický článek
Recombinant Protein Vaccines Formulated with Enantio-Specific Cationic Lipid R-DOTAP Induce Protective Cellular and Antibody-Mediated Immune Responses in Mice
Autor: Siva K. Gandhapudi, Hua Shi, Martin R. Ward, John Peyton Bush, Margarita Avdiushko, Karuna Sundarapandiyan, Lauren V. Wood, Mania Dorrani, Afsheen Fatima, Joe Dervan, Frank Bedu-Addo, Greg Conn, Ted M. Ross, Jerold G. Woodward
Publikováno v: Viruses, Vol 15, Iss 2, p 432 (2023)
Adjuvants are essential components of subunit vaccines added to enhance immune responses to antigens through immunomodulation. Very few adjuvants have been approved for human use by regulatory agencies due to safety concerns. Current subunit vaccine
Externí odkaz: https://doaj.org/article/34c62344fca4487da98e87adc6efc885
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AUPHOS, A NOVEL THERAPEUTIC THAT IMPROVES MITOCHONDRIAL FUNCTION AND AMELIORATES CHRONIC COLITIS
Autor: Rana Mohamed, James Warinner, Lesley Wempe, Margarita Avdiushko, Tatiana Goretsky, Jong Kim, Ahmed Abomhya, Goo Lee, Samuel Awuah, Terrence Barrett, Neeraj Kapur
Publikováno v: Gastroenterology. 162:S2-S3
BACKGROUND Inflammatory Bowel Disease (IBD) involves an interplay of gut microbiota, intestinal epithelium and immune responses. Recent data suggest that decreased mitochondrial gene function plays an active role in the pathophysiology of active coli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823215561aa872df299dd0d88deec4ee
https://doi.org/10.1053/j.gastro.2021.12.011
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AUPHOS, A 'FIRST-IN CLASS' ORAL AGENT FOR CORRECTING METABOLIC DYSFUNCTION IN IBD
Autor: Lesley Wempe, Rana Mohamed, James Warinner, Tatiana Goretsky, Margarita Avdiushko, Jong Kim, Ahmed Abomhya, Goo Lee, Samuel Awuah, Terrence Barrett, Neeraj Kapur
Publikováno v: Gastroenterology. 162:S2
BACKGROUND Mucosal repair is the goal of medical therapy in IBD. Prospective inception cohort pediatric studies suggest that suppression of mitochondrial genes lead to unfavorable clinical outcomes in ulcerative colitis (UC) and Crohn’s disease (CD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5a6ff79c4dad859594e9af58f41942
https://doi.org/10.1053/j.gastro.2021.12.010
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NEW OXPHOS REGULATING COMPOUND – AUPHOS – INCREASES MITOCHONDRIAL COMPLEXES EXPRESSION IN MURINE AND HUMAN INTESTINAL EPITHELIAL CELLS
Autor: Ahmed Elsayed, Ahmed Abomhya, Margarita Avdiushko, Neeraj Kapur, Samuel Awuah, Terrence Barrett, Tatiana Goretsky
Publikováno v: Gastroenterology. 162:S51
INTRODUCTION Mitochondrial dysfunction in intestinal epithelial cells (IEC) is a critical driver in the failure to heal chronic ulceration in IBD(1). OXPHOS is important for differentiation and cell polarity in repairing IEC(2,3). The development of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c2e01798ec7e1b0f5984fb111cafb3
https://doi.org/10.1053/j.gastro.2021.12.106
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OXPHOS DRIVES CRYPT FISSIONING REQUIRED FOR HEALING OF IBD ULCERS
Autor: Ahmed Abomhya, Tatiana Goretsky, Neeraj Kapur, Courtney Perry, Margarita Avdiushko, Emily Bradford, Terrence Barrett
Publikováno v: Inflammatory Bowel Diseases. 28:S52-S52
INTRODUCTION The failure of ulcers healing is a characteristic feature of IBD. Mitochondrial dysfunction in intestinal epithelial cells (IEC) occurs in IBD and is linked to worse clinical outcomes in pediatric Crohn’s and ulcerative colitis (Kugrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bd2c50843e3d3223fe9299178d32a5
https://doi.org/10.1093/ibd/izac015.082
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Plný text Recenzováno Digitální knihovna AV ČR
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