Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Margarete Mehrabian"'
Autor:
Iina Tuominen, Brie K. Fuqua, Calvin Pan, Nicole Renaud, Kevin Wroblewski, Mete Civelek, Kara Clerkin, Ashot Asaryan, Sara G. Haroutunian, Joseph Loureiro, Jason Borawski, Guglielmo Roma, Judith Knehr, Walter Carbone, Samuel French, Brian W. Parks, Simon T. Hui, Margarete Mehrabian, Clara Magyar, Rita M. Cantor, Chinweike Ukomadu, Aldons J. Lusis, Simon W. Beaven
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 199-220 (2021)
Background & Aims: Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury. Our aim was to characterize the genetic architecture of carbon tetrachloride (CCl4)-induced liver fibrosis using the Hybrid Mouse Diversity
Externí odkaz:
https://doaj.org/article/805a57b68c664391ba2c3054c6d2c50d
Autor:
Rebecca C Schugar, Christy M Gliniak, Lucas J Osborn, William Massey, Naseer Sangwan, Anthony Horak, Rakhee Banerjee, Danny Orabi, Robert N Helsley, Amanda L Brown, Amy Burrows, Chelsea Finney, Kevin K Fung, Frederick M Allen, Daniel Ferguson, Anthony D Gromovsky, Chase Neumann, Kendall Cook, Amy McMillan, Jennifer A Buffa, James T Anderson, Margarete Mehrabian, Maryam Goudarzi, Belinda Willard, Tytus D Mak, Andrew R Armstrong, Garth Swanson, Ali Keshavarzian, Jose Carlos Garcia-Garcia, Zeneng Wang, Aldons J Lusis, Stanley L Hazen, Jonathan Mark Brown
Publikováno v:
eLife, Vol 11 (2022)
Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide
Externí odkaz:
https://doaj.org/article/1bf775b855894d52aa435ffcd48a01d8
Autor:
Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon T Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons J Lusis, Xia Yang
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. This chronic liver disease has a poorly understood etiolo
Externí odkaz:
https://doaj.org/article/6774b51542b843a1b8717f6629c5094f
Autor:
Frode Norheim, Karthickeyan Chella Krishnan, Thomas Bjellaas, Laurent Vergnes, Calvin Pan, Brian W Parks, Yonghong Meng, Jennifer Lang, James A Ward, Karen Reue, Margarete Mehrabian, Thomas E Gundersen, Miklós Péterfy, Knut T Dalen, Christian A Drevon, Simon T Hui, Aldons J Lusis, Marcus M Seldin
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 1, Pp n/a-n/a (2021)
Abstract To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic data from a cohort of about 100 diverse inbred strains of mice fed a high‐fat/high
Externí odkaz:
https://doaj.org/article/79a471c7fc2a4e9faa35faa4f6221234
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Responses to a high fat, high sucrose (HFHS) diet vary greatly among inbred strains of mice. We sought to examine the epigenetic (DNA methylation) changes underlying these differences as well as variation in weight loss when switched to a low-fat cho
Externí odkaz:
https://doaj.org/article/1ca34234f4ad40078fa0c9639d546b7e
Autor:
Frode Norheim, Thomas Bjellaas, Simon T. Hui, Karthickeyan Chella Krishnan, Jakleen Lee, Sonul Gupta, Calvin Pan, Yehudit Hasin-Brumshtein, Brian W. Parks, Daniel Y. Li, Hai H. Bui, Marian Mosier, Yuping Wu, Adriana Huertas-Vazquez, Stanley L. Hazen, Thomas E. Gundersen, Margarete Mehrabian, W.H.Wilson Tang, Andrea L. Hevener, Christian A. Drevon, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1164-1174 (2018)
Elevated hepatic ceramide levels have been implicated in both insulin resistance (IR) and hepatic steatosis. To understand the factors contributing to hepatic ceramide levels in mice of both sexes, we have quantitated ceramides in a reference populat
Externí odkaz:
https://doaj.org/article/f06455053a49487895841ef47b289931
Autor:
Elin Org, Yuna Blum, Silva Kasela, Margarete Mehrabian, Johanna Kuusisto, Antti J. Kangas, Pasi Soininen, Zeneng Wang, Mika Ala-Korpela, Stanley L. Hazen, Markku Laakso, Aldons J. Lusis
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish men from the Metab
Externí odkaz:
https://doaj.org/article/fc80a642076f4a0f80f792cfd6e0c82c
Autor:
Frode Norheim, Simon T. Hui, Emre Kulahcioglu, Margarete Mehrabian, Rita M. Cantor, Calvin Pan, Brian W. Parks, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 178-187 (2017)
The etiology of nonalcoholic fatty liver disease is complex and influenced by factors such as obesity, insulin resistance, hyperlipidemia, and sex. We now report a study on sex difference in hepatic steatosis in the context of genetic variation using
Externí odkaz:
https://doaj.org/article/3ab0bb806a874591a0b827ec024d84c7
Autor:
Aldons J. Lusis, Marcus M. Seldin, Hooman Allayee, Brian J. Bennett, Mete Civelek, Richard C. Davis, Eleazar Eskin, Charles R. Farber, Simon Hui, Margarete Mehrabian, Frode Norheim, Calvin Pan, Brian Parks, Christoph D. Rau, Desmond J. Smith, Thomas Vallim, Yibin Wang, Jessica Wang
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 925-942 (2016)
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mappi
Externí odkaz:
https://doaj.org/article/2b1437dd97184028a39a17b825fbb20f
Autor:
Margarete Mehrabian, Lawrence W. Castellani, Ping-Zi Wen, Jack Wong, Tat Rithaporn, Susan Y. Hama, Gregory P. Hough, David Johnson, John J. Albers, Giuliano A. Mottino, Joy S. Frank, Mohamad Navab, Alan M. Fogelman, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 12, Pp 1936-1946 (2000)
Strain CAST/Ei (CAST) mice exhibit unusually low levels of high density lipoproteins (HDL) as compared with most other strains of mice, including C57BL/6J (B6). This appears to be due in part to a functional deficiency of lecithin:cholesterol acyltra
Externí odkaz:
https://doaj.org/article/306b4bc1b7fa4004951a999f20acaf6f