Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Margaret Mullin"'
Autor:
Khadeejah Maeyouf, Intouch Sakpakdeejaroen, Sukrut Somani, Jitkasem Meewan, Hawraa Ali-Jerman, Partha Laskar, Margaret Mullin, Graeme MacKenzie, Rothwelle J. Tate, Christine Dufès
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2643 (2023)
Gene therapy holds great promise for treating prostate cancer unresponsive to conventional therapies. However, the lack of delivery systems that can transport therapeutic DNA and drugs while targeting tumors without harming healthy tissues presents a
Externí odkaz:
https://doaj.org/article/f0f156a639e94ad69482ba726d7aba09
Autor:
Mohammad A. Obeid, Ibrahim Khadra, Abdullah Albaloushi, Margaret Mullin, Hanin Alyamani, Valerie A. Ferro
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 1826-1832 (2019)
Curcumin, a natural chemical compound found in Curcuma longa that has been used in antitumor and anti-inflammation applications, exhibits very limited water solubility and rapid in vivo degradation, which limits its clinical application. To overcome
Externí odkaz:
https://doaj.org/article/f048b861eabd484895e0924e36f7b7e0
Autor:
Gregory Naylor, Linda Julian, Steven Watson-Bryce, Margaret Mullin, Robert J. Nibbs, Michael F. Olson
Publikováno v:
Cancers, Vol 14, Iss 23, p 5943 (2022)
The morphological changes during apoptosis help facilitate “immunologically silent” cell death. Caspase cleavage of the ROCK1 kinase results in its activation, which drives the forceful contraction of apoptotic cells. We previously showed that wh
Externí odkaz:
https://doaj.org/article/773f94e2af9d41baaed99d35c33aa97c
Autor:
Linda Julian, Gregory Naylor, Grant R Wickman, Nicola Rath, Giovanni Castino, David Stevenson, Sheila Bryson, June Munro, Lynn McGarry, Margaret Mullin, Alistair Rice, Armandodel Del Río Hernández, Michael F Olson
Publikováno v:
eLife, Vol 10 (2021)
Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase non-cleavable (ROCK1nc) by mutating aspartate 1113, which rev
Externí odkaz:
https://doaj.org/article/561313de3fc74efb82322845873c5ee6
Autor:
Jitkasem Meewan, Sukrut Somani, Partha Laskar, Craig Irving, Margaret Mullin, Stuart Woods, Craig W. Roberts, Abdullah R. Alzahrani, Valerie A. Ferro, Suzanne McGill, Stefan Weidt, Richard Burchmore, Christine Dufès
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 439 (2022)
The formation of a protein layer “corona” on the nanoparticle surface upon entry into a biological environment was shown to strongly influence the interactions with cells, especially affecting the uptake of nanomedicines. In this work, we present
Externí odkaz:
https://doaj.org/article/e26144ba918248959b2bf2ea0a028705
Autor:
Mark McCully, João Conde, Pedro V Baptista, Margaret Mullin, Matthew J Dalby, Catherine C Berry
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192562 (2018)
Mesenchymal stem cells are multipotent adult stem cells capable of generating bone, cartilage and fat, and are thus currently being exploited for regenerative medicine. When considering osteogenesis, developments have been made with regards to chemic
Externí odkaz:
https://doaj.org/article/048b971018674ad489108ef953656654
Autor:
Natasha S Lewis, Emily EL Lewis, Margaret Mullin, Helen Wheadon, Matthew J Dalby, Catherine C Berry
Publikováno v:
Journal of Tissue Engineering, Vol 8 (2017)
Multicellular spheroids are an established system for three-dimensional cell culture. Spheroids are typically generated using hanging drop or non-adherent culture; however, an emerging technique is to use magnetic levitation. Herein, mesenchymal stem
Externí odkaz:
https://doaj.org/article/21dd63f8d503480cbcd0948903e3df6d
Autor:
David Stirling, Andrew Hursthouse, Margaret Mullin, Jesus M. de la Fuente, Pablo del Pino, Carol Anne Smith, Suman Chaudhary, Catherine C. Berry
Publikováno v:
Pharmaceuticals, Vol 6, Iss 2, Pp 204-222 (2013)
Nanotechnology plays an increasingly important role in the biomedical arena. In particular, magnetic nanoparticles (mNPs) have become important tools in molecular diagnostics, in vivo imaging and improved treatment of disease, with the ultimate aim o
Externí odkaz:
https://doaj.org/article/18e73b2341d44bc68ff71769a0aa4569
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 5 (2013)
ABSTRACT - Purpose. To compare the properties of buccal delivery matrices (wafers) made with dextrin, β-limit dextrin and pre-gelatinised starch. Methods. The constituent α-glucans were tested for their mucoadhesive properties in solution plus thei
Externí odkaz:
https://doaj.org/article/4da4574ed9024052a015731e110475c8
Autor:
Joanne Haney, Swetha Vijayakrishnan, James Streetley, Kieran Dee, Daniel Max Goldfarb, Mairi Clarke, Margaret Mullin, Stephen D. Carter, David Bhella, Pablo R. Murcia
Publikováno v:
Nature Microbiology. 7:1879-1890
Interactions between respiratory viruses during infection affect transmission dynamics and clinical outcomes. To identify and characterize virus-virus interactions at the cellular level, we coinfected human lung cells with influenza A virus (IAV) and