Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Margareta Bielenstein"'
Publikováno v:
Analytica Chimica Acta. 492:253-260
Analysis of urine samples from a clinical study of ropivacaine and its metabolites, 3-hydroxyropivacaine (3-OH-ropivacaine) and PPX, by an LC–UV method showed high concentrations of 3-hydroxyropivacaine, 2–50 times higher than expected. In the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88e86cf86c1979f4f7f8584a82e6c42c
https://doi.org/10.1016/s0003-2670(03)00574-9
https://doi.org/10.1016/s0003-2670(03)00574-9
Autor:
Yvonne Askemark, Niklas Tyrefors, Mohamed Abdel-Rehim, Torbjörn Arvidsson, Margareta Bielenstein
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 741:175-188
A sensitive, selective and accurate high-performance liquid chromatographic-tandem mass spectrometric assay was developed and validated for the determination of lidocaine and its metabolites 2,6-dimethylaniline (2,6-xylidine), monoethylglycinexylidid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13bc5d4d4bafa2eae11372b70f0d29f
https://doi.org/10.1016/s0378-4347(00)00054-2
https://doi.org/10.1016/s0378-4347(00)00054-2
Publikováno v:
Scopus-Elsevier
Solid-phase microextraction in combination with capillary gas chromatography and a nitrogen–phosphorus detector as a bioanalysis tool was investigated. Lidocaine and three of its metabolites were used as model compounds, and human plasma and urine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dd8ed8c9ca23cb0a2eee25b24ac7f3
https://doi.org/10.1002/(sici)1520-667x(2000)12:5<308::aid-mcs5>3.0.co
https://doi.org/10.1002/(sici)1520-667x(2000)12:5<308::aid-mcs5>3.0.co
Autor:
B Bjorkstrand, Mats O. Karlsson, Mohamed Abdel-Rehim, Per Ljungman, Margareta Bielenstein, M Johansson, Ulrika S H Svensson, Moustapha Hassan, Christina Nilsson, H Olsson
Publikováno v:
British Journal of Clinical Pharmacology. 48:669-677
Aims This study investigated the pharmacokinetics of cyclophosphamide (CP) and its main metabolite 4-hydroxycyclophosphamide (4-OH-CP) in patients with breast cancer undergoing high dose chemothera ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e85de2429aa4e0b9a856832134acc38
https://doi.org/10.1046/j.1365-2125.1999.00090.x
https://doi.org/10.1046/j.1365-2125.1999.00090.x
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 730:177-182
The chemical substance 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) is in clinical use for the treatment of hereditary tyrosinemia type 1. In the present study, the plasma concentration of NTBC was determined by a coupled column l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1056106b312e3afbe9d6203bd756b71b
https://doi.org/10.1016/s0378-4347(99)00199-1
https://doi.org/10.1016/s0378-4347(99)00199-1
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb38b9fd4df9e2482a327e6c729f2c6
https://doi.org/10.1002/(sici)1520-667x(1998)10:7<589::aid-mcs5>3.0.co
https://doi.org/10.1002/(sici)1520-667x(1998)10:7<589::aid-mcs5>3.0.co
Autor:
Sally A. Price, Annabelle Heier, David B. Stong, Mausumee Guha, Thomas R. Simpson, Margareta Bielenstein, Daniel I. Heathcote, Elmarie Bodes, Robert Caccese
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 120(2)
Drug-induced kidney injury (DIKI) results in attrition during drug development; new DIKI urinary biomarkers offer potential to detect and monitor DIKI progression and regression, but frequently only in rats. The triple reuptake inhibitor (TRI) PRC200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4856a88777c7c363fad8e1907a53572
https://pubmed.ncbi.nlm.nih.gov/21258088
https://pubmed.ncbi.nlm.nih.gov/21258088
Autor:
L Astner, Susanna Kumlien Georén, Zuzana Hassan, G Oberg, Mohamed Abdel-Rehim, Moustapha Hassan, Margareta Bielenstein, O Ringdén, P Ljungman, Christina Nilsson, Albert N. Békássy
Publikováno v:
Karolinska Institutet
Scopus-Elsevier
Scopus-Elsevier
Busulphan and cyclophosphamide (Bu/CP) are widely used in preparative regimens for bone marrow transplantation. Many studies have shown a wide variation in busulphan pharmacokinetics. Moreover, higher rates of liver toxicity were reported in Bu/CP pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68fe127553fe7cec9f670644be9c1bc
https://pubmed.ncbi.nlm.nih.gov/10800057
https://pubmed.ncbi.nlm.nih.gov/10800057
Autor:
Lars L. Gustafsson, Christina Alm, Ylva Böttiger, Eva Arlander, Gunilla Ekström, Leif Bertilsson, Margareta Bielenstein, Juan Antonio Carrillo
Publikováno v:
Clinical pharmacology and therapeutics. 64(5)
Background Potential drug-drug interactions can be identified in vitro by exploring the importance of specific cytochrome P450 (CYP) isozymes for drug metabolism. The metabolism of the local anesthetic ropivacaine to 3-hydroxyropivacaine and (S)-2′
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b5a2137ecf59e9cf613dc9d24b625e
https://pubmed.ncbi.nlm.nih.gov/9834040
https://pubmed.ncbi.nlm.nih.gov/9834040
Autor:
Märit Johansson, Margareta Bielenstein
Publikováno v:
Journal of chromatography. B, Biomedical applications. 660(1)
A reversed-phase liquid chromatographic method to determine the concentration of 4-hydroxycyclophosphamide, a labile cytotoxic metabolite of cyclophosphamide, in plasma is described. In order to stabilize 4-hydroxycyclophosphamide, as well as to incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c218d6e530fe57d4195eec117f0c206d
https://pubmed.ncbi.nlm.nih.gov/7858703
https://pubmed.ncbi.nlm.nih.gov/7858703