Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Margaretha Van Der Mey"'
Autor:
Hildegard Boss, Kirsten M. Bommele, Armin Hatzelmann, Geert Jan Sterk, Margaretha Van Der Mey, Hendrik Timmerman, Mike Van Slingerland
Publikováno v:
Journal of Medicinal Chemistry. 46:2008-2016
In this study, the synthesis and in vitro and in vivo pharmacological investigations of a new series of phthalazinone/pyridazinone hybrids with both PDE3 and PDE4 inhibitory activities are described. These compounds combine the pharmacophores of rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d046689594c30558075b30088f2ea1
https://doi.org/10.1021/jm030776l
https://doi.org/10.1021/jm030776l
Autor:
Hildegard Boss, Ivonne J. Van Der Laan, Hendrik Timmerman, Geert Jan Sterk, Armin Hatzelmann, Margaretha Van Der Mey
Publikováno v:
Journal of Medicinal Chemistry. 45:2520-2525
The synthesis and biological activities of a series of N-substituted cis-4a,5,6,7,8,8a-hexa- and cis-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones are described. It was found that compounds bearing a cycloalkyl group at the 2-position exhibit the highest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69133d0f7480c4abc1c8d2ca2003cf1
https://doi.org/10.1021/jm0110340
https://doi.org/10.1021/jm0110340
Autor:
Ulrich Thibaut, Ivonne Johanna Van Der Laan, Wolf R. Ulrich, Hendrik Timmerman, Geert Jan Sterk, Gerard P. M. van Klink, Margaretha Van Der Mey, Hatzelmann Armin
Publikováno v:
Journal of Medicinal Chemistry. 44:2523-2535
A series of 4-aryl-substituted cis-4a,5,8,8a-tetra- and cis-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-ones with high inhibitory activity toward cAMP-specific phosphodiesterase (PDE4) was synthesized. To study structure-activity relationships various su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59600e18ec57bf411c71a3dd99b9c970
https://doi.org/10.1021/jm010838c
https://doi.org/10.1021/jm010838c
Autor:
Wolf R. Ulrich, Armin Hatzelmann, Ivonne Johanna Van Der Laan, Ulrich Thibaut, Hendrik Timmerman, Gerard P. M. van Klink, Geert Jan Sterk, Margaretha Van der Mey
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b205d2213fb3ba610f3804bba2b8d4
https://doi.org/10.1002/chin.200145165
https://doi.org/10.1002/chin.200145165
Autor:
Ulrich Thibaut, Ivonne Johanna Van Der Laan, Hendrik Timmerman, Geert Jan Sterk, Margaretha Van der Mey, Armin Hatzelmann
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70de7873c9578e61f6fe1ed768e1e6e1
https://doi.org/10.1002/chin.200145164
https://doi.org/10.1002/chin.200145164
Autor:
Hendrik Timmerman, Hildegard Boss, Margaretha Van der Mey, Geert Jan Sterk, Kees Goubitz, Armin Hatzelmann, Henk Schenk, Dennis Couwenberg
Publikováno v:
Journal of Medicinal Chemistry, 45, 2526-33. American Chemical Society
der Van Mey, M, Boss, H, Couwenberg, D, Hatzelmann, A, Sterk, G J, Goubitz, K, Schenk, H & Timmerman, H 2002, ' Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra-and cis-hexahydrophthalazinones ', Journal of Medicinal Chemistry, vol. 45, pp. 2526-33 . https://doi.org/10.1021/jm0110338
Journal of Medicinal Chemistry, 45, 2526-2533. American Chemical Society
der Van Mey, M, Boss, H, Couwenberg, D, Hatzelmann, A, Sterk, G J, Goubitz, K, Schenk, H & Timmerman, H 2002, ' Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra-and cis-hexahydrophthalazinones ', Journal of Medicinal Chemistry, vol. 45, pp. 2526-33 . https://doi.org/10.1021/jm0110338
Journal of Medicinal Chemistry, 45, 2526-2533. American Chemical Society
Recently, we reported that 4-catechol-substituted cis-(+/-)-4a,5,6,7,8,8a-hexa- and cis-(+/-)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones show potent inhibition of phosphodiesterase (PDE4) activity, while the corresponding trans racemic mixtures exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8ea68cc0940f988663a1ef1f6e0417
https://research.vu.nl/en/publications/2fdf851e-0f3d-4310-8869-80246845a738
https://research.vu.nl/en/publications/2fdf851e-0f3d-4310-8869-80246845a738
