Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Margarida F. B. SILVA"'
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Akademický článek
Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation
Autor: Marta B. Fernandes, Márcia Costa, Maria Filipe Ribeiro, Sónia Siquenique, Sónia Sá Santos, Joana Martins, Ana V. Coelho, Margarida F. B. Silva, Cecília M. P. Rodrigues, Susana Solá
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Recent evidence suggests that neural stem cell (NSC) fate is highly dependent on mitochondrial bioenergetics. Tauroursodeoxycholic acid (TUDCA), an endogenous neuroprotective bile acid and a metabolic regulator, stimulates NSC proliferation and enhan
Externí odkaz: https://doaj.org/article/1bc7b19a0cc04d5a8ad1c1431c99501c
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2
Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation
Autor: Maria Filipe Ribeiro, Marta B. Fernandes, Ana Varela Coelho, Sónia Siquenique, Cecília M. P. Rodrigues, Joana Martins, Sónia Sá Santos, Margarida F. B. Silva, Susana Solá, Márcia Costa
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
Recent evidence suggests that neural stem cell (NSC) fate is highly dependent on mitochondrial bioenergetics. Tauroursodeoxycholic acid (TUDCA), an endogenous neuroprotective bile acid and a metabolic regulator, stimulates NSC proliferation and enhan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d650eb681314a50e8c4b07cdf7593b74
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4
Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS
Autor: M.A. Farelo, Ruurdtje Hoekstra, Robert A. F. M. Chamuleau, Ronald J. A. Wanders, Margarida F. B. Silva, Aziza A. A. Adam, Marco F. Moedas, Lodewijk IJlst
Publikováno v: Analytical biochemistry, 535, 47-55. Academic Press Inc.
Current methodologies for the assessment of urea cycle (UC) enzymatic activity are insufficient to accurately evaluate this pathway in biological specimens where lower UC is expected. Liver cell lines, including HepaRG, have been described to have li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211ae5a0efcd38015becaf21df3858f3
https://pubmed.ncbi.nlm.nih.gov/28757091
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Retrospective study of the medium-chain acyl-CoA dehydrogenase deficiency in Portugal
Autor: Paula Leandro, Elisa Leão-Teles, Ana Maria Minarelli Gaspar, Laura Vilarinho, A. Lopes, Esmeralda Martins, A. Luz, FV Ventura, Isabel Rivera, Ruben Ramos, Helena Fonseca, Margarida F. B. Silva, I. Tavares de Almeida, Luísa Diogo, H. Rocha
Publikováno v: Clinical Genetics. 85:555-561
Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is the commonest genetic defect of mitochondrial fatty acid β-oxidation. About 60% of MCADD patients are homozygous for the c.985A>G (p.Lys329Glu) mutation in the ACADM gene (G985 allele). Herei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41f7ee134041b981945e57f006da1737
https://doi.org/10.1111/cge.12227
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Transient decrease of hepatic NAD+ and amino acid alterations during treatment with valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics
Autor: Margarida F. B. Silva, Lodewijk IJlst, Isabel Tavares de Almeida, Ronald J. A. Wanders, Arno van Cruchten, Luísa Diogo, Marco F. Moedas, Wim Kulik
Publikováno v: Metabolomics, 12(8). Springer New York
Background Therapeutic administration of the drug valproate (VPA) results in metabolic changes at the hepatic level that have not been fully characterized. Interference of this branched-chain fatty acid with the oxidative metabolism of amino acids ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d875520a256f625215e4b31795c98f02
https://doi.org/10.1007/s11306-016-1091-9
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Valproic acid utilizes the isoleucine breakdown pathway for its complete β-oxidation
Autor: Luísa Diogo, Lodewijk IJlst, Jos P.N. Ruiter, Margarida F. B. Silva, Paula Garcia, Rob Ofman, Isabel Tavares de Almeida, Marinus Duran, Marco Moedas, Ronald J.A. Wanders, Paula B.M. Luís
Publikováno v: Biochemical pharmacology, 82(11), 1740-1746. Elsevier Inc.
Valproic acid (VPA) is a simple branched medium-chain fatty acid with expanding therapeutic applications beyond its prime anticonvulsant properties. Aims (1) To resolve the underlying basis for the interference of valproate with the isoleucine degrad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4808cc3f04f8daf2c8fc19e459266e0a
https://doi.org/10.1016/j.bcp.2011.07.103
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Mathematics in chemistry: indeterminate forms and their meaning
Autor: Rita Castro, Margarida F. B. Silva, Manuel A. P. Segurado
Publikováno v: International Journal of Mathematical Education in Science and Technology. 42:664-679
The mathematical language and its tools are complementary to the formalism in chemistry, in particular at an advanced level. It is thus crucial, for its understanding, that students acquire a solid knowledge in Calculus and that they know how to appl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee0a1bf3a6286ceac216a6d8a20a8e83
https://doi.org/10.1080/0020739x.2010.550945
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9
Drug-induced effects on urea cycle enzymes associate with altered ammonia metabolism, NAD + biosynthesis and mitochondrial protein acetylome
Autor: Ronald Ja Wanders, Marco F. Moedas, Mafalda Farelo, Lodewijk IJlst, Margarida F. B. Silva, Antonina Pereira, João M. Caio
Publikováno v: Free Radical Biology and Medicine. 120:S108
Nitrogen metabolism in humans, as ureotelic organisms, involves reciprocal implications on mitochondrial function and redox homeostasis. The clinical use of valproic acid (VPA), a lysine deacetylase inhibitor, is potentially associated with undesired
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f815929bb8d39b02b92e919427bd16b
https://doi.org/10.1016/j.freeradbiomed.2018.04.357
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Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis
Autor: Carina Prip-Buus, Isabel Tavares de Almeida, Lodewijk IJlst, Margarida F. B. Silva, C. C. P. Aires, Marinus Duran, Femke S. Stet, Ronald J.A. Wanders
Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2010, 79 (5), pp.792-799. ⟨10.1016/j.bcp.2009.10.011⟩
Biochemical pharmacology, 79(5), 792-799. Elsevier Inc.
Background/Aims: Carnitine Palmitoyl-transferase I (CPT I) catalyses the synthesis of long-chain (LC)-acylcarnitines from LC-acyl-CoA esters. It is the rate-limiting enzyme of mitochondrial fatty acid, beta-oxidation (FAO) pathway and its activity is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b11a427753f1ae8127c34e744833f1e
https://doi.org/10.1016/j.bcp.2009.10.011
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