Výsledky vyhledávání - "Margaret Sutcliffe"

Different Patterns of Mast Cells Distinguish Diffuse from Encapsulated Neurofibromas in Patients with Neurofibromatosis 1

Autor: Tracy Tucker, Margaret Sutcliffe, Pierre Wolkenstein, Juergen R. Vielkind, Janine Wechsler, Jan M. Friedman, Vincent M. Riccardi

Publikováno v: Journal of Histochemistry & Cytochemistry. 59:584-590

Multiple neurofibromas are cardinal features of neurofibromatosis 1 (NF1). Several different types of NF1-associated neurofibromas occur, each distinct in terms of pathological details, clinical presentation, and natural history. Mast cells are prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19af7847c41c30fc02ac176b399bc3a3
https://doi.org/10.1369/0022155411407340

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Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

Autor: Margaret Sutcliffe, Lorena Barclay, Christopher M. Overall, Ulrich auf dem Keller, Shoukat Dedhar, Paul C. McDonald, Olena Preobrazhenska, Calvin D. Roskelley, Yuanmei Lou

Publikováno v: Developmental Dynamics. 237:2755-2768

Epithelial-mesenchymal transition (EMT) has been linked to metastatic propensity. The 4T1 tumor is a clinically relevant model of spontaneous breast cancer metastasis. Here we characterize 4T1-derived cell lines for EMT, in vitro invasiveness and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ee8efc7e5a261d74b006454d3dd067
https://doi.org/10.1002/dvdy.21658

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Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression–Related Changes

Autor: Jean-Claude Cutz, Margaret Sutcliffe, Hui Xue, Stephen Lam, Jun Guan, Maisa Yoshimoto, Peter W. Gout, Yuzhuo Wang, Jean C. LeRiche, John Yee, Julia Flint, Jane Bayani, Jeremy A. Squire, John C. English

Publikováno v: Clinical Cancer Research. 12:4043-4054

Purpose: Lung cancer is a biologically diverse disease and relevant models reflecting its diversity would facilitate the improvement of existing therapies. With a view to establishing such models, we developed and evaluated xenografts of a variety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0b042f8df7c9ee9a96672e0cd22eca
https://doi.org/10.1158/1078-0432.ccr-06-0252

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S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas

Autor: Juergen Vielkind, Pierre Wolkenstein, Janine Wechsler, Vincent M. Riccardi, Jan M. Friedman, Tracy Tucker, Carolyn J. Brown, Margaret Sutcliffe, John Fee

Publikováno v: Journal of neuroscience research. 89(9)

Neurofibromatosis 1 (NF1) is an autosomal dominant disease that predisposes individuals to developing benign neurofibromas. Some features and consequences of NF1 appear to result from partial deficiency of neurofibromin (Nfn), the NF1 gene protein pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946387b7b78d02c43988b857523d7a42
https://pubmed.ncbi.nlm.nih.gov/21674567

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Protein profiling of microdissected prostate tissue links growth differentiation factor 15 to prostate carcinogenesis

Autor: Douglas Webber, Hans Adomat, Peter K. Cheung, Bruce Woolcock, Juergen R. Vielkind, Marianne D. Sadar, Thomas Kinahan, Martin E. Gleave, Margaret Sutcliffe, Terry C. Bainbridge, Edward C. Jones

Publikováno v: Cancer research. 64(17)

Identification of proteomic alterations associated with early stages in the development of prostate cancer may facilitate understanding of progression of this highly variable disease. Matched normal, high-grade prostatic intraepithelial neoplasia (hP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843ddb00358e331f8a668ea3e27ab511
https://pubmed.ncbi.nlm.nih.gov/15342369

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Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models

Autor: Cheng-Han Lee, Hui Xue, Margaret Sutcliffe, Dianne Miller, Peter W. Gout, Yuzhuo Wang, C. Blake Gilks, David G. Huntsman

Publikováno v: Gynecologic oncology. 96(1)

To evaluate subrenal capsule xenografting of primary ovarian tumor tissues in mice for development of new ovarian cancer models.Pieces (1 x 3 x 3 mm) of ovarian tumor specimens from patients were meticulously grafted under renal capsules of female NO

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https://pubmed.ncbi.nlm.nih.gov/15589579

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The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

Autor: William H. Colledge, Steven McKinney, Steven S.S. Poon, Angela Burleigh, Pat Allard, Damian Yap, Gulisa Turashvili, Leah M Prentice, David G. Huntsman, Teresa Ruiz de Algara, John Fee, Margaret Sutcliffe, Xavier d'Anglemont de Tassigny, Samuel Aparicio

Publikováno v: BMC Genomics
BMC Genomics, Vol 12, Iss 1, p 209 (2011)

Background Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea15a4b511ad1d5523872938c64f3cc6
http://europepmc.org/articles/PMC3111392

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