Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Margarita, Camara"'
Autor:
Adem C. Koksal, Chelsea C. Boo, Margarita Camara, Lily Cheng, Nicholas Holoweckyj, Virginia N. Takahashi, Carolina S. Caceres, Andriani C. Patera, Antonio DiGiandomenico, Christopher Morehouse, Shonda Hawkins, Taylor S. Cohen, Melissa de los Reyes, Ashley E. Keller, Bret R. Sellman, Sonja Hess, Mark Pelletier, Ajitha Thanabalasuriar, Marcello Marelli, Abby J. Chiang, Aaron A Berlin
Publikováno v:
Science Advances. 7
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury. These neutrophils expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302b619adf0ba39ca10d865184c5e43f
https://doi.org/10.1126/sciadv.abd9436
https://doi.org/10.1126/sciadv.abd9436
Autor:
Ajitha, Thanabalasuriar, Abby J, Chiang, Christopher, Morehouse, Margarita, Camara, Shonda, Hawkins, Ashley E, Keller, Adem C, Koksal, Carolina S, Caceres, Aaron A, Berlin, Nicholas, Holoweckyj, Virginia N, Takahashi, Lily, Cheng, Melissa, de Los Reyes, Mark, Pelletier, Andriani C, Patera, Bret, Sellman, Sonja, Hess, Marcello, Marelli, Chelsea C, Boo, Taylor S, Cohen, Antonio, DiGiandomenico
Publikováno v:
Science Advances
Neutrophils abandon infection control during wound repair.
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dadb20c85d74981819d8a619237afbcb
https://pubmed.ncbi.nlm.nih.gov/33674305
https://pubmed.ncbi.nlm.nih.gov/33674305
Autor:
M. Margarita Camara, C. Kendall Stover, Wei Zhao, Joshua T. Thaden, Antonio DiGiandomenico, Linda G. Otterson, Norah J. Shire, Vance G. Fowler, Caitlin M. Guenther, Mike Huband, Paul Warrener, Ashley E. Keller
Publikováno v:
Journal of Infectious Diseases. 213:640-648
Background. The type 3 secretion protein PcrV and Psl exopolysaccharide are promising therapeutic antibody targets against Pseudomonas aeruginosa. We examined P. aeruginosa bloodstream infection (BSI) isolates for the ability to express PcrV and Psl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8c16c68d847dab765137f9adf3040
https://doi.org/10.1093/infdis/jiv436
https://doi.org/10.1093/infdis/jiv436
Autor:
Fabrizia Zatta, Maria Margarita Camara, Xiaodong Xiao, Elisabetta Cameroni, Davide Corti, Jessica Bonnell, Martina Beltramello, C. Kendall Stover, Antonio Lanzavecchia, JoAnn Suzich, Siro Bianchi, Meghan Pennini, Elena Semenova, Paul Warrener, Romana Cvitkovic, Anna De Marco, Wei Zhao, Mark Pelletier, Antonio DiGiandomenico, Qun Wang
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust antibacterial vaccines have prevented and reduced resistance suggesting a pivotal role for immunity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2c27fabb75c269735e01ef307abd1e
https://pubmed.ncbi.nlm.nih.gov/29222409
https://pubmed.ncbi.nlm.nih.gov/29222409
Autor:
Ralph Minter, Ashley E. Keller, Vignesh Venkatraman, Michael P. McCarthy, Maria Margarita Camara, Sandrine Guillard, JoAnn Suzich, Lutz Jermutus, Peter Ravn, C. Kendall Stover, Qun Wang, Mladen Tomich, Paul Warrener, Jessica Bonnell, David Melnick, Jia Lin, Melissa Hamilton, Randall S. MacGill, Antonio DiGiandomenico
Publikováno v:
The Journal of Experimental Medicine
A human antibody facilitates opsonophagocytic killing, inhibits attachment of Pseudomonas aeruginosa, and exerts protective effects in several animal models of P. aeruginosa infection.
Pseudomonas aeruginosa is a leading cause of hospital-associ
Pseudomonas aeruginosa is a leading cause of hospital-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609e68164aecd3312632aa76050049fe
https://doi.org/10.1084/jem.20120033
https://doi.org/10.1084/jem.20120033
Autor:
Stan Mitelman, James Fleming, Bridget Finnerty, Maria Carolina Tuma, Paul Kussie, Asra Malikzay, Margarita Camara, David Surguladze, Eugene L. Piatnitski Chekler, Xiaohu Ouyang, James R. Tonra, Jacqueline Doody
Publikováno v:
Translational Oncology. 3(5):318-325
Microtubules are a well-validated target for anticancer therapy. Molecules that bind tubulin affect dynamic instability of microtubules causing mitotic arrest of proliferating cells, leading to cell death and tumor growth inhibition. Natural antitubu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff69926fe45c77be8333a1c4bb10514
Autor:
John Gooya, Sudha Swamynathan, Changshou Gao, Michael S. Kinch, Linda Xu, Margarita Camara, Damon L. Meyer, Steven Coats, Peter A. Kiener, Peter D. Senter, Ryan Fleming, Herren Wu, David A. Tice, Christine Fazenbaker, Krista Kinneer, Shenlan Mao, Dowdy Jackson
Publikováno v:
Cancer Research. 68:9367-9374
The EphA2 receptor tyrosine kinase is selectively expressed on the surface of many different human tumors. We have previously shown that tumor cells can be targeted by EphA2 monoclonal antibodies and that these antibodies function, in part, by induci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfb0e5f4892903fd25ec2c813706510
https://doi.org/10.1158/0008-5472.can-08-1933
https://doi.org/10.1158/0008-5472.can-08-1933
Autor:
Alexander S. Kiselyov, Jason Gerlak, Robin L. Rosler, Margarita Camara, James Fleming, Sui Ping Lee, Stan Mitelman, Asra Malikzay, Vatee Pattaropong, Ying Wang, Avdhoot Velankar, Evgueni L. Piatnitski, Leon M. Smith, Julia Winslow Lohman, Xiaoling Chen, Xiaohu Ouyang, David Surguladze, Joel Kawakami, M. Carolina Tuma, Marc Labelle, Jacqueline Doody, Hai-Ying He, Kai Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1191-1196
Oxadiazole derivatives were synthesized and evaluated for their ability to inhibit tubulin polymerization and to cause mitotic arrest in tumor cells. The most potent compounds inhibited tubulin polymerization at concentrations below 1 microM. Lead an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d09b776083064c4c4f8ef3c541b433
https://doi.org/10.1016/j.bmcl.2005.11.094
https://doi.org/10.1016/j.bmcl.2005.11.094
Autor:
Jessica Bonnell, Li Peng, C. Kendall Stover, Maria Margarita Camara, Jingying Zha, Bret R. Sellman, Reena Varkey, Paul Warrener, Kimberly E. Cook, Antonio DiGiandomenico, Partha Chowdury
Publikováno v:
Antimicrobial agents and chemotherapy. 58(8)
Pseudomonas aeruginosa is a major cause of hospital-acquired infections, particularly in mechanically ventilated patients, and it is the leading cause of death in cystic fibrosis patients. A key virulence factor associated with disease severity is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07db459eb4cc5ea45e5becb1cef3ed9e
https://pubmed.ncbi.nlm.nih.gov/24841258
https://pubmed.ncbi.nlm.nih.gov/24841258
Autor:
Hu Liu, Margarita Camara, James R. Tonra, Dhanvanthri S. Deevi, Alexander S. Kiselyov, Yong-Jiang Xu, Wai C. Wong, Hua-Quan Miao, Paul Kussie, Weitao Pan, Elizabeth Navarro, Stan Mitelman
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(2)
A novel class of N-(4-{[4-(1H-benzoimidazol-2-yl)-arylamino]-methyl}-phenyl)-benzamides are described as inhibitors of the endo-beta-glucuronidase heparanase. Among them are N-(4-{[4-(1H-benzoimidazol-2-yl)-phenylamino]-methyl}-phenyl)-3-bromo-4-meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64b4d6822e03afd0eeb54413373399f
https://pubmed.ncbi.nlm.nih.gov/16246551
https://pubmed.ncbi.nlm.nih.gov/16246551