Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Margaret T Fuller"'
Autor:
Amelie A Raz, Gabriela S Vida, Sarah R Stern, Sharvani Mahadevaraju, Jaclyn M Fingerhut, Jennifer M Viveiros, Soumitra Pal, Jasmine R Grey, Mara R Grace, Cameron W Berry, Hongjie Li, Jasper Janssens, Wouter Saelens, Zhantao Shao, Chun Hu, Yukiko M Yamashita, Teresa Przytycka, Brian Oliver, Julie A Brill, Henry Krause, Erika L Matunis, Helen White-Cooper, Stephen DiNardo, Margaret T Fuller
Publikováno v:
eLife, Vol 12 (2023)
Proper differentiation of sperm from germline stem cells, essential for production of the next generation, requires dramatic changes in gene expression that drive remodeling of almost all cellular components, from chromatin to organelles to cell shap
Externí odkaz:
https://doaj.org/article/91eec495b5aa4ecead1db3f95a359e72
Autor:
Benjamin Angulo, Shrividhya Srinivasan, Benjamin J Bolival, Gonzalo H Olivares, Allyson C Spence, Margaret T Fuller
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008187 (2019)
Active adult stem cells maintain a bipotential state with progeny able to either self-renew or initiate differentiation depending on extrinsic signals from the surrounding microenvironment. However, the intrinsic gene regulatory networks and chromati
Externí odkaz:
https://doaj.org/article/89bf95e74aca46b4b0b4e29fef5162f8
Autor:
Alexis S Bailey, Pedro J Batista, Rebecca S Gold, Y Grace Chen, Dirk G de Rooij, Howard Y Chang, Margaret T Fuller
Publikováno v:
eLife, Vol 6 (2017)
The switch from mitosis to meiosis is the key event marking onset of differentiation in the germline stem cell lineage. In Drosophila, the translational repressor Bgcn is required for spermatogonia to stop mitosis and transition to meiotic prophase a
Externí odkaz:
https://doaj.org/article/c1bb0fbf955f4358a4ae2280819dbc35
Autor:
Chenggang Lu, Margaret T Fuller
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005701 (2015)
Onset of terminal differentiation in adult stem cell lineages is commonly marked by robust activation of new transcriptional programs required to make the appropriate differentiated cell type(s). In the Drosophila male germ line stem cell lineage, th
Externí odkaz:
https://doaj.org/article/d6f41d8668424c3087b005b6c67752c5
Autor:
Maria Grazia Giansanti, Timothy E Vanderleest, Cayla E Jewett, Stefano Sechi, Anna Frappaolo, Lacramioara Fabian, Carmen C Robinett, Julie A Brill, Dinah Loerke, Margaret T Fuller, J Todd Blankenship
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005632 (2015)
Mitotic and cytokinetic processes harness cell machinery to drive chromosomal segregation and the physical separation of dividing cells. Here, we investigate the functional requirements for exocyst complex function during cell division in vivo, and d
Externí odkaz:
https://doaj.org/article/8de4ad93216a4a009f11ce4bc5ab5cda
Autor:
Stefano Sechi, Gianni Colotti, Giorgio Belloni, Vincenzo Mattei, Anna Frappaolo, Grazia D Raffa, Margaret T Fuller, Maria Grazia Giansanti
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004305 (2014)
The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors. However, the
Externí odkaz:
https://doaj.org/article/c08b3dd3d1ff4ffc86e1e98d9f7cc5ea
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003903 (2013)
Many tissues are sustained by adult stem cells, which replace lost cells by differentiation and maintain their own population through self-renewal. The mechanisms through which adult stem cells maintain their identity are thus important for tissue ho
Externí odkaz:
https://doaj.org/article/4a7c932db3904ae9abe0669f4fb0bd37
Autor:
Suresh Cuddapah, Tae-Young Roh, Kairong Cui, Cynthia C Jose, Margaret T Fuller, Keji Zhao, Xin Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36365 (2012)
Polycomb group (PcG) proteins are key chromatin regulators implicated in multiple processes including embryonic development, tissue homeostasis, genomic imprinting, X-chromosome inactivation, and germ cell differentiation. The PcG proteins recognize
Externí odkaz:
https://doaj.org/article/0ec31e6e88604434af8164548d1f6b01
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52892 (2012)
Adult stem cells are essential for the proper function of many tissues, yet the mechanisms that maintain the proper identity and regulate proliferative capacity in stem cell lineages are not well understood. Polycomb group (PcG) proteins are transcri
Externí odkaz:
https://doaj.org/article/d8e370234bd74244a1fb8e4fa9369062
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12473 (2010)
Many adult stem cells reside in a special microenvironment known as the niche, where they receive essential signals that specify stem cell identity. Cell-cell adhesion mediated by cadherin and integrin plays a crucial role in maintaining stem cells w
Externí odkaz:
https://doaj.org/article/424d9eb6d6644934b5bf32390d97dec6