Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Margaret N. Kennedy"'
Autor:
Xinle Cui, Can Kocabas, Margaret N. Kennedy, Sunita Kanswal, Mustafa Akkoyunlu, Milan S. Blake, David M. Segal, Nora Katsenelson
Publikováno v:
Cellular Microbiology. 9:1297-1310
Encapsulated Neisseria meningitidis can invade mucosal barriers and cause systemic diseases. Activation of the innate immune system by conserved meningococcal molecules such as lipooligosaccharides (LOS) is essential for the generation of an effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9663bf656bc956719f07e46c84ce11
https://doi.org/10.1111/j.1462-5822.2006.00872.x
https://doi.org/10.1111/j.1462-5822.2006.00872.x
Autor:
Jody L. Lopez, Margaret N. Kennedy, James C. Brooks, Karin Hoelzer, Cynthia A. Leifer, David M. Segal, Alessandra Mazzoni
Publikováno v:
Journal of Biological Chemistry. 281:35585-35592
Toll-like receptors (TLRs) are essential for host defense. Although several TLRs reside on the cell surface, nucleic acid recognition of TLRs occurs intracellularly. For example, the receptor for CpG containing bacterial and viral DNA, TLR9, is retai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db85443c20c32afc3555ab949266b51
https://doi.org/10.1074/jbc.m607511200
https://doi.org/10.1074/jbc.m607511200
Autor:
Alessandra Mazzoni, Gregory E. D. Mullen, David M. Segal, Margaret N. Kennedy, Cynthia A. Leifer, David R. Davies, Alberto Visintin
Publikováno v:
Proceedings of the National Academy of Sciences. 100:3919-3924
MD-2 is a secreted glycoprotein that binds to the extracellular domain of Toll-like receptor 4 (TLR4) and is required for the activation of TLR4 by lipopolysaccharide (LPS). The protein contains seven Cys residues and consists of a heterogeneous coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff93aae1b52509612340e9ed4647cfb
https://doi.org/10.1073/pnas.0630495100
https://doi.org/10.1073/pnas.0630495100
Autor:
Jessica H. Spitzer, Alessandra Mazzoni, Margaret N. Kennedy, David M. Segal, Alberto Visintin
Publikováno v:
European Journal of Immunology. 32:1182-1187
Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, USAToll-like receptor 4 (TLR4) is the signal-transducing component of the LPS recognition com-plex and is essential for LPS-induced septic shock. Here we demonstrate that TLR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9d6fd4f55aab24342449b0921c72537
https://doi.org/10.1002/1521-4141(200204)32:4<1182::aid-immu1182>3.0.co
https://doi.org/10.1002/1521-4141(200204)32:4<1182::aid-immu1182>3.0.co
Autor:
Michael J. Kruhlak, Cynthia A. Leifer, Margaret N. Kennedy, Alessandra Mazzoni, David M. Segal, ChangWoo Lee
In mammals, 10 TLRs recognize conserved pathogen-associated molecular patterns, resulting in the induction of inflammatory innate immune responses. One of these, TLR9, is activated intracellularly by bacterial DNA and synthetic oligodeoxynucleotides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0624a325af3fb01706f8ad6aae68f82e
https://europepmc.org/articles/PMC2757936/
https://europepmc.org/articles/PMC2757936/
Autor:
Cynthia A. Leifer, Alessandra Mazzoni, Margaret N. Kennedy, David M. Segal, ChangWoo Lee, Kottarappat N. Dileepan, Gregory E. D. Mullen
Publikováno v:
The Journal of biological chemistry. 279(33)
MD-2, a glycoprotein that is essential for the innate response to lipopolysaccharide (LPS), binds to both LPS and the extracellular domain of Toll-like receptor 4 (TLR4). Following synthesis, MD-2 is either secreted directly into the medium as a solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5748c90ef32a5f2f87ffb9b3a3cae2d
https://pubmed.ncbi.nlm.nih.gov/15175334
https://pubmed.ncbi.nlm.nih.gov/15175334
Autor:
Dennis M. Klinman, Alessandra Mazzoni, Margaret N. Kennedy, David M. Segal, Gregory E. D. Mullen, Cynthia A. Leifer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 170(5)
Plasmacytoid dendritic cells (DC) are professional APC and a major source of type I IFN following viral infection. We previously showed that histamine alters the cytokine profiles of maturing monocyte-derived DC resulting in a change from Th1 to Th2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a710540cd9f4055ac87be7055a7fdc
https://pubmed.ncbi.nlm.nih.gov/12594246
https://pubmed.ncbi.nlm.nih.gov/12594246
Autor:
Jessica H, Spitzer, Alberto, Visintin, Alessandra, Mazzoni, Margaret N, Kennedy, David M, Segal
Publikováno v:
European journal of immunology. 32(4)
Toll-like receptor 4 (TLR4) is the signal-transducing component of the LPS recognition complex and is essential for LPS-induced septic shock. Here we demonstrate that TLR1 has the capacity to abrogate TLR4 signaling. Human microvascular endothelial c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f7e698aed30336ebf17ec237e72e5d7
https://pubmed.ncbi.nlm.nih.gov/11932926
https://pubmed.ncbi.nlm.nih.gov/11932926