In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart

Autor: Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H. Josephs, Heather J. Bax, Amy E. Gilbert, Tihomir S. Dodev, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Jitesh Chauhan, Julia E. Blower, Margaret S. Cooper, James Spicer, Sophia N. Karagiannis, Philip J. Blower

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)

IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in o

Externí odkaz: https://doaj.org/article/59a0d8fd7d8e4872844a46ea0fa1a73b

In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart

Autor: Giulia Chiarruttini, Alexander Koers, Margaret S. Cooper, Francis Man, Panagiotis Karagiannis, Julia E. Blower, James Spicer, Amy E. Gilbert, Tihomir Dodev, Philip J. Blower, Jitesh Chauhan, Sophia N. Karagiannis, Silvia Mele, Silvia Crescioli, Heather J. Bax, Debra H. Josephs

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
Man, F, Koers, A, Karagiannis, P, Josephs, D H, Bax, H J, Gilbert, A E, Dodev, T S, Mele, S, Chiarruttini, G, Crescioli, S, Chauhan, J, Blower, J E, Cooper, M S, Spicer, J, Karagiannis, S N & Blower, P J 2021, ' In vivo trafficking of a tumor-targeting IgE antibody : molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart ', OncoImmunology, vol. 10, no. 1, 1966970 . https://doi.org/10.1080/2162402X.2021.1966970

IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0856e17177e24d0a8d9af14a41fc2d39
https://doi.org/10.1080/2162402x.2021.1966970

In vitro cytotoxicity of Auger electron-emitting [67Ga]Ga-trastuzumab

Autor: Elise Verger, Cinzia Imberti, Muhamad Faiz Othman, Philip J. Blower, Samantha Y.A. Terry, Ines M. Costa, Val Lewington, Margaret S. Cooper, Meena Tanapirakgul

Publikováno v: Bin Othman, M F, Verger, E, Costa, I, Tanapirakgul, M, Cooper, M S, Imberti, C, Lewington, V J, Blower, P J & Terry, S Y A 2019, ' In vitro cytotoxicity of Auger electron-emitting [ 67 Ga]Ga-trastuzumab ', Nuclear Medicine and Biology . https://doi.org/10.1016/j.nucmedbio.2019.12.004

Introduction: Molecular radiotherapy exploiting short-range Auger electron-emitting radionuclides has potential for targeted cancer treatment and, in particular, is an attractive option for managing micrometastatic disease. Here, an approach using ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a97a4b05d350d67532faefdd50bf80
https://kclpure.kcl.ac.uk/ws/files/122130723/In_vitro_cytotoxicity_of_OTHMAN_Accepted12December2019Publishedonline13December2019_GOLD_CP_CC_BY_.pdf

The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator

Autor: Margaret S. Cooper, Andrew Cakebread, Michelle T. Ma, Jennifer D. Young, Ruslan Cusnir, Philip J. Blower

Publikováno v: Cusnir, R, Cakebread, A, Cooper, M S, Young, J, Blower, P J & Ma, M T 2019, ' The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator ', RSC Advances, vol. 9, no. 64, pp. 37214-37221 . https://doi.org/10.1039/C9RA07723E

GMP-grade 68Ge/ 68Ga generators provide access to positron-emitting 68Ga, enabling preparation of Positron Emission Tomography (PET) tracers and PET imaging at sites that do not have access to cyclotron-produced radionuclides. Radiotracers based on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7769593e50177446a29745b83a87cf7b
https://kclpure.kcl.ac.uk/ws/files/123486187/The_effects_of_trace_CUSNIR_Accepted25October2019_Published14November2019_GOLD_VoR_CC_BY_.pdf

Evaluation of Radiopharmaceutical Adverse Reaction Reports to the British Nuclear Medicine Society from 2007 to 2016

Autor: Moez Trabelsi, Tracia-Gay Kennedy-Dixon, Sobhan Vinjamuri, Margaret S. Cooper, Maxine Gossell-Williams

Publikováno v: Journal of Nuclear Medicine. 58:2010-2012

This study sought to answer the calls that have been made for the European Association of Nuclear Medicine to restore its surveys of reported adverse reactions. We assessed all reports of adverse reactions to radiopharmaceuticals that were submitted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcccb3d4a222a1293cda1ab0b49871fe
https://doi.org/10.2967/jnumed.117.194092