Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Margaret P Manspeaker"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Tumor-draining lymph nodes (TdLNs) are critical in the regulation of local and systemic antitumor T cell immunity and are implicated in coordinating responses to immunomodulatory therapies.Methods Biomaterial nanoparticles that deliver che
Externí odkaz:
https://doaj.org/article/3fa5f1ebad2d4f6a9079cdc62f66252e
Autor:
Jihoon Kim, David M. Francis, Lauren F. Sestito, Paul A. Archer, Margaret P. Manspeaker, Meghan J. O’Melia, Susan N. Thomas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nitric oxide exerts a multitude of physiological functions and has also been exploited for anticancer therapies. Here the authors report the design of a micelle-releasing thermosensitive hydrogel system for the concomitant locoregional and lymphatic
Externí odkaz:
https://doaj.org/article/955df8be82f34fec86bf0913efa76330
Autor:
Camila P. Camargo, Abir K. Muhuri, Yunus Alapan, Lauren F. Sestito, Megha Khosla, Margaret P. Manspeaker, Aubrey S. Smith, Chrystal M. Paulos, Susan N. Thomas
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112175- (2023)
Summary: CD8+ T cell recruitment to the tumor microenvironment is critical for the success of adoptive cell therapy (ACT). Unfortunately, only a small fraction of transferred cells home to solid tumors. Adhesive ligand-receptor interactions have been
Externí odkaz:
https://doaj.org/article/b4f20bae16a84fccbccc5487a170cc42
Autor:
Jihoon Kim, Paul A. Archer, Margaret P. Manspeaker, Alexa R.C. Avecilla, Brian P. Pollack, Susan N. Thomas
Publikováno v:
Journal of Controlled Release. 357:655-668
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13850ea6610c8510bb5c4bfc359966f7
https://doi.org/10.1016/j.jconrel.2023.04.028
https://doi.org/10.1016/j.jconrel.2023.04.028
Autor:
Zhou Yuan, Meghan J. O’Melia, Kaitao Li, Jintian Lyu, Fangyuan Zhou, Prithiviraj Jothikumar, Nathan A. Rohner, Margaret P. Manspeaker, David M. Francis, Ke Bai, Chenghao Ge, Muaz N. Rushdi, Loice Chingozha, Samuel Ruipérez-Campillo, Hang Lu, Susan N. Thomas, Cheng Zhu
CD8+ T cells underpin effective anti-tumor immune responses in melanoma; however, their functions are attenuated due to various immunosuppressive factors in the tumor microenvironment (TME), resulting in disease progression. T cell function is elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20242a410dc224aa202a531c3cfc6c8b
https://doi.org/10.1101/2022.09.11.507496
https://doi.org/10.1101/2022.09.11.507496
Publikováno v:
Cancer Immunol Immunother
Triple negative breast cancer (TNBC) is a significant clinical problem to which immunotherapeutic strategies have been applied with limited success. Using the syngeneic E0771 TNBC mouse model, this work explores the potential for anti-tumor CD8(+) T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9c7085b4816e986faae24ec8ed7979
https://doi.org/10.1007/s00262-020-02792-5
https://doi.org/10.1007/s00262-020-02792-5
Autor:
Asheley P. Chapman, Cody J. Higginson, David M. Francis, Alex Schudel, Alexa Regina Chua Avecilla, M. G. Finn, Susan N. Thomas, Mei-Kwan Yau, Nathan A. Rohner, Margaret P. Manspeaker
Publikováno v:
Nature nanotechnology
Therapeutic delivery selectively to lymph nodes has the potential to address a variety of unmet clinical needs. However, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph node reticular network, delivering c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02894f43c7b147af8c3b3433f0b125be
https://doi.org/10.1038/s41565-020-0679-4
https://doi.org/10.1038/s41565-020-0679-4
Autor:
Lauren F. Sestito, Susan N. Thomas, Nathan A. Rohner, Meghan J. O'Melia, Yajun Mei, Alex Schudel, Margaret P. Manspeaker, Paul A. Archer
Publikováno v:
Drug Deliv Transl Res
Lymph nodes (LNs) are tissues of the immune system that house leukocytes, making them targets of interest for a variety of therapeutic immunomodulation applications. However, achieving accumulation of a therapeutic in the LN does not guarantee equal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad01c45b4430c866126119b1fedd8de
https://pubmed.ncbi.nlm.nih.gov/34165731
https://pubmed.ncbi.nlm.nih.gov/34165731
Autor:
Jihoon, Kim, David M, Francis, Lauren F, Sestito, Paul A, Archer, Margaret P, Manspeaker, Meghan J, O'Melia, Susan N, Thomas
Publikováno v:
Nature communications. 13(1)
Due to their autosynchronous roles in shaping the anti-tumor immune response, complex immune regulatory networks acting both locally within the tumor microenvironment as well as in its draining lymph nodes play critical roles in the cancer immunother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fd45e0e77a993d3b06b6e8dc9c41318
https://pubmed.ncbi.nlm.nih.gov/35304456
https://pubmed.ncbi.nlm.nih.gov/35304456
Autor:
Alexander J. Heiler, Alex Schudel, Margaret P. Manspeaker, David M. Francis, Paul A. Archer, Lauren F. Sestito, Susan N. Thomas
Publikováno v:
Biomaterials
Multiple small molecule immune modulators have been identified as synergistic with immune checkpoint blockade (ICB) in their effects on T lymphocytes , but are limited in their successful application to combination cancer immunotherapy due to their s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f6b0cd5df1468c953ae7a176c93b4d
https://pubmed.ncbi.nlm.nih.gov/34678650
https://pubmed.ncbi.nlm.nih.gov/34678650