Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Margaret R. Lindsay"'
Publikováno v:
Microbiology (Reading, England). 143(3)
A distinct type of cellular organization was found in two species of the planctomycete genus Pirellula, Pirellula marina and Pirellula staleyi. Both species possess two distinct regions within the cell which are separated by a single membrane. The ma
Autor:
Carsten Schnatwinkel, Savvas Christoforidis, Margaret R Lindsay, Sandrine Uttenweiler-Joseph, Matthias Wilm, Robert G Parton, Marino Zerial
Publikováno v:
PLoS Biology, Vol 2, Iss 9, p E261 (2004)
The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functional
Externí odkaz:
https://doaj.org/article/dfd3ddb0469b4404a341c924e27ab7af
Autor:
Janette Galea, Charles Ferguson, Matthias Floetenmeyer, Tobias Richter, Jaclyn Goh, Brad J. Marsh, Garry Morgan, Margaret R. Lindsay, Robert G. Parton
Publikováno v:
Traffic. 9:893-909
Caveolae are characteristic invaginations of the mammalian plasma membrane (PM) implicated in lipid regulation, signal transduction and endocytosis. We have employed electron microscope tomography (ET) to quantify caveolae structure-function relation
Autor:
Kai Simons, Soazig Le Lay, Margaret R. Lindsay, Teymuras V. Kurzchalia, Pascal Ferré, Isabelle Dugail, Robert G. Parton, Xavier Le Liepvre, Eric Hajduch, Christoph Thiele
Publikováno v:
Traffic. 7:549-561
We have investigated the targeting of caveolin to lipid bodies in adipocytes that express high levels of caveolins and contain well-developed lipid droplets. We observed that the lipid droplets isolated from adipocytes of caveolin-1 knock out mice co
Autor:
J. Paul Luzio, Barbara M. Mullock, Simon C. W. Richardson, Nicholas A. Bright, David E. James, Abigail Stewart, Sally R. Gray, Robert C. Piper, Margaret R. Lindsay, Paul R. Pryor
Publikováno v:
EMBO reports. 5:590-595
Both heterotypic and homotypic fusion events are required to deliver endocytosed macromolecules to lysosomes and remodel late endocytic organelles. A trans-SNARE complex consisting of Q-SNAREs syntaxin 7, Vti1b and syntaxin 8 and the R-SNARE VAMP8 ha
Autor:
Margaret R. Lindsay, Robert C. Piper, Viviane Poupon, J. Paul Luzio, Paul R. Pryor, Barbara M. Mullock
Publikováno v:
Molecular Membrane Biology. 20:141-154
Summary Lysosomes are dynamic organelles receiving membrane traffic input from the biosynthetic, endocytic and autophagic pathways. They may be regarded as storage organelles for acid hydrolases and are capable of fusing with late endosomes to form h
Autor:
Wiep Scheper, Margaret R. Lindsay, James Logue, Nelyn Soto, Karin Römisch, C.-H. Christina Cheng, Nicola Collie
Publikováno v:
Journal of cell science, 116(Part 14), 2875-2883. Company of Biologists Ltd
Secretory proteins enter the secretory pathway by translocation across the membrane of the endoplasmic reticulum (ER) via a channel formed primarily by the Sec61 protein. Protein translocation is highly temperature dependent in mesophilic organisms.
Publikováno v:
Molecular Biology of the Cell. 12:3573-3588
We have previously identified a novel family of proteins called the GGAs (Golgi-localized, γ-ear-containing, ADP-ribosylation factor-binding proteins). These proteins consist of an NH2-terminal VHS domain, followed by a GAT domain, a variable domain
Publikováno v:
Traffic. 2:631-642
Immunofluorescence and electron microscopy were used to evaluate the formation of swollen endosomes in NRK cells after treatment with wortmannin or sucrose and to study the relationship between lumenal and limiting membrane. Both treatments resulted
Autor:
Barbara M. Mullock, Margaret R. Lindsay, Paul R. Pryor, David E. James, J P Luzio, Robert C. Piper
Publikováno v:
Biochemical Society Transactions. 29:476-480
Delivery of endocytosed macromolecules to lysosomes occurs by means of direct fusion of late endosomes with lysosomes. This has been formally demonstrated in a cell-free content mixing assay using late endosomes and lysosomes from rat liver. There is