Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Margareta Bergh"'
Autor:
Sanja Juric, Janet Hoogstraate, Tjerk Bueters, Margareta Bergh, Olle Gissberg, Yin Hu, Pawel Baranczewski, Jenny U. Johansson, Juliette Janson, Carrie Tsoi, Anna Breitholtz-Emanuelsson, Anders E. G. Lindgren, Sveinn Briem, Anna-Karin Sohlenius-Sternbeck, Johan Bylund
Publikováno v:
Current Drug Metabolism. 17:253-270
Background: The disposition of a drug is dependent on interactions between the body and the drug, its molecular properties and the physical and biological barriers presented in the body. In order for a drug to have a desired pharmacological effect it
Autor:
Peter Johnström, Britt-Marie Swahn, David Pyring, Magnus Schou, Margareta Bergh, Jan A.M. Neelissen, Anders Juréus, Samuel P.S. Svensson, Johan Sandell, Fredrik Jeppsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4332-4337
The synthesis and SAR of new β-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. Compounds 27, 33, and 36 displayed desirable lipophilic and pharmacokinetic properties
Publikováno v:
Contact Dermatitis. 43:82-89
Surfactants are known to be skin irritants, but change in their irritant potential due to change in composition during handling and storage has not previously been investigated. The aim of this study was to investigate the influence of oxidation prod
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 160:229-236
The solution behaviour has been investigated for an alcohol ethoxylate terminated with a formic acid ester. This compound has previously been reported to be an important degradation product in the auto-oxidation of alcohol ethoxylates. In this work w
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 150:105-113
It has previously been shown that alcohol ethoxylates readily undergo autoxidation and that one of the major oxidation products is the surfactant aldehyde, i.e. an ethoxylate carrying a –CH2CHO group at the terminal end of the polyoxyethylene chain
Autor:
Ann-Therese Karlberg, J. Lars G. Nilsson, Elisabeth Gäfvert, Margareta Bergh, Gunnel Hagelthorn, Li Ping Shao
Publikováno v:
Journal of Pharmaceutical Sciences. 87:276-282
□ Ethoxylated surfactants are susceptible to oxidation upon air exposure. We have previously studied the rate of peroxidation and formaldehyde formation in the chemically well-defined ethoxylated alcohol C12H25(OCH2CH2)5OH. Formaldehyde is a common
Autor:
Jenny Viklund, Ylva Gravenfors, Fredrik Jeppsson, Anders E. G. Lindgren, Anh Johansson, Jonas Malmström, Jan Blid, Karin J. Sterky, Annika Kers, Rickard Forsblom, Rikard Emond, Johanna Fälting, Tobias Ginman, Fredrik Rahm, Patrik Johansson, Margareta Bergh, Fredrik Lake, Fernando Sehgelmeble
Publikováno v:
Journal of medicinal chemistry. 56(11)
By use of iterative design aided by predictive models for target affinity, brain permeability, and hERG activity, novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of finding BACE-1 inhibitors as a
Autor:
Julie A. Tucker, Yvonne Lo-Alfredsson, Yvonne Nilsson, Katharina Högdin, Stefan von Berg, Jan A.M. Neelissen, Tatjana Weigelt, Eva Jerning, Margareta Bergh, Mats Ormö, Peter Söderman, Ratan Bhat, Stefan Berg, Sven Hellberg, Yafeng Xue
Publikováno v:
Journal of medicinal chemistry. 55(21)
Glycogen synthase kinase-3β, also called tau phosphorylating kinase, is a proline-directed serine/threonine kinase which was originally identified due to its role in glycogen metabolism. Active forms of GSK3β localize to pretangle pathology includi
Autor:
Britt-Marie, Swahn, Johan, Sandell, David, Pyring, Margareta, Bergh, Fredrik, Jeppsson, Anders, Juréus, Jan, Neelissen, Peter, Johnström, Magnus, Schou, Samuel, Svensson
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(13)
The synthesis and SAR of new β-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. Compounds 27, 33, and 36 displayed desirable lipophilic and pharmacokinetic properties
Autor:
Thavendran Govender, Per I. Arvidsson, Jan Johansson, Margareta Bergh, Ina Hubatsch, Urmimala Chatterjee, Hendrik G. Kruger, Partha Pratim Bose, Per Artursson
Publikováno v:
Bioorganicmedicinal chemistry. 18(16)
N-Methylation is a common strategy for improving oral bioavailability of peptide-based lead structures. Herein, we present a detailed study on how the degree of N-methylation affects the absorption-distribution-metabolism-excretion-toxicity (ADMET) p