Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Margaret R. Duffy"'
Autor:
Weiheng Su, Maria I. Patrício, Margaret R. Duffy, Jakub M. Krakowiak, Leonard W. Seymour, Ryan Cawood
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Scalability, yield and quality of recombinant AAVs are a significant issue during manufacture. Here the authors describe a self-inhibiting helper plasmid strategy that improves outcomes compared to helper-free approaches.
Externí odkaz:
https://doaj.org/article/b9f6c18d18514eb388b17a1dd87ec0ce
Autor:
Eleanor M. Scott, Egon J. Jacobus, Brian Lyons, Sally Frost, Joshua D. Freedman, Arthur Dyer, Hena Khalique, William K. Taverner, Alison Carr, Brian R. Champion, Kerry D. Fisher, Len W. Seymour, Margaret R. Duffy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background Tumour-associated macrophages (TAMs) are often implicated in cancer progression but can also exert anti-tumour activities. Selective eradication of cancer-promoting (M2-like) TAM subsets is a highly sought-after goal. Here, we hav
Externí odkaz:
https://doaj.org/article/d5fee97270fd469da9e2aa78cc47e661
Autor:
Janet Lei, Egon J. Jacobus, William K. Taverner, Kerry D. Fisher, Silvio Hemmi, Katy West, Lorna Slater, Fred Lilley, Alice Brown, Brian Champion, Margaret R. Duffy, Len W. Seymour
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Background Oncolytic viruses are currently experiencing accelerated development in several laboratories worldwide, with some forty-seven clinical trials currently recruiting. Many oncolytic viruses combine targeted cytotoxicity to cancer cel
Externí odkaz:
https://doaj.org/article/44a96f0e06e746ad9b16a6d3e39bf2b3
Autor:
Joshua D Freedman, Joachim Hagel, Eleanor M Scott, Ioannis Psallidas, Avinash Gupta, Laura Spiers, Paul Miller, Nikolaos Kanellakis, Rebecca Ashfield, Kerry D Fisher, Margaret R Duffy, Leonard W Seymour
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1067-1087 (2017)
Abstract Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bi
Externí odkaz:
https://doaj.org/article/65cb8311f33a4664948ad2d02957a40c
Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus
Autor:
Sam Illingworth, Ying Di, Maxine Bauzon, Janet Lei, Margaret R. Duffy, Simon Alvis, Brian Champion, André Lieber, Terry Hermiston, Len W. Seymour, John Beadle, Kerry Fisher
Publikováno v:
Molecular Therapy: Oncolytics, Vol 5, Iss C, Pp 62-74 (2017)
Enadenotucirev is an oncolytic group B adenovirus identified by a process of bio-selection for the ability to selectively propagate in and rapidly kill carcinoma cells. It is resistant to inactivation by human blood components, potentially enabling i
Externí odkaz:
https://doaj.org/article/a7c13d435d3b499f8c2068ee8f9375b9
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Supplementary Files detailing additional experiments supporting the conclusions of the manuscript, including additional activation, cytotoxicity, and cytokine analyses. Supplementary tables contain more details on characterisation of patient biopsies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485e705c7efbfb716257f1d09ff10e04
https://doi.org/10.1158/0008-5472.22419483
https://doi.org/10.1158/0008-5472.22419483
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Time-lapse sequence of uninfected control cultures of DLD, NHDF, and T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2faf0839ee83d77b36795cc68ec037f
https://doi.org/10.1158/0008-5472.22419492.v1
https://doi.org/10.1158/0008-5472.22419492.v1
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. Here, we modified the oncolytic group B adenovirus enadenotucirev to express a stroma-targeted bisp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c1027b95bdb83ff43117766fe19c258
https://doi.org/10.1158/0008-5472.c.6510393.v1
https://doi.org/10.1158/0008-5472.c.6510393.v1
Autor:
Jiangtao Ma, Margaret R Duffy, Lin Deng, Rachel S Dakin, Taco Uil, Jerome Custers, Sharon M Kelly, John H McVey, Stuart A Nicklin, Andrew H Baker
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004673 (2015)
Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX)
Externí odkaz:
https://doaj.org/article/6ac6df5e8e0a463095cf3f42d8085f51
Autor:
Weiheng, Su, Maria I, Patrício, Margaret R, Duffy, Jakub M, Krakowiak, Leonard W, Seymour, Ryan, Cawood
Publikováno v:
Nature communications. 13(1)
Recombinant adeno-associated virus (rAAV) shows great promise for gene therapy, however scalability, yield and quality remain significant issues. Here we describe an rAAV manufacturing strategy using a 'helper' adenovirus that self-inhibits its major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa1b50925e690d21ef9eb35fea9f8dec
https://pubmed.ncbi.nlm.nih.gov/35256603
https://pubmed.ncbi.nlm.nih.gov/35256603