Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Margarida Souto-Carneiro"'
Autor:
Hannah Schindler, Fabienne Lusky, Lea Daniello, Mariam Elshiaty, Lena Gaissmaier, Karolina Benesova, Margarida Souto-Carneiro, Arlou Kristina Angeles, Florian Janke, Florian Eichhorn, Daniel Kazdal, Marc Schneider, Stephan Liersch, Sarah Klemm, Paul Schnitzler, Albrecht Stenzinger, Holger Sültmann, Michael Thomas, Petros Christopoulos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionPD-(L)1 inhibitors (IO) have improved the prognosis of non-small-cell lung cancer (NSCLC), but more reliable predictors of efficacy and immune-related adverse events (irAE) are urgently needed. Cytokines are important effector molecules o
Externí odkaz:
https://doaj.org/article/ef666ed4ec8a4dd9a73f2c5dcfa83e26
Autor:
Jan Leipe, Jessica C Hassel, Hanns-Martin Lorenz, Janine Günther, Manuel Feisst, Leonore Diekmann, Petros Christopoulos, Karolina Gente, Lea Daniello, Julia Will, Victor Olsavszky, M Margarida Souto-Carneiro
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background Rheumatic immune-related adverse events (R-irAEs) occur in 5–15% of patients receiving immune checkpoint inhibitors (ICI) and, unlike other irAEs, tend to be chronic. Herein, we investigate the factors influencing cancer and R-irAEs outc
Externí odkaz:
https://doaj.org/article/2a66029fe121462dbd06630333efd7f8
Autor:
Karolina Benesova, Franziska Viktoria Kraus, Rui A Carvalho, Holger Lorenz, Christian H Hörth, Janine Günther, Karel D Klika, Jürgen Graf, Leonore Diekmann, Timo Schank, Petros Christopoulos, Jessica C Hassel, Hanns-Martin Lorenz, Margarida Souto-Carneiro
Publikováno v:
Annals of the Rheumatic Diseases. 81:1730-1741
ObjectivesRheumatic immune-related adverse events (irAE) such as (poly)arthritis in patients undergoing immune checkpoint inhibitor (ICI) treatment pose a major clinical challenge. ICI therapy improves CD8+T cell (CD8) function, but CD8 contributes t
Autor:
Claudia M. Denkinger, Maike Janssen, Ulrike Schäkel, Julia Gall, Albrecht Leo, Patrick Stelmach, Stefan F. Weber, Johannes Krisam, Lukas Baumann, Jacek Stermann, Uta Merle, Markus A. Weigand, Christian Nusshag, Lars Bullinger, Jens-Florian Schrezenmeier, Martin Bornhäuser, Nael Alakel, Oliver Witzke, Timo Wolf, Maria J. G. T. Vehreschild, Stefan Schmiedel, Marylyn M. Addo, Felix Herth, Michael Kreuter, Phil-Robin Tepasse, Bernd Hertenstein, Mathias Hänel, Anke Morgner, Michael Kiehl, Olaf Hopfer, Mohammad-Amen Wattad, Carl C. Schimanski, Cihan Celik, Thorsten Pohle, Matthias Ruhe, Winfried V. Kern, Anita Schmitt, Hanns-Martin Lorenz, Margarida Souto-Carneiro, Mary Gaeddert, Niels Halama, Stefan Meuer, Hans-Georg Kräusslich, Barbara Müller, Paul Schnitzler, Sylvia Parthé, Ralf Bartenschlager, Martina Gronkowski, Jennifer Klemmer, Michael Schmitt, Peter Dreger, Katharina Kriegsmann, Richard F. Schlenk, Carsten Müller-Tidow
Patients with cancer are at high risk of severe coronavirus disease 2019 (COVID-19), with high morbidity and mortality. Furthermore, impaired humoral response renders severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines less effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9354f3b1c92e5a06f358a09fb158711e
http://edoc.mdc-berlin.de/23008/2/23008suppl.zip
http://edoc.mdc-berlin.de/23008/2/23008suppl.zip
Autor:
Claudia M Denkinger, Maike Janssen, Ulrike Schäkel, Julia Gall, Albrecht Leo, Patrick Stelmach, Stefan F Weber, Johannes Krisam, Lukas Baumann, Jacek Stermann, Uta Merle, Markus Weigand, Lars Bullinger, Jens-Florian Schrezenmeier, Martin Bornhäuser, Nael Alakel, Oliver Witzke, Timo Wolf, Maria Vehreschild, Stefan Schmiedel, Marylyn Addo, Felix Herth, Michael Kreuter, Phil-Robin Tepasse, Bernd Hertenstein, Mathias Hänel, Anke Morgner, Michael Kiehl, Olaf Hopfer, Mohammad-Amen Wattad, Carl Schimanski, Cihan Celik, Thorsten Pohle, Matthias Ruhe, Winfried Kern, Anita Schmitt, Michael Schmitt, Hanns-Martin Lorenz, Margarida Souto-Carneiro, Niels Halama, Stefan Meurer, Hans-Georg Kräusslich, Barbara Müller, Ralf Bartenschlager, Martina Gronkowski, Jennifer Klemmer, Katharina Kriegsmann, Richard Schlenk, Carsten Müller-Tidow
Publikováno v:
Open Forum Infectious Diseases. 9
Background Patients with hematological malignancy or other cancers as well as immunosuppression bear a high risk for severe COVID-19. Monoclonal antibodies (mAb) are efficient at early stages of the disease but may lose potency with new variants. Tri
Autor:
Lina Carvalho, Joana R. M. Gomes, Ludgero C. Tavares, Ana R. Xavier, Karel D. Klika, Rikard Holmdahl, Rui A. Carvalho, M. Margarida Souto-Carneiro
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely
Externí odkaz:
https://doaj.org/article/82ccb458012c4de2a948a0e8b5a952bc
Autor:
Christine Tucher, Konrad Bode, Petra Schiller, Laura Claßen, Carolin Birr, Maria Margarida Souto-Carneiro, Norbert Blank, Hanns-Martin Lorenz, Martin Schiller
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Extracellular vesicles (EVs) are released from nearly all mammalian cells and different EV populations have been described. Microvesicles represent large EVs (LEVs) released from the cellular surface, while exosomes are small EVs (SEVs) released from
Externí odkaz:
https://doaj.org/article/db542ebe06a04932bd761209317df4b5
Autor:
Franziska V. Kraus, Simon Keck, Karel D. Klika, Jürgen Graf, Rui A. Carvalho, Hanns‐Martin Lorenz, M. Margarida Souto‐Carneiro
ObjectivesRA CD8+ T-cells (CD8) maintain their effector pro-inflammatory phenotype by changing their metabolism towards aerobic glycolysis. However, their massive energetic and biosynthetic needs may require additional substrates to furnish this high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eac6ed97246e01687b9f560bb9e45f
https://doi.org/10.1101/2022.09.22.22280236
https://doi.org/10.1101/2022.09.22.22280236
Autor:
Christian Orlik, Karina M. Berschneider, Beate Jahraus, Beate Niesler, Emre Balta, Knut Schäkel, Jutta Schröder-Braunstein, Maria Margarida Souto-Carneiro, Yvonne Samstag
Publikováno v:
Frontiers in immunology. 13
In psoriasis and other inflammatory skin diseases, keratinocytes (KCs) secrete chemokines that attract T cells, which, in turn, cause epidermal hyperplasia by secreting proinflammatory cytokines. To date, it remains unclear whether skin-homing T cell
Autor:
Karolina Benesova, Franziska V. Kraus, Rui A. Carvalho, Leonore Diekmann, Janine Günther, Karel D. Klika, Petros Christopoulos, Jessica C. Hassel, Hanns-Martin Lorenz, M Margarida Souto-Carneiro
ObjectivesRheumatic immune-related adverse events (irAE) such as (poly)arthritis in patients undergoing immune checkpoint inhibitor (ICI) treatment pose a major clinical challenge. ICI-therapy improves CD8+ T cell (CD8) function, but CD8 contribute t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea28a3c10eac9b9149207f42f2074ab8
https://doi.org/10.1101/2022.03.09.22272158
https://doi.org/10.1101/2022.03.09.22272158