Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Margarida Espadinha"'
Autor:
Margarida Espadinha, Valentina Barcherini, Lídia M. Gonçalves, Elies Molins, Alexandra M. M. Antunes, Maria M. M. Santos
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 208 (2021)
Gastric cancer is one of the deadliest cancers in modern societies, so there is a high level of interest in discovering new drugs for this malignancy. Previously, we demonstrated the ability of tryptophanol-derived polycyclic compounds to activate th
Externí odkaz:
https://doaj.org/article/412a8561a1b14676b6b04afa9ff93646
Autor:
Elizabeth A. Lopes, Margarida Espadinha, Joana D. Amaral, Rebecca Piccarducci, Elisa Zappelli, Simona Daniele, Claudia Martini, Mattia Mori, Cecília M. P. Rodrigues, Daniel J. V. A. dos Santos, Maria M. M. Santos
Publikováno v:
4th International Symposium of Young Researchers on Medicinal Plants and Natural Product Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18106a81ca643447b5c58cd90981b209
https://doi.org/10.14232/syrmpnpr.2023.12
https://doi.org/10.14232/syrmpnpr.2023.12
Autor:
Margarida Espadinha, Elizabeth A. Lopes, Vanda Marques, Joana D. Amaral, Daniel J.V.A. dos Santos, Mattia Mori, Simona Daniele, Rebecca Piccarducci, Elisa Zappelli, Claudia Martini, Cecília M.P. Rodrigues, Maria M.M. Santos
Publikováno v:
European Journal of Medicinal Chemistry. 241:114637
MDM2 and MDM4 are key negative regulators of p53, an important protein involved in several cell processes (e.g. cell cycle and apoptosis). Not surprisingly, the p53 tumor suppressor function is inactivated in tumors overexpressing these two proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527e3594a592ff9acbe9f3919118c704
https://doi.org/10.1016/j.ejmech.2022.114637
https://doi.org/10.1016/j.ejmech.2022.114637
Autor:
Lídia Gonçalves, Margarida Espadinha, Valentina Barcherini, Elies Molins, Alexandra M. M. Antunes, Maria M. M. Santos
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pharmaceuticals
Volume 14
Issue 3
Pharmaceuticals, Vol 14, Iss 208, p 208 (2021)
instname
Pharmaceuticals
Volume 14
Issue 3
Pharmaceuticals, Vol 14, Iss 208, p 208 (2021)
Gastric cancer is one of the deadliest cancers in modern societies, so there is a high level of interest in discovering new drugs for this malignancy. Previously, we demonstrated the ability of tryptophanol-derived polycyclic compounds to activate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2973922869b9565862e49adb31f07576
http://hdl.handle.net/10261/239456
http://hdl.handle.net/10261/239456
Protein-protein interactions (PPIs) are essential in the regulation of many biological pathways including apoptosis and cell cycle arrest. When the balance of PPIs is altered pathologies can appear. In this chapter the authors give an overview of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14be0f9d53b7c666f44001575b369040
https://doi.org/10.1016/b978-0-12-818349-6.00010-8
https://doi.org/10.1016/b978-0-12-818349-6.00010-8
Autor:
Lucía Viejo, María Isabel Rodríguez-Franco, Elies Molins, Daniel J. V. A. dos Santos, Lídia Gonçalves, Maria M. M. Santos, Clara Herrera-Arozamena, Cristóbal de los Ríos, Margarida Espadinha, Ricardo M R M Lopes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
N-Methyl-D-aspartate receptors (NMDARs) are crucial for the normal function of the central nervous system (CNS), and fundamental in memory and learning-related processes. The overactivation of these receptors is associated with numerous neurodegenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a397ed2a33305f849048690268adb758
http://hdl.handle.net/10261/219127
http://hdl.handle.net/10261/219127
Autor:
Michelle R. Arkin, Andrea Basso, Pietro Capurro, Stuart J. Conway, Margarida Espadinha, M. Isabel García-Moreno, José M. García Fernández, Kamal Kumar, Elena Lenci, Qingliang Li, José L. Medina-Franco, Carmen Ortiz Mellet, Amy Trinh Pham, Praveen P.N. Rao, Fernanda I. Saldívar-González, Elena M. Sánchez-Fernández, Maria M.M. Santos, Arash Shakeri, Andrea Trabocchi, Chris G.M. Wilson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9149200d8af86edc3aef38b538ac6a89
https://doi.org/10.1016/b978-0-12-818349-6.01002-5
https://doi.org/10.1016/b978-0-12-818349-6.01002-5
Autor:
Maria M. M. Santos, Margarida Espadinha, Lucília Saraiva, Marco G. Alves, Liliana Raimundo, Joana B. Loureiro, Joana Soares
Publikováno v:
British Journal of Pharmacology. 175:3947-3962
BACKGROUND AND PURPOSE Impairment of the tumour suppressor p53 pathway is a major event in human cancers, making p53 activation one of the most attractive therapeutic strategies to halt cancer. Here, we have identified a new selective p53 activator a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cbef5371df82e7af4b3ce5dffcce697
https://doi.org/10.1111/bph.14468
https://doi.org/10.1111/bph.14468
Publikováno v:
ChemMedChem. 13:2053-2056
A more sustainable process for the synthesis of the long-acting muscarinic acetylcholine antagonist umeclidinium bromide is described. Specifically, we report the synthesis of ethyl 1-(2-chloroethyl)-4-piperidinecarboxylate, a key intermediate in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e84e35decbd9ce5701fc47df84bad0
https://doi.org/10.1002/cmdc.201800387
https://doi.org/10.1002/cmdc.201800387
Autor:
Sara Gomes, Joana Soares, Alexandra M. M. Antunes, Maria M. M. Santos, Lucília Saraiva, Flávio Reis, Liliana Raimundo, Valentina Barcherini, Célia Gomes, Margarida Espadinha
Publikováno v:
Proceedings of 5th International Electronic Conference on Medicinal Chemistry.
The tumour suppressor p53 is a pivotal target in cancer therapy as this protein is inactive in all human cancers. In the last years, our research group has been working on the design and synthesis of novel small molecules that are able to reactivate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75faf86637da4e0f95aed46813d07cb7
https://doi.org/10.3390/ecmc2019-06403
https://doi.org/10.3390/ecmc2019-06403