Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Margareta Berggren"'
Autor:
Gaddam Bapu Reddy, Emmanuelle J. Meuillet, Margareta Berggren, Alan P. Kozikowski, Clifford George, Garth Powis, Haiying Sun
Publikováno v:
Tetrahedron Letters. 43:2835-2838
Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::666df9ebb35ec8a387e87cab702485ba
https://doi.org/10.1016/s0040-4039(02)00354-4
https://doi.org/10.1016/s0040-4039(02)00354-4
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:173-176
3-Modified d - myo -inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC 50 values for the inhibition of the growth of three cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6b7b7d5a97339b11aa7e96dcdfac87
https://doi.org/10.1016/s0960-894x(00)00640-5
https://doi.org/10.1016/s0960-894x(00)00640-5
Autor:
Garth Powis, D. Lynn Kirkpatrick, Margareta Berggren, William Montfort, Simon R. Hill, John R. Gasdaska, Miles Kuperus
Publikováno v:
Biochemical Pharmacology. 52:1741-1747
Thioredoxin (Trx) is a widely distributed redox protein that regulates several intracellular redox-dependent processes and stimulates the proliferation of both normal and tumor cells. We have found that when stored in the absence of reducing agents,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0078a5c6671a1f7ba192262da99aba86
https://doi.org/10.1016/s0006-2952(96)00595-3
https://doi.org/10.1016/s0006-2952(96)00595-3
Autor:
Jean Louis Samira, Emmanuelle J. Meuillet, Sivanandane Sittadjody, Zuohe Song, Randy Burd, Margareta Berggren
Epidemiological and clinical data suggest that selenium may prevent prostate cancer; however, the cellular effects of selenium in malignant prostate cells are not well understood. We previously reported that the activity of the tumor suppressor PTEN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea72229e35b96e1e54d9337f06bc0d7
https://europepmc.org/articles/PMC4049328/
https://europepmc.org/articles/PMC4049328/
Autor:
Chloe Franklin, Garth Powis, Shuxing Zhang, Daruka Mahadevan, Vijay Gokhale, Umasish Jana, Lei Du-Cuny, Margareta Berggren, Kishore Shakalya, Sylvestor A. Moses, Nikhil Shirahatti, M. Ahad Ali, Eugene A. Mash, Satya T. Narayan, Emmanuelle J. Meuillet, Nathan T. Ihle, Benjamin George
AKT, a phospholipid-binding serine/threonine kinase, is a key component of the phosphoinositide 3-kinase cell survival signaling pathway that is aberrantly activated in many human cancers. Many attempts have been made to inhibit AKT; however, selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a0ebb0f7fc40c4645786ee81ebb515
https://europepmc.org/articles/PMC2727864/
https://europepmc.org/articles/PMC2727864/
Publikováno v:
Archives of biochemistry and biophysics. 429(2)
Thioredoxin-1 (Trx-1) is a 12 kDa redox protein that is overexpressed in a large number of human tumors. Elevated Trx-1 is associated with increased tumor cell proliferation, inhibited apoptosis, aggressive tumor growth, and decreased patient surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4a979934d51f28023438c9bb4b1565
https://pubmed.ncbi.nlm.nih.gov/15313215
https://pubmed.ncbi.nlm.nih.gov/15313215
Publikováno v:
Molecular cancer research : MCR. 1(9)
Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin-2 (Trx2) as a source of reducing equivalents to scavenge hydrogen peroxide (H(2)O(2)). Low levels of H(2)O(2) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb0cba2d4f95f18adb443ac15fc8cc26
https://pubmed.ncbi.nlm.nih.gov/12861054
https://pubmed.ncbi.nlm.nih.gov/12861054
Autor:
Emmanuelle J, Meuillet, Daruka, Mahadevan, Hariprasad, Vankayalapati, Margareta, Berggren, Ryan, Williams, Amy, Coon, Alan P, Kozikowski, Garth, Powis
Publikováno v:
Molecular cancer therapeutics. 2(4)
Activation of Akt (protein kinase B), a Ser/Thr protein kinase that promotes cell survival, has been linked to tumorigenesis. Akt is activated by phosphorylation after binding of its pleckstrin homology (PH) domain to plasma membrane phosphatidyl-myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d527f3801e89a91b61f0dbdd5bedd47e
https://pubmed.ncbi.nlm.nih.gov/12700283
https://pubmed.ncbi.nlm.nih.gov/12700283
Autor:
Alfred Gallegos, Bryan Husbeck, Margareta Berggren, Amanda F. Baker, Betty K. Samulitis, Garth Powis
Publikováno v:
Archives of biochemistry and biophysics. 392(1)
Thioredoxin-1 (Trx-1) is a small redox oncoprotein whose expression is increased in a number of human primary cancers where it is associated with aggressive tumor growth, inhibition of apoptosis and decreased patient survival. We report that Trx-1-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0d04312fe3cf20bccf753620506ed1
https://pubmed.ncbi.nlm.nih.gov/11469800
https://pubmed.ncbi.nlm.nih.gov/11469800
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461351856
The mammalian thioredoxins are a family of small redox proteins that undergo NADPH dependent reduction by thioredoxin reductase. Reduced thioredoxins reduce oxidized cysteine groups on proteins including transcription factors to increase their bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d61b82da57b7f23bd8348503fd80c0f
https://doi.org/10.1007/978-1-4615-0667-6_21
https://doi.org/10.1007/978-1-4615-0667-6_21