Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Margaret Y. Kawarski"'
Autor:
Margaret Y. Kawarski, Brooke Dugan, Daniel M. Kestin, Edward R. Gluzman, Amanda M. Clara, Courtney E. Duncan, Virginia J. Curtis, Gregory B. Kharas, Navely Gomez, Youya Gao, Rafaela Da Silva Bechara Soares
Publikováno v:
Journal of Macromolecular Science, Part A. 53:389-393
Novel electrophilic trisubstituted ethylenes, methyl and methoxy ring-trisubstituted butyl 2-cyano-3-phenyl-2-propenoates, RPhCH=C(CN)CO2C4H9 where R is 2,4,5-trimethyl, 2,4,6-trimethyl, 2,3-dimethyl-4-methoxy, 2,5-dimethyl-4-methoxy, 2,4-dimethoxy-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3fec01040026aa16aa80d91a8296cd
https://doi.org/10.1080/10601325.2016.1176439
https://doi.org/10.1080/10601325.2016.1176439
Publikováno v:
Chemical Biology & Drug Design. 86:1049-1054
Caspase-1 is involved in inflammatory processes and is overactive in autoimmunity and autoinflammation. Antioxidant small molecules also play a role in the immune response by decreasing inflammation. An 84-membered library of pro- and antioxidant sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2137eedc846ee2de57ae086e82c9f1d
https://doi.org/10.1111/cbdd.12572
https://doi.org/10.1111/cbdd.12572
Autor:
Margaret Y. Kawarski, Rachel C. Knopp, Gena Lenti, Magdalena Bryja, Bhabna Pati, Victor Ceja, D. Eric Walters, Caitlin E. Karver, Helen A. Gustafson, Courtney R. Kent, Emily N. Pierce
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(22)
The inflammatory caspases (caspase-1, -4 and -5) are potential therapeutic targets for autoimmune and inflammatory diseases due to their involvement in the immune response upon inflammasome formation. A series of small molecules based on the 4-(piper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5524e192b9bca91bdf023eb996cf40cd
https://pubmed.ncbi.nlm.nih.gov/27777011
https://pubmed.ncbi.nlm.nih.gov/27777011