Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Margarida C. Quaresma"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2688 (2022)
The multi-organ disease cystic fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, a cAMP regulated chloride (Cl−) and bicarbonate (HCO3−) ion channel expressed at the apical plasma
Externí odkaz:
https://doaj.org/article/fabce5bbafac46caa456966558e4e50f
Autor:
Madalena C. Pinto, Margarida C. Quaresma, Iris A. L. Silva, Violeta Railean, Sofia S. Ramalho, Margarida D. Amaral
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13064 (2021)
SLC26A9, a constitutively active Cl− transporter, has gained interest over the past years as a relevant disease modifier in several respiratory disorders including Cystic Fibrosis (CF), asthma, and non-CF bronchiectasis. SLC26A9 contributes to epit
Externí odkaz:
https://doaj.org/article/55e88220886644fe92a11dfac5543cf3
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3133 (2020)
One of the key features associated with the substantial increase in life expectancy for individuals with CF is an elevated predisposition to cancer, firmly established by recent studies involving large cohorts. With the recent advances in cystic fibr
Externí odkaz:
https://doaj.org/article/a9a7c7353da44332afa414ce348fcb19
Autor:
Margarida C Quaresma, Hugo M Botelho, Ines Pankonien, Cláudia S Rodrigues, Madalena C Pinto, Pau R Costa, Aires Duarte, Margarida D Amaral
Publikováno v:
Life science alliance. 5(9)
Mutations in the CFTR anion channel cause cystic fibrosis (CF) and have also been related to higher cancer incidence. Previously we proposed that this is linked to an emerging role of functional CFTR in protecting against epithelial–mesenchymal tra
Autor:
Luís S Sousa, Violeta Railean, Margarida C. Quaresma, Ines Pankonien, Jonas Fuxe, Tereza Doušová, Luka A. Clarke, Margarida D. Amaral, Iris A.L. Silva
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 10, Pp 1-18 (2020)
Cell Death and Disease, Vol 11, Iss 10, Pp 1-18 (2020)
Cystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent evidence indicates that CFTR plays a role in other cellular processes, nam
Autor:
Ines Pankonien, Filipa B. Simões, Iris A.L. Silva, Violeta Railean, Margarida C. Quaresma, Luka A. Clarke, Arthur Kmit, Margarida D. Amaral
Publikováno v:
Life Science Alliance
Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
Airway mucus obstruction is the main cause of morbidity in
Airway mucus obstruction is the main cause of morbidity in