Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Margaret R Dunne"'
Autor:
Kiran Singh, Sita Cogan, Stefan Elekes, Dearbhla M Murphy, Sinead Cummins, Rory Curran, Zaneta Najda, Margaret R Dunne, Gráinne Jameson, Siobhan Gargan, Seamus Martin, Aideen Long, Derek G Doherty
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271463 (2022)
γδ T cells are thought to contribute to immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanisms by which they are activated by the virus are unknown. Using flow cytometry, we investigated if the two most ab
Externí odkaz:
https://doaj.org/article/5f8051546359488d8f85aea2cdba58af
Autor:
Margaret R Dunne, Louise Elliott, Seamus Hussey, Nasir Mahmud, Jacinta Kelly, Derek G Doherty, Conleth F Feighery
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76008 (2013)
Coeliac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The only current therapy is a lifelong gluten free diet. While much work has focused on the g
Externí odkaz:
https://doaj.org/article/47935f873acf495b8bb60ccafe5b81fe
Autor:
Maria E. Morrissey, Róisín Byrne, Celina Nulty, Niamh H. McCabe, Niamh Lynam-Lennon, Clare T. Butler, Susan Kennedy, Dermot O’Toole, John Larkin, Paul McCormick, Brian Mehigan, Mary-Clare Cathcart, Joanne Lysaght, John V. Reynolds, Elizabeth J. Ryan, Margaret R. Dunne, Jacintha O’Sullivan
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Only 10–30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment (TME) may enabl
Externí odkaz:
https://doaj.org/article/eac61d4bd7544b4db891309c642d064c
Autor:
Maria Davern, Noel E. Donlon, Fiona O’Connell, Caoimhe Gaughan, Cillian O’Donovan, Mohammed Habash, Andrew D. Sheppard, Michael MacLean, Margaret R. Dunne, Jenny Moore, Hugo Temperley, Melissa J. Conroy, Christine Butler, Anshul Bhardwaj, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Cancer Immunology, Immunotherapy. 72:55-71
Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study investigated the effect of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be424e297392a657451ea0876b74eede
https://doi.org/10.1007/s00262-022-03228-y
https://doi.org/10.1007/s00262-022-03228-y
Autor:
Noel E, Donlon, Maria, Davern, Fiona, O'Connell, Andrew, Sheppard, Aisling, Heeran, Anshul, Bhardwaj, Christine, Butler, Ravi, Narayanasamy, Claire, Donohoe, James J, Phelan, Niamh, Lynam-Lennon, Margaret R, Dunne, Stephen, Maher, Jacintha, O'Sullivan, John V, Reynolds, Joanne, Lysaght
Publikováno v:
World Journal of Gastroenterology. 28:2302-2319
In the contemporary era of cancer immunotherapy, an abundance of clinical and translational studies have reported radiotherapy (RT) and immunotherapies as a viable option for immunomodulation of many cancer subtypes, with many related clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5d7de08595924a4e2f5c7b697d8a48
https://doi.org/10.3748/wjg.v28.i21.2302
https://doi.org/10.3748/wjg.v28.i21.2302
Autor:
Sara Naimimohasses, Philip O’Gorman, Ciara Wright, Deirdre Ni Fhloinn, Dean Holden, Niall Conlon, Ann Monaghan, Megan Kennedy, John Gormley, Peter Beddy, Stephen Patrick Finn, Joanne Lysaght, Jacintha O’Sullivan, Margaret R. Dunne, Suzanne Norris, J. Bernadette Moore
Publikováno v:
Nutrients; Volume 14; Issue 11; Pages: 2198
Background: Mucosal-associated invariant T (MAIT) cells promote inflammation in obesity and are implicated in the progression of non-alcoholic fatty liver disease (NAFLD). However, as the intrahepatic MAIT cell response to lifestyle intervention in N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a119025532fb1c0d642c6da92284d6a9
Autor:
Aoife Nolan, Emma K. Foley, Narayanasamy Ravi, John V. Reynolds, Jacintha O'Sullivan, Susan Kennedy, Maria E Morrissey, Margaret R. Dunne, Maria Davern, F MacCarthy, Breandán N. Kennedy, Joanne Lysaght, Dermot O'Toole, Amy M. Buckley, Niamh Clarke
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant therapy with chemoradiation or chemotherapy, however the 5-year survival rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f5a251c1f9766184e12079e599b204
https://doaj.org/article/e0a0a6fa4475406c8c5b27eb5adbbaa8
https://doaj.org/article/e0a0a6fa4475406c8c5b27eb5adbbaa8
Autor:
Robert Geraghty, Aoife Maguire, Cara Dunne, Kieran Sheahan, Petra Martin, David Fennelly, Miriam Tosetto, James J. Phelan, Elizabeth J. Ryan, Jacintha O'Sullivan, Adriana J. Michielsen, Sinead Noonan, Margaret R. Dunne
Publikováno v:
Cancer Immunology, Immunotherapy
HLA-DR, an MHC class II molecule that mediates antigen presentation, is a favourable prognostic indicator in colorectal cancer (CRC). However, the dynamics and location of HLA-DR expression during CRC development are unclear. We aimed to define HLA-D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5ade1a943c52c260fbd186677ee6ae
http://europepmc.org/articles/PMC7347515
http://europepmc.org/articles/PMC7347515
Publikováno v:
European Neuropsychopharmacology. 31:131-144
Amitriptyline is prescribed for treating the symptoms of neuroinflammatory disorders including neuropathic pain and fibromyalgia. As amitriptyline has evidence of modulating the neuroimmune interface; the effects of amitriptyline treatment on T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217de69c7423f53efb2d60b2d583163b
https://doi.org/10.1016/j.euroneuro.2019.12.106
https://doi.org/10.1016/j.euroneuro.2019.12.106
Autor:
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O’Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O’Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundImmune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40404bfb50d989818faee7e2c70e4d3b
https://doi.org/10.3389/fimmu.2022.823225
https://doi.org/10.3389/fimmu.2022.823225