Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Margaret S. Cooper"'
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Akademický článek
In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart
Autor: Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H. Josephs, Heather J. Bax, Amy E. Gilbert, Tihomir S. Dodev, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Jitesh Chauhan, Julia E. Blower, Margaret S. Cooper, James Spicer, Sophia N. Karagiannis, Philip J. Blower
Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in o
Externí odkaz: https://doaj.org/article/59a0d8fd7d8e4872844a46ea0fa1a73b
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2
Optimal His-Tag Design for Efficient [99mTc(CO)3]+ and [188Re(CO)3]+ Labeling of Proteins for Molecular Imaging and Radionuclide Therapy by Analysis of Peptide Arrays
Autor: Philip J. Blower, Margaret S. Cooper, Jennifer D Williams, Gregory E. D. Mullen, Kevin Howland, Adam Badar, Florian Kampmeier
Publikováno v: Bioconjugate Chemistry. 32:1242-1254
Hexahistidine tags (His-tags), incorporated into recombinant proteins to facilitate purification using metal-affinity chromatography, are useful binding sites for radiolabeling with [99mTc(CO)3]+ and [188Re(CO)3]+ for molecular imaging and radionucli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7158e874d2ed9bbc1718da7807eb3151
https://doi.org/10.1021/acs.bioconjchem.0c00561
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3
In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart
Autor: Giulia Chiarruttini, Alexander Koers, Margaret S. Cooper, Francis Man, Panagiotis Karagiannis, Julia E. Blower, James Spicer, Amy E. Gilbert, Tihomir Dodev, Philip J. Blower, Jitesh Chauhan, Sophia N. Karagiannis, Silvia Mele, Silvia Crescioli, Heather J. Bax, Debra H. Josephs
Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
Man, F, Koers, A, Karagiannis, P, Josephs, D H, Bax, H J, Gilbert, A E, Dodev, T S, Mele, S, Chiarruttini, G, Crescioli, S, Chauhan, J, Blower, J E, Cooper, M S, Spicer, J, Karagiannis, S N & Blower, P J 2021, ' In vivo trafficking of a tumor-targeting IgE antibody : molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart ', OncoImmunology, vol. 10, no. 1, 1966970 . https://doi.org/10.1080/2162402X.2021.1966970
IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0856e17177e24d0a8d9af14a41fc2d39
https://doi.org/10.1080/2162402x.2021.1966970
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4
In-Cell Activation of Organo-Osmium(II) Anticancer Complexes
Autor: Russell J. Needham, Carlos Sanchez-Cano, Xin Zhang, Isolda Romero-Canelón, Abraha Habtemariam, Margaret S. Cooper, Levente Meszaros, Guy J. Clarkson, Philip J. Blower, Peter J. Sadler
Publikováno v: Angewandte Chemie (International Ed. in English)
The family of iodido OsII arene phenylazopyridine complexes [Os(η6 -p-cym)(5-R1-pyridylazo-4-R2 -phenyl))I]+ (where p-cym = para-cymene) exhibit potent sub-micromolar antiproliferative activity towards human cancer cells and are active in vivo. Thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172dd7ffa3d9c328fe6f3cc0699c35da
https://doi.org/10.1002/anie.201610290
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The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator
Autor: Margaret S. Cooper, Andrew Cakebread, Michelle T. Ma, Jennifer D. Young, Ruslan Cusnir, Philip J. Blower
Publikováno v: Cusnir, R, Cakebread, A, Cooper, M S, Young, J, Blower, P J & Ma, M T 2019, ' The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator ', RSC Advances, vol. 9, no. 64, pp. 37214-37221 . https://doi.org/10.1039/C9RA07723E
GMP-grade 68Ge/ 68Ga generators provide access to positron-emitting 68Ga, enabling preparation of Positron Emission Tomography (PET) tracers and PET imaging at sites that do not have access to cyclotron-produced radionuclides. Radiotracers based on t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7769593e50177446a29745b83a87cf7b
https://kclpure.kcl.ac.uk/ws/files/123486187/The_effects_of_trace_CUSNIR_Accepted25October2019_Published14November2019_GOLD_VoR_CC_BY_.pdf
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6
In vitro cytotoxicity of Auger electron-emitting [
Autor: Muhamad Faiz Bin, Othman, Elise, Verger, Ines, Costa, Meena, Tanapirakgul, Margaret S, Cooper, Cinzia, Imberti, Valerie J, Lewington, Philip J, Blower, Samantha Y A, Terry
Publikováno v: Nuclear medicine and biology
Introduction Molecular radiotherapy exploiting short-range Auger electron-emitting radionuclides has potential for targeted cancer treatment and, in particular, is an attractive option for managing micrometastatic disease. Here, an approach using che
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f06f9262f9df9ab91897ebb630d079fc
https://pubmed.ncbi.nlm.nih.gov/31889612
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7
Evaluation of Radiopharmaceutical Adverse Reaction Reports to the British Nuclear Medicine Society from 2007 to 2016
Autor: Moez Trabelsi, Tracia-Gay Kennedy-Dixon, Sobhan Vinjamuri, Margaret S. Cooper, Maxine Gossell-Williams
Publikováno v: Journal of Nuclear Medicine. 58:2010-2012
This study sought to answer the calls that have been made for the European Association of Nuclear Medicine to restore its surveys of reported adverse reactions. We assessed all reports of adverse reactions to radiopharmaceuticals that were submitted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcccb3d4a222a1293cda1ab0b49871fe
https://doi.org/10.2967/jnumed.117.194092
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8
Aspirin-induced histone acetylation in endothelial cells enhances synthesis of the secreted isoform of netrin-1 thus inhibiting monocyte vascular infiltration
Autor: Alkystis Phinikaridou, Alessio Alfieri, Gabriella Passacquale, Christina M. Warboys, Begoña Lavin, René M. Botnar, Albert Ferro, Margaret S. Cooper, Marcelo E. Andia
Publikováno v: British Journal of Pharmacology. 172:3548-3564
Background and Purpose There are conflicting data regarding whether netrin-1 retards or accelerates atherosclerosis progression, as it can lead either to monocyte repulsion from or retention within plaques depending on its cellular source. We investi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a37888e9554679417b05ef73f3641f4d
https://doi.org/10.1111/bph.13144
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9
Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment
Autor: Rebekka Hueting, Hannah Smith, Jae Jin Lee, Margaret S. Cooper, Michel Eisenblaetter, Manuel Rodriguez-Justo, Fabian Flores-Borja, Andrew Tutt, Johannes Roth, Thomas Vogl, Christina Wefers, Tony Ng, Philip J. Blower, Hanna Milewicz, Dominic Patel, Tobias Schaeffter
Publikováno v: Theranostics, 7, 2392-2401
Eisenblaetter, M, Flores-Borja, F, Lee, J J, Wefers, C, Smith, H, Hueting, R, Cooper, M S, Blower, P J, Patel, D, Rodriguez-Justo, M, Milewicz, H, Vogl, T, Roth, J, Tutt, A, Schaeffter, T & Ng, T 2017, ' Visualization of tumor-immune interaction : Target-specific imaging of S100A8/A9 reveals pre-metastatic niche establishment ', Theranostics, vol. 7, no. 9, pp. 2392-2401 . https://doi.org/10.7150/thno.17138, https://doi.org/10.7150/thno.17138
Theranostics, 7, 9, pp. 2392-2401
Contains fulltext : 178051.pdf (Publisher’s version ) (Open Access) Background Systemic cancer spread is preceded by the establishment of a permissive microenvironment in the target tissue of metastasis - the premetastatic niche. As crucial players
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0e02df6dd31c9d5349ade628631954
http://hdl.handle.net/2066/178051
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10
PET/CT and MR imaging biomarker of lipid-rich plaques using [64Cu]-labeled scavenger receptor (CD68-Fc)
Autor: Götz Münch, René M. Botnar, Marcelo E. Andia, Philip J. Blower, Andreas Schuster, Margaret S. Cooper, David C. Onthank, Boris Bigalke, Thomas Wurster, Meinrad Gawaz, Alkystis Phinikaridou, Eike Nagel
Publikováno v: International Journal of Cardiology. 177:287-291
Continued uptake of modified low-density lipoproteins (LDL) by the scavenger receptor, CD68, of activated macrophages is a crucial process in the development of atherosclerotic plaques and leads to the formation of foam cells. Eight-weeks-old male Ap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5da568977e188f87884b05ae9cb193
https://doi.org/10.1016/j.ijcard.2014.09.017
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