Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Margaret Seidenberg"'
Autor:
Rabindra V. Shivnaraine, Brendan Kelly, Gwendolynne Elmslie, Xi-Ping Huang, Yue John Dong, Margaret Seidenberg, James W. Wells, John Ellis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Many G protein-coupled receptors (GPCRs) are therapeutic targets, with most drugs acting at the orthosteric site. Some GPCRs also possess allosteric sites, which have become a focus of drug discovery. In the M2 muscarinic receptor, allosteri
Externí odkaz:
https://doaj.org/article/68b8f45abdf448c890100bc734c1f038
Publikováno v:
Biochemistry. 51:4518-4540
Muscarinic cholinergic receptors contain two topographically distinct sites: an orthosteric site that binds agonists and regulates signaling, and an allosteric site that binds modulators such as gallamine and alcuronium (1). The orthosteric site is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d95c4ed4fa0569437509b0cd81b834
https://doi.org/10.1021/bi3000287
https://doi.org/10.1021/bi3000287
Publikováno v:
Molecular Pharmacology. 56:1245-1253
Gallamine allosterically modulates the binding of classical muscarinic ligands with a potency order of M(2)M(1),M(4)M(3), M(5). We have suggested previously that the M(2)/M(5) and M(2)/M(3) selectivities are attributable to an epitope in the sixth tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0adfe9105c79a7ffc34e2bcc4c9c40d
https://doi.org/10.1124/mol.56.6.1245
https://doi.org/10.1124/mol.56.6.1245
Autor:
Margaret Seidenberg, John Ellis
Publikováno v:
Molecular pharmacology. 58(6)
A series of ligands that allosterically modulate the binding of classical ligands to muscarinic receptors was evaluated at wild-type and chimeric receptors. All of the ligands studied had highest affinity toward the M(2) subtype and lowest affinity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d0d7369200ca73d96aeba92c0db986
https://pubmed.ncbi.nlm.nih.gov/11093785
https://pubmed.ncbi.nlm.nih.gov/11093785
Autor:
Margaret Seidenberg, John Ellis
Publikováno v:
Pharmacology. 61(2)
The structural basis for the selectivity of the antagonist UH-AH 37 at human muscarinic acetylcholine receptors was investigated by expressing mutant receptors in COS-7 cells. Previous studies have demonstrated that the interaction between UH-AH 37 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8845d5765a3dfde7bd5ba2af0c3fed26
https://pubmed.ncbi.nlm.nih.gov/10940778
https://pubmed.ncbi.nlm.nih.gov/10940778
Autor:
Margaret Seidenberg, John Ellis
Publikováno v:
European Journal of Pharmacology. 144:39-44
The quaternary antagonist gallamine discriminates subpopulations of muscarinic receptors in the forebrain and brainstem of the rat and also modulates the binding of other muscarinic ligands via an allosteric mechanism in both brain regions. The calci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6d3c2199e270126edcd962ffed6b5d
https://doi.org/10.1016/0014-2999(87)90006-9
https://doi.org/10.1016/0014-2999(87)90006-9