Zobrazeno 1 - 10
of 416
pro vyhledávání: '"Margarida Duarte"'
Autor:
Helena Castro, Maria Inês Rocha, Margarida Duarte, Jordi Vilurbina, Ana Georgina Gomes-Alves, Teresa Leao, Filipa Dias, Bruce Morgan, Marcel Deponte, Ana Maria Tomás
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103122- (2024)
Typical two-cysteine peroxiredoxins (2-Cys-PRXs) are H2O2-metabolizing enzymes whose activity relies on two cysteine residues. Protists of the family Trypanosomatidae invariably express one cytosolic 2-Cys-PRX (cPRX1). However, the Leishmaniinae sub-
Externí odkaz:
https://doaj.org/article/4811e09fbbfc4475a405562ce909be47
Autor:
Isabel Paulos Mesquita, Margarida Duarte, Eduardo Espada, Daniela Alves, Joao Forjaz de Lacerda, João Raposo
Publikováno v:
HemaSphere, Vol 7, p e550406a (2023)
Externí odkaz:
https://doaj.org/article/b6ef399cb9dd4a59bfee04cdb3489f50
Autor:
Sofia Reis Brandão, Ana Reis-Mendes, Margarida Duarte-Araújo, Maria João Neuparth, Hugo Rocha, Félix Carvalho, Rita Ferreira, Vera Marisa Costa
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 921 (2023)
Doxorubicin (DOX) and mitoxantrone (MTX) are classical chemotherapeutic agents used in cancer that induce similar clinical cardiotoxic effects, although it is not clear if they share similar underlying molecular mechanisms. We aimed to assess the eff
Externí odkaz:
https://doaj.org/article/665350ccb6244dc68ae15ac3f6f35d1e
Autor:
Sofia Reis Brandão, Ana Reis-Mendes, Margarida Duarte-Araújo, Maria João Neuparth, Félix Carvalho, Rita Ferreira, Vera Marisa Costa
Publikováno v:
RevSALUS, Vol 4, Iss Sup (2022)
Externí odkaz:
https://doaj.org/article/f2ae038b3b414331a37e4498f3176d42
Publikováno v:
Heliyon, Vol 8, Iss 2, Pp e08907- (2022)
The COVID-19 pandemic has spread throughout the globe affecting countries worldwide. However, several differences have been observed in the number of daily new cases, the COVID-19 reproduction rate, and the severity of the disease in different countr
Externí odkaz:
https://doaj.org/article/e546db1336b54513aeb7b75a444fb4c6
Autor:
Marisa Esteves-Monteiro, Daniela Menezes-Pinto, Mariana Ferreira-Duarte, Patrícia Dias-Pereira, Manuela Morato, Margarida Duarte-Araújo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13233 (2022)
Diabetes mellitus (DM) is a chronic progressive metabolic disorder associated with several gastrointestinal complications, affecting up to 75% of patients. Knowing that Angiotensin II (AngII) also regulates intestinal contraction, we decided to evalu
Externí odkaz:
https://doaj.org/article/5dfad9e35b5a41528bd0ea8ca0e67a1b
Autor:
Sandra Specht, Linda Liedgens, Margarida Duarte, Alexandra Stiegler, Ulrike Wirth, Maike Eberhardt, Ana Tomás, Kai Hell, Marcel Deponte
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 363-374 (2018)
Mia40/CHCHD4 and Erv1/ALR are essential for oxidative protein folding in the mitochondrial intermembrane space of yeast and mammals. In contrast, many protists, including important apicomplexan and kinetoplastid parasites, lack Mia40. Furthermore, th
Externí odkaz:
https://doaj.org/article/bfee3356b52e479a9eacd274f163f22d
Autor:
Ana Reis-Mendes, Ana Isabel Padrão, José Alberto Duarte, Salomé Gonçalves-Monteiro, Margarida Duarte-Araújo, Fernando Remião, Félix Carvalho, Emília Sousa, Maria Lourdes Bastos, Vera Marisa Costa
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1725 (2021)
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several types of cancer. Despite its efficacy, DOX can potentially cause fatal adverse effects, like cardiotoxicity. This work aimed to assess the role of inflammatio
Externí odkaz:
https://doaj.org/article/ec9e2f7caa8e4a5d832370426ace8b2f
Autor:
Mariana Ferreira-Duarte, Tiago Rodrigues-Pinto, Teresa Sousa, Miguel A. Faria, Maria Sofia Rocha, Daniela Menezes-Pinto, Marisa Esteves-Monteiro, Fernando Magro, Patrícia Dias-Pereira, Margarida Duarte-Araújo, Manuela Morato
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4836 (2021)
Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle but also indirectly, interfering with myenteric neuromodulation mediated by the activation of AT1 /AT2 receptors. In this article, we aimed to explore whic
Externí odkaz:
https://doaj.org/article/d539f98f70974ee9803df70713e5ddba
Autor:
Ana Reis-Mendes, José Luís Dores-Sousa, Ana Isabel Padrão, Margarida Duarte-Araújo, José Alberto Duarte, Vítor Seabra, Salomé Gonçalves-Monteiro, Fernando Remião, Félix Carvalho, Emília Sousa, Maria Lourdes Bastos, Vera Marisa Costa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 510 (2021)
Mitoxantrone (MTX) is a pharmaceutical drug used in the treatment of several cancers and refractory multiple sclerosis (MS). Despite its therapeutic value, adverse effects may be severe, namely the frequently reported cardiotoxicity, whose mechanisms
Externí odkaz:
https://doaj.org/article/dcd80e51595a4a5ba63be05dcd0c6c2c