Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Margaret R Cunningham"'
Autor:
Jacqueline Stockley, Shaista P Nisar, Vincenzo C Leo, Essa Sabi, Margaret R Cunningham, Jeroen C Eikenboom, Stefan Lethagen, Reinhard Schneppenheim, Anne C Goodeve, Steve P Watson, Stuart J Mundell, Martina E Daly, GAPP Study in Collaboration with the MCMDM-1VWD Study Group
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143913 (2015)
The clinical expression of type 1 von Willebrand disease may be modified by co-inheritance of other mild bleeding diatheses. We previously showed that mutations in the platelet P2Y12 ADP receptor gene (P2RY12) could contribute to the bleeding phenoty
Externí odkaz:
https://doaj.org/article/11d6dee9ef184a37a4aee9385245570a
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract Co‐creation within higher education emphasizes learner empowerment to promote collaboration between the students and staff, enabling students to become active participants in their learning process and the construction of resources with ac
Externí odkaz:
https://doaj.org/article/e3c40326fbaa411d8ffc4f8e5c36953c
Publikováno v:
Biochemical Society Transactions
Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the mid-1990. Despite the advances in understanding PAR2 pharmacology, it has taken almost 25 years for the first inhibitor to reach clinical trials, and so far,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799c9851c40df95c7eeb3abbfa3dcb2a
https://doi.org/10.1042/bst20200191
https://doi.org/10.1042/bst20200191
Autor:
Anna Accarino, Lucia Relea, Sara Traserra, Marcel Jiménez, Claudia Barber, Patri Vergara, Lewis C. MacPherson, Charles Kennedy, Margaret R. Cunningham, Jane Maclnnes
Background: Gastrointestinal smooth muscle relaxation is accomplished by activation of P2Y 1 receptors, therefore this receptor plays an important role in regulation of gut motility. Recently, BPTU was developed as a negative allosteric modulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0082f5ce18677b7e51be57d903a6f9bf
https://strathprints.strath.ac.uk/76419/1/Traserra_etal_2021_NM_Different_responses_of_the_blockade_of_the_P2Y1_receptor_with_BPTU_in_human_and_porcine_intestinal_tissues_and_in_cell_cultures.pdf
https://strathprints.strath.ac.uk/76419/1/Traserra_etal_2021_NM_Different_responses_of_the_blockade_of_the_P2Y1_receptor_with_BPTU_in_human_and_porcine_intestinal_tissues_and_in_cell_cultures.pdf
Autor:
Nigel J. Pyne, Rothwelle J. Tate, Federico Torta, David R. Adams, Jeongah Oh, Susan Pyne, Ryan D. R. Brown, Margaret R. Cunningham, Ben E.P. Veerman
Publikováno v:
The Journal of Biological Chemistry
The translocation of sphingosine kinase 1 (SK1) to the plasma membrane (PM) is crucial in promoting oncogenesis. We have previously proposed that SK1 exists as both a monomer and dimer in equilibrium, although it is unclear whether these species tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3396474707d566c93b76fdd17ca71c
http://europepmc.org/articles/PMC8135045
http://europepmc.org/articles/PMC8135045
Autor:
Yu Chen, David Day-Uei Li, Margaret R. Cunningham, Natakorn Sapermsap, Dong Xiao, Mohammed Safar
Publikováno v:
Frontiers in Physics
Frontiers in Physics, Vol 9 (2021)
Frontiers in Physics, Vol 9 (2021)
Time-correlated single-photon counting (TCSPC) has been the gold standard for fluorescence lifetime imaging (FLIM) techniques due to its high signal-to-noize ratio and high temporal resolution. The sensor system's temporal instrument response functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176b292a19659e5fb426108f41aba249
https://strathprints.strath.ac.uk/75356/7/Xiao_etal_FP_2021_On_synthetic_instrument_response_functions.pdf
https://strathprints.strath.ac.uk/75356/7/Xiao_etal_FP_2021_On_synthetic_instrument_response_functions.pdf
Publikováno v:
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine, Vol 7 (2021)
Frontiers in Cardiovascular Medicine, Vol 7 (2021)
Background: Tyrosine kinase inhibitors (TKIs) have dramatically improved cancer treatment but are known to cause cardiotoxicity. The pathophysiological consequences of TKI therapy are likely to manifest across different cell types of the heart, yet t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6800e5dae832f17ad1e070d7b33e70c3
https://strathprints.strath.ac.uk/75352/1/McMullen_etal_FCM_2021_Sunitinib_imatinib_display_differential_cardiotoxicity_adult_rat_cardiac_fibroblasts.pdf
https://strathprints.strath.ac.uk/75352/1/McMullen_etal_FCM_2021_Sunitinib_imatinib_display_differential_cardiotoxicity_adult_rat_cardiac_fibroblasts.pdf
Autor:
Sapermsap Natakorn, Mohammed Safar, Jinshou Tian, Margaret R. Cunningham, Yahui Li, Yu Chen, David Day-Uei Li
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Frontiers in Physics
Frontiers in Physics
Intensity- and amplitude-weighted average lifetimes, denoted as τI and τA hereafter, are useful indicators for revealing Förster resonance energy transfer (FRET) or fluorescence quenching behaviors. In this work, we discussed the differences betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c785919f19f2a4b29f22ae24453797f8
https://doi.org/10.3389/fphy.2020.576862
https://doi.org/10.3389/fphy.2020.576862
Autor:
Margaret R. Cunningham, Yvonne Dempsie, Blair F. Johnston, Ben E.P. Veerman, Samantha-Joe McGivern, Patricia Martin, Susan Currie
Publikováno v:
Heart Journal - SCF.
Introduction Anthracyclines, such as doxorubicin, remain an important class of chemotherapeutic agent however their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity. Whilst most studies have focused on cardiomyocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b8340d5546b8f7e90d578cb12cff852
https://doi.org/10.1136/heartjnl-2020-scf.11
https://doi.org/10.1136/heartjnl-2020-scf.11
Publikováno v:
Cunningham, M R, Aungraheeta, R & Mundell, S J 2017, ' Pathophysiological consequences of receptor mistraffic : Tales from the platelet P2Y12 receptor ', Molecular and Cellular Endocrinology, vol. 449, pp. 74-81 . https://doi.org/10.1016/j.mce.2017.02.016
Genetic variations in G protein-coupled receptor (GPCR) genes can disrupt receptor function in a wide variety of human genetic diseases, including platelet bleeding disorders. Platelets are critical for haemostasis with inappropriate platelet activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df0894c5e8e357fc693afc8a9460ddf
https://doi.org/10.1016/j.mce.2017.02.016
https://doi.org/10.1016/j.mce.2017.02.016