Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Margarida Fardilha"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Protein Phosphatase 1 (PP1) is a major serine/threonine phosphatase in eukaryotes, participating in several cellular processes and metabolic pathways. Due to their low substrate specificity, PP1’s catalytic subunits do not exist as free en
Externí odkaz:
https://doaj.org/article/a2d4dcf1069f4e0f86bd661e4b6f6882
Autor:
Pedro O. Corda, Jéssica Moreira, John Howl, Pedro F. Oliveira, Margarida Fardilha, Joana Vieira Silva
Publikováno v:
The World Journal of Men's Health, Vol 42, Iss 1, Pp 71-91 (2024)
Purpose: The advent of proteomics provides new opportunities to investigate the molecular mechanisms underlying male infertility. The selection of relevant targets based on a single analysis is not always feasible, due to the growing number of prot
Externí odkaz:
https://doaj.org/article/542369241814420fa72006a3842156dc
Autor:
Bárbara Matos, Antoniel A. S. Gomes, Raquel Bernardino, Marco G. Alves, John Howl, Carmen Jerónimo, Margarida Fardilha
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1199 (2024)
Protein phosphatase 1 (PP1) complexes have emerged as promising targets for anticancer therapies. The ability of peptides to mimic PP1-docking motifs, and so modulate interactions with regulatory factors, has enabled the creation of highly selective
Externí odkaz:
https://doaj.org/article/04fa73ddba314e2797df7cff7b2f59bb
Autor:
Luigi Fausto Canonico, Claudia De Clemente, Margarida Fardilha, Ana Filipa Ferreira, Maria Isabella Maremonti, David Dannhauser, Filippo Causa, Paolo Antonio Netti
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Mammalian sperm motility is getting more relevant due to rising infertility rates worldwide, generating the need to improve conventional analysis and diagnostic approaches. Nowadays, computer assisted sperm analysis (CASA) technologies represent a po
Externí odkaz:
https://doaj.org/article/70bd7a01c00d45f5bc9d948203c29c98
Autor:
Anna Kobrock, Bárbara Matos, Daniela Patrício, Liliana Grenho, John Howl, Margarida Fardilha, Pedro S. Gomes
Publikováno v:
Cells, Vol 13, Iss 13, p 1143 (2024)
The reparative and regenerative capabilities of dental pulp stem cells (DPSCs) are crucial for responding to pulp injuries, with protein phosphatase 1 (PP1) playing a significant role in regulating cellular functions pertinent to tissue healing. Acco
Externí odkaz:
https://doaj.org/article/5b6eb8779dbf4083b6360366d0583c0c
Autor:
Joana Quelhas, Patrícia Pinto-Pinho, Graça Lopes, António Rocha, Rosário Pinto-Leite, Margarida Fardilha, Bruno Colaço
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
The sex of the animals is of paramount importance in many animal production systems. This is particularly evident in the production of milk or in breeding programs focused on the production of female animals. In some cases, slaughter or euthanasia of
Externí odkaz:
https://doaj.org/article/2bf7c3e8558a43f9b1226ed4694a789f
Autor:
Tânia Lima, Catarina Macedo-Silva, Diana Felizardo, João Fraga, Isa Carneiro, Carmen Jerónimo, Rui Henrique, Margarida Fardilha, Rui Vitorino
Publikováno v:
Current Oncology, Vol 30, Iss 3, Pp 2729-2742 (2023)
Gal-3 plays an important role in cell survival, mRNA splicing, and cell–cell and cell–matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promisi
Externí odkaz:
https://doaj.org/article/46e39dbe6aa24a499db3c00905c2b4ea
Autor:
Vânia Carlos, Mário Rodrigues, Bárbara Matos, Lurdes Gonçalves, Fernando Ribeiro, Margarida Fardilha
Publikováno v:
Frontiers in Education, Vol 8 (2023)
We are in an era where keeping students focused and interested can be challenging. Furthermore, it is relevant, in avoiding students dropping out and increasing students’ achievements, to research how student engagement can be nurtured and how this
Externí odkaz:
https://doaj.org/article/3fa6476d77cf404d8248def4d81d558b
Autor:
Patrícia Pinto-Pinho, João Soares, Pedro Esteves, Rosário Pinto-Leite, Margarida Fardilha, Bruno Colaço
Publikováno v:
Animals, Vol 14, Iss 2, p 217 (2024)
Studying proteins associated with sex chromosomes can provide insights into sex-specific proteins. Membrane proteins accessible through the cell surface may serve as excellent targets for diagnostic, therapeutic, or even technological purposes, such
Externí odkaz:
https://doaj.org/article/392ddbd361d645e6ac8874d28ca1557b
Autor:
Catarina Jota-Baptista, Ana I. Faustino-Rocha, Margarida Fardilha, Rita Ferreira, Paula A. Oliveira, Marta Regueiro-Purriños, José A. Rodriguez-Altonaga, José M. Gonzalo-Orden, Mário Ginja
Publikováno v:
Veterinary World, Vol 15, Iss 3, Pp 627-633 (2022)
Background and Aim: Male hypogonadism results from failure to produce physiological levels of testosterone. Testosterone in men is essential in masculine development, sperm production, and adult man's health. Osteoporosis is one of the consequences o
Externí odkaz:
https://doaj.org/article/7a6c72c930fe46e995d8fe64d392761a