Data from Validation of the 16-Gene Recurrence Score in Patients with Locoregional, High-Risk Renal Cell Carcinoma from a Phase III Trial of Adjuvant Sunitinib

Autor: Alain Ravaud, Robert J. Motzer, Michael Staehler, Olga Valota, Xun Lin, Rachel Li, Phillip G. Febbo, Audrey D. Goddard, Dejan Knezevic, Margarita Lopatin, Christer Svedman, Ahmed Magheli, Jean-Francois Martini, Bernard Escudier, Brian I. Rini

Purpose: Adjuvant sunitinib prolonged disease-free survival (DFS; HR, 0.76) in patients with locoregional high-risk renal cell carcinoma (RCC) in the S-TRAC trial (ClinicalTrials.gov NCT00375674). The 16-gene Recurrence Score (RS) assay was previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5decd5cf3fd0ebc7b81f4433c5843aec
https://doi.org/10.1158/1078-0432.c.6527442.v1

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Autor: M.C. Liu, G.R. Oxnard, E.A. Klein, C. Swanton, M.V. Seiden, Minetta C. Liu, Geoffrey R. Oxnard, Eric A. Klein, David Smith, Donald Richards, Timothy J. Yeatman, Allen L. Cohn, Rosanna Lapham, Jessica Clement, Alexander S. Parker, Mohan K. Tummala, Kristi McIntyre, Mikkael A. Sekeres, Alan H. Bryce, Robert Siegel, Xuezhong Wang, David P. Cosgrove, Nadeem R. Abu-Rustum, Jonathan Trent, David D. Thiel, Carlos Becerra, Manish Agrawal, Lawrence E. Garbo, Jeffrey K. Giguere, Ross M. Michels, Ronald P. Harris, Stephen L. Richey, Timothy A. McCarthy, David M. Waterhouse, Fergus J. Couch, Sharon T. Wilks, Amy K. Krie, Rama Balaraman, Alvaro Restrepo, Michael W. Meshad, Kimberly Rieger-Christ, Travis Sullivan, Christine M. Lee, Daniel R. Greenwald, William Oh, Che-Kai Tsao, Neil Fleshner, Hagen F. Kennecke, Maged F. Khalil, David R. Spigel, Atisha P. Manhas, Brian K. Ulrich, Philip A. Kovoor, Christopher Stokoe, Jay G. Courtright, Habte A. Yimer, Timothy G. Larson, Charles Swanton, Michael V. Seiden, Steven R. Cummings, Farnaz Absalan, Gregory Alexander, Brian Allen, Hamed Amini, Alexander M. Aravanis, Siddhartha Bagaria, Leila Bazargan, John F. Beausang, Jennifer Berman, Craig Betts, Alexander Blocker, Joerg Bredno, Robert Calef, Gordon Cann, Jeremy Carter, Christopher Chang, Hemanshi Chawla, Xiaoji Chen, Tom C. Chien, Daniel Civello, Konstantin Davydov, Vasiliki Demas, Mohini Desai, Zhao Dong, Saniya Fayzullina, Alexander P. Fields, Darya Filippova, Peter Freese, Eric T. Fung, Sante Gnerre, Samuel Gross, Meredith Halks-Miller, Megan P. Hall, Anne-Renee Hartman, Chenlu Hou, Earl Hubbell, Nathan Hunkapiller, Karthik Jagadeesh, Arash Jamshidi, Roger Jiang, Byoungsok Jung, TaeHyung Kim, Richard D. Klausner, Kathryn N. Kurtzman, Mark Lee, Wendy Lin, Jafi Lipson, Hai Liu, Qinwen Liu, Margarita Lopatin, Tara Maddala, M. Cyrus Maher, Collin Melton, Andrea Mich, Shivani Nautiyal, Jonathan Newman, Joshua Newman, Virgil Nicula, Cosmos Nicolaou, Ongjen Nikolic, Wenying Pan, Shilpen Patel, Sarah A. Prins, Richard Rava, Neda Ronaghi, Onur Sakarya, Ravi Vijaya Satya, Jan Schellenberger, Eric Scott, Amy J. Sehnert, Rita Shaknovich, Avinash Shanmugam, K.C. Shashidhar, Ling Shen, Archana Shenoy, Seyedmehdi Shojaee, Pranav Singh, Kristan K. Steffen, Susan Tang, Jonathan M. Toung, Anton Valouev, Oliver Venn, Richard T. Williams, Tony Wu, Hui H. Xu, Christopher Yakym, Xiao Yang, Jessica Yecies, Alexander S. Yip, Jack Youngren, Jeanne Yue, Jingyang Zhang, Lily Zhang, Lori (Quan) Zhang, Nan Zhang, Christina Curtis, Donald A. Berry

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology

Background Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3b4e6c4dc63db12f3e66da9ddf3798
https://doi.org/10.1016/j.annonc.2020.02.011

The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice

Autor: Richard Whittington, Margarita Lopatin, Geoffrey R. Oxnard, Catherine R. Marinac, Bruce Taylor, Eric A. Klein, Eric T. Fung, Charles H. McDonnell, Lincoln Nadauld, Deborah Schrag, Andrew G. Hudnut, Jafi A. Lipson, Tomasz M. Beer, Karen C. Chung, Rita Shaknovich, Minetta C. Liu

Publikováno v: Cancers, Vol 13, Iss 3501, p 3501 (2021)
Cancers
Volume 13
Issue 14

To examine the extent of the evaluation required to achieve diagnostic resolution and the test performance characteristics of a targeted methylation cell-free DNA (cfDNA)-based multi-cancer early detection (MCED) test, ~6200 participants ≥50 years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751c3c0233624e651cd0295772f325d0
https://www.mdpi.com/2072-6694/13/14/3501

A prespecified interim analysis of the PATHFINDER study: Performance of a multicancer early detection test in support of clinical implementation

Autor: Eric T. Fung, Tomasz M. Beer, Lincoln Nadauld, Margarita Lopatin, Minetta C. Liu, Charles H. McDonnell, Deborah Schrag, Karen Chung, Robert Lawrence Reid, Eric A. Klein

Publikováno v: Journal of Clinical Oncology. 39:3070-3070

3070 Background: A multi-cancer early detection (MCED) test that uses targeted methylation-based cfDNA technology to detect cancer and predict cancer signal origin (CSO) has potential to efficiently identify malignancies for which effective screening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e42a75f2f907e88d9e28bdcd3be22a14
https://doi.org/10.1200/jco.2021.39.15_suppl.3070

Tu1836 TUMOR AREA AND MICROSCOPIC EXTENT OF INVASION DETERMINE CIRCULATING TUMOR CELL-FREE DNA FRACTION IN PLASMA AND DETECTABILITY OF COLORECTAL CANCER

Autor: Tony J. Wu, Samuel Gross, Nan Zhang, Joerg Bredno, Brian C. Allen, John F. Beausang, Earl Hubbell, Alexander P. Fields, Hai Liu, Jackie Brooks, Oliver Venn, Lori Zhang, Alex Aravanis, Margarita Lopatin, Arash Jamshidi, Xiaoji Chen, Anne-Renee Hartman, Jafi A. Lipson, Qinwen Liu

Publikováno v: Gastroenterology. 158:S-1181

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13563faf40b794e937ed88e2673f849d
https://doi.org/10.1016/s0016-5085(20)33623-4