Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Margaret Willer"'
Autor:
Edward Stack, Jeff Smith, Yasmin Hashambhoy-Ramsay, Vikki Spaulding, Michelle Priess, Kristin O’Malley, Monica Gostissa, Margaret Willer, Ben Umiker, Donald Shaffer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/945c3ea2eb844800ad50a8f0bfc39d5e
Autor:
Ben Umiker, Yasmin Hashambhoy-Ramsay, Jeff Smith, Tanzila Rahman, Amy Mueller, Rachel Davidson, Christina Meyer, Gayatri Patankar, Mohammad Murshid Alam, Sarah Jaffe, Kristin Krukenberg, Allison Goodman, Vikki Spaulding, Michelle Priess, Abha Dhaneshwar, Masie Wong, Alexa Diiorio, Kristin O'Malley, Lara McGrath, Margaret Willer, Lauren Pepper, Monica Gostissa, Katalin Kis-Toth, Dmitri Wiederschain, Heather Cohen, Donald R. Shaffer
Publikováno v:
Molecular Cancer Therapeutics. 22:471-484
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Sensitivity of LILRB2 as a predictive biomarker for pharmacodynamic response as measured by the macrophage polarization score in histoculture explant cultures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7300803b6c2959ff55929ff818f38977
https://doi.org/10.1158/1535-7163.22551994.v1
https://doi.org/10.1158/1535-7163.22551994.v1
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e89f1a6392cc21d33474e1853be7817
https://doi.org/10.1158/1535-7163.c.6534805.v1
https://doi.org/10.1158/1535-7163.c.6534805.v1
Autor:
Donald R. Shaffer, Vikki Spaulding, Edward C. Stack, Kristin Shanea O'malley, Jeffrey W. Smith, Ben Umiker, Margaret Willer, Michelle Priess, Monica Gostissa, Yasmin Hashambhoy-Ramsay
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4) is an immunoinhibitory protein expressed on the surface of myeloid cells that has been increasingly recognized as a therapeutic target of interest in immuno-oncology (IO). Upon bindi
Autor:
Kristin Shanea O'malley, Mark Yore, Reva Shenwai, Ben Umiker, Jeffrey W. Smith, Johan Baeck, Kristen Legendre, Lara McGrath, Allison L Naumovski, Margaret Willer, Tanzila Rahman, Andrew Dunn, Edward C. Stack, Amy Mueller
Publikováno v:
Cancer Research. 81:1727-1727
Leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4) is expressed on myeloid cells and inhibits myeloid cell activation through binding Major Histocompatibility class I (MHC-I) molecules. These include Human Leukocyte Antigen-G (HLA-G), which is
Autor:
Donald R. Shaffer, Seema Naheed, Chang-Ai Xu, Michael A. Meehl, Jessica Weaver, Monica Gostissa, Edward C. Stack, Joshua Adam Buggé, Masie Wong, Yan Zhang, Vikki Spaulding, Margaret Willer, Alessandro Mora, Anirudh Singh, Kristan Meetze, Lara McGrath, Boris Klebanov, Christine Fregeau, Fabien Dépis, Dhruvkumar Upadhyay, Michelle Priess, Changyun Hu, Ben Umiker, Kristin Legendre
Publikováno v:
Cancer Research. 80:4532-4532
Introduction: Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers, still most patients do not respond to PD-1 or CTLA-4 inhibitors. Thus, new Immuno-Oncology (IO) therapies that could potentially benefit non-responding p
Autor:
Heather Cohen, Yasmin Hashambhoy-Ramsay, Lauren R. Pepper, Jeffrey Y. Smith, Margaret Willer, Kevin Guay, Vikki Spaulding, Kristin O'Malley, Monica Gostissa, Abha Dhaneshwar, Edward C. Stack, Alessandro Mora, Donald R. Shaffer
Publikováno v:
Cancer Research. 79:5007-5007
Introduction: Jounce has generated cell type-specific gene signatures as a means of probing The Cancer Genome Atlas and other large datasets to identify targets that may be important immune checkpoints. Using a tumor-associated macrophage (TAM) gene