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pro vyhledávání: '"Margaret S. Ricci"'
Autor:
Pavel V. Bondarenko, Andrew C. Nichols, Gang Xiao, Rachel Liuqing Shi, Pik Kay Chan, Thomas M Dillon, Fernando Garces, David J. Semin, Margaret S. Ricci
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Therapeutic proteins including antibodies and Fc-fusion proteins undergo a large number of chemical modifications during cell culture, purification, storage and in human circulation. They are also exposed to harsh conditions during stress studies, in
Externí odkaz:
https://doaj.org/article/0330ec830a86486d90f0c24ba833c6c6
Autor:
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Arnold McAuley, Margaret S. Ricci, Pavel V. Bondarenko
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins. The method presented here describes the criticality assessment of therapeutic antibody modi
Externí odkaz:
https://doaj.org/article/78a167f61e154861acb1caacdd4ef313
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Recently, cation exchange chromatography (CEX) using aqueous volatile buffers was directly coupled with mass spectrometry (MS) and applied for intact analysis of therapeutic proteins and antibodies. In our study, chemical modifications responsible fo
Externí odkaz:
https://doaj.org/article/9c99e54a1a314a89a461b32fdff38509
Autor:
Xiaoyan Guan, Tamer Eris, Le Zhang, Da Ren, Margaret S. Ricci, Tiffany Thiel, Chetan T. Goudar
Publikováno v:
Analytical biochemistry. 643
During the manufacturing of therapeutic proteins, Critical Quality Attributes (CQAs) have been monitored by conventional methods, such as cation exchange chromatography (CEX), reduced capillary electrophoresis-sodium dodecyl sulfate (rCE-SDS), and 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71779c3103e636fe54c99e4c1352a662
https://pubmed.ncbi.nlm.nih.gov/35085546
https://pubmed.ncbi.nlm.nih.gov/35085546