Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Margaret R. Pancost"'
Autor:
Jie Shi, Vinayak Hosagrahara, Keith A. Koch, Lihua Yang, Dillon Phan, Hansjoerg Lehmann, Ophelia Ardayfio, Olga Rozhitskaya, Sarah Siska, Maurice Van Eis, Ming Qian, Taeyoung Yoon, Timothy A. McKinsey, Kimberly Beattie, Craig F. Plato, Lauren G. Monovich, Clayton Springer, Margaret R. Pancost, Anup Patnaik, Erik Meredith, Ji-Hu Zhang, Istvan J. Enyedy, Anette Von Matt, Vasumathy Rajaraman, Richard B. Vega, Wendy Lee, Nikos Pagratis, Karl Miranda, Christoph Gaul, Markus Dobler, Chang Rao, Thomas Ruppen, Na Zhu, Charles F. Jewell
Publikováno v:
Journal of Medicinal Chemistry. 53:5400-5421
A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was proposed as a potential antihypertrophic mechanism with application as a heart failure therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643c1eb2e5cd66e32ad8af6e6eca9317
https://doi.org/10.1021/jm100075z
https://doi.org/10.1021/jm100075z
Autor:
Margaret R. Pancost, Yanyi Zhu, Andrew McRiner, Jonathan E. Grob, Peter Atadja, Lewis Whitehead, Tommasi Ruben A, Travis Stams, Markus Dobler, Ping Wang, Wenlin Shao, Branko Radetich, Brian Edward Vash, Ritesh Bhanudasji Tichkule, Anup Patnaik, Michael Shultz, Tavina Claiborne
Publikováno v:
Bioorganicmedicinal chemistry. 19(15)
Herein we report the discovery of a family of novel yet simple, amino-acid derived class I HDAC inhibitors that demonstrate isoform selectivity via access to the internal acetate release channel. Isoform selectivity criteria is discussed on the basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226f867c89420283d21bf81c6617c3dc
https://pubmed.ncbi.nlm.nih.gov/21723733
https://pubmed.ncbi.nlm.nih.gov/21723733