In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for hospital acquired pneumonia

Autor: Peter J. Petersen, Margareta Tuckman, Hal Jones

Publikováno v: Infectious Disease Reports, Vol 2, Iss 1, Pp e1-e1 (2010)

The in vitro activity of tigecycline was evaluated against 819 baseline pathogens isolated from 383 patients enrolled in the phase 3 clinical trial investigating the efficacy of tigecycline in hospital acquired pneumonia (HAP). The trials were global

Externí odkaz: https://doaj.org/article/d5bd05f7ee884cad9c362cc904d9a6e4

Pyrosequencing Using the Single-Nucleotide Polymorphism Protocol for Rapid Determination of TEM- and SHV-Type Extended-Spectrum β-Lactamases in Clinical Isolates and Identification of the Novel β-Lactamase Genes bla SHV-48 , bla SHV-105 , and bla TEM-155

Autor: Peter Petersen, Patricia A. Bradford, C. Hal Jones, Margareta Tuckman, Alexey Ruzin, Melissa A. Visalli

Publikováno v: Antimicrobial Agents and Chemotherapy. 53:977-986

TEM- and SHV-type extended-spectrum β-lactamases (ESBLs) are the most common ESBLs found in the United States and are prevalent throughout the world. Amino acid substitutions at a number of positions in TEM-1 lead to the ESBL phenotype, although sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36b4d36bf8e7045b673dbb1c4c5a5b62
https://doi.org/10.1128/aac.01155-08

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction

Autor: Lee D, Jennings, Kenneth W, Foreman, Thomas S, Rush, Desiree H H, Tsao, Lidia, Mosyak, Scott L, Kincaid, Mohani N, Sukhdeo, Alan G, Sutherland, Weidong, Ding, Cynthia Hess, Kenny, Chantel L, Sabus, Hanlan, Liu, Elizabeth G, Dushin, Soraya L, Moghazeh, Pornpen, Labthavikul, Peter J, Petersen, Margareta, Tuckman, Steven A, Haney, Alexey V, Ruzin

Publikováno v: Bioorganic & Medicinal Chemistry. 12:5115-5131

The ZipA–FtsZ protein–protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41000540d428bfc3965e4aaf6d9608f0
https://doi.org/10.1016/j.bmc.2004.07.031

In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for hospital acquired pneumonia

Autor: Margareta Tuckman, C. Hal Jones, Peter Petersen

Publikováno v: Infectious Disease Reports, Vol 2, Iss 1, Pp e1-e1 (2010)
Infectious Disease Reports; Volume 2; Issue 1; Pages: e1
Infectious Disease Reports

The in vitro activity of tigecycline was evaluated against 819 baseline pathogens isolated from 383 patients enrolled in the phase 3 clinical trial investigating the efficacy of tigecycline in hospital acquired pneumonia (HAP). The trials were global

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8a315398c8068d70cc25b77d08cfc4
http://www.pagepress.org/journals/index.php/idr/article/view/1455

Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials

Autor: C Hal, Jones, Margareta, Tuckman, David, Keeney, Alexey, Ruzin, Patricia A, Bradford

Publikováno v: Antimicrobial agents and chemotherapy. 53(2)

In concert with the development of novel beta-lactams and broad-spectrum cephalosporins, bacterially encoded beta-lactamases have evolved to accommodate the new agents. This study was designed to identify, at the sequence level, the genes responsible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e96c9b2db9ff85bbe8fcc35230dd940
https://pubmed.ncbi.nlm.nih.gov/19015360