Výsledky vyhledávání - "Margarida C Gomes"

Akademický článek

The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection.

Autor: Margarida C Gomes, Yara Tasrini, Sujatha Subramoni, Kirsty Agnoli, Joana R Feliciano, Leo Eberl, Pamela Sokol, David O'Callaghan, Annette C Vergunst

Publikováno v: PLoS Pathogens, Vol 14, Iss 12, p e1007473 (2018)

The opportunistic pathogen Burkholderia cenocepacia is particularly life-threatening for cystic fibrosis (CF) patients. Chronic lung infections with these bacteria can rapidly develop into fatal pulmonary necrosis and septicaemia. We have recently sh

Externí odkaz: https://doaj.org/article/26623474433a49e3be3ee968701cd00a

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Akademický článek

Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation.

Autor: Jennifer Mesureur, Joana R Feliciano, Nelly Wagner, Margarida C Gomes, Lili Zhang, Monica Blanco-Gonzalez, Michiel van der Vaart, David O'Callaghan, Annemarie H Meijer, Annette C Vergunst

Publikováno v: PLoS Pathogens, Vol 13, Iss 6, p e1006437 (2017)

Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute in

Externí odkaz: https://doaj.org/article/d2b2b869bab5405b897f44d4d279380e

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Shigellainduces epigenetic reprogramming of zebrafish neutrophils

Autor: Margarida C. Gomes, Dominik Brokatzky, Magdalena K. Bielecka, Fiona C. Wardle, Serge Mostowy

SUMMARYTrained immunity is a long-term memory of innate immune cells, generating an improved response upon re-infection.Shigellais an important human pathogen and inflammatory paradigm for which there is no effective vaccine. Using zebrafish larvae w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6feb805987bf5ab1af7d58deaffdef2
https://doi.org/10.1101/2022.11.03.515069

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Meeting report: Zebrafish Infection and Immunity 2019

Autor: Milka Sarris, Vincenzo Torraca, Serge Mostowy, Margarida C. Gomes

Publikováno v: Lab Animal. 48:284-287

Experts in the field met at the London School of Hygiene & Tropical Medicine (UK) to discuss the role of zebrafish in advancing fundamental research and discovering therapeutic innovations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1116c16d34f357004b91c6c89328da56
https://doi.org/10.1038/s41684-019-0400-0

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A membrane-depolarizing toxin substrate of the

Autor: Fatima R, Ulhuq, Margarida C, Gomes, Gina M, Duggan, Manman, Guo, Chriselle, Mendonca, Grant, Buchanan, James D, Chalmers, Zhenping, Cao, Holger, Kneuper, Sarah, Murdoch, Sarah, Thomson, Henrik, Strahl, Matthias, Trost, Serge, Mostowy, Tracy, Palmer

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Staphylococcus aureus, a human commensal organism that asymptomatically colonizes the nares, is capable of causing serious disease following breach of the mucosal barrier. S. aureus strains encode a type VII secretion system that is requ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ab49dc5ecb3e6db9ebe35af39f41ac0
https://pubmed.ncbi.nlm.nih.gov/32769205

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