Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Margaret M. Tarpey"'
Autor:
Brian S. Zuckerbraun, Mark T. Gladwin, Michael C. Madigan, Guiying Hong, Ankur Shukla, Ryan M. McEnaney, Margaret M. Tarpey, Edith Tzeng, Eric E. Kelley
Publikováno v:
Molecular Medicine. 21:313-322
Chronic, nonhealing wounds result in patient morbidity and disability. Reactive oxygen species (ROS) and nitric oxide (NO) are both required for normal wound repair, and derangements of these result in impaired healing. Xanthine oxidoreductase (XOR)
Autor:
Matthew J. Alef, Edith Tzeng, Mark T. Gladwin, Margaret M. Tarpey, Raghuveer Vallabhaneni, Eric E. Kelley, Brian S. Zuckerbraun, Evie H. Carchman, Sruti Shiva, Sidney M. Morris, Yinna Wang
Publikováno v:
Journal of Clinical Investigation. 121:1646-1656
Vascular disease, a significant cause of morbidity and mortality in the developed world, results from vascular injury. Following vascular injury, damaged or dysfunctional endothelial cells and activated SMCs engage in vasoproliferative remodeling and
Autor:
Christopher S. Wilcox, Yifan Chen, Stephanie Connors, James Mitchell, Kinjal Patel, William J. Welch, Jonathan Blau, Margaret M. Tarpey, Margarida Mendonca, Kathryn Dennehy, Murali Krishna
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 290:R37-R43
Tempol is an amphipathic radical nitroxide (N) that acutely reduces blood pressure (BP) and heart rate (HR) in the spontaneously hypertensive rat (SHR). We investigated the hypothesis that the response to nitroxides is determined by SOD mimetic activ
Autor:
Dale A. Parks, Margaret M. Tarpey, C. Roger White, Jonathan E. Shelton, Rakesh P. Patel, Bruce A. Freeman, Victor M. Darley-Usmar
Publikováno v:
FEBS Letters. 561:94-98
Xanthine oxidase (XO)-derived superoxide contributes to endothelial dysfunction in humans and animal models of hypercholesterolemia (HC). Since L-arginine supplementation prevents defects in NO signaling, we tested the hypothesis that L-arginine blun
Autor:
Bruce A. Freeman, Beatriz Alvarez, John D. Lang, Margaret M. Tarpey, Mutay Aslan, Rafael Radi, Phillip Chumley, Mario Figueroa, John B. Hurt
Publikováno v:
Anesthesiology. 100:51-58
Background Human serum albumin is used clinically to maintain colloid osmotic pressure and is viewed to serve an antioxidant role in the vascular compartment via binding of redox-active metal complexes, transport of nitric oxide, and the oxidant-scav
Autor:
Ines Batinic-Haberle, Dale A. Parks, J. Anthony Thompson, Mark T. Gladwin, Thomas M. Ryan, Mutay Aslan, Tim M. Townes, Bruce A. Freeman, Albert Tousson, Brian Adler, C. Roger White, Margaret M. Tarpey, Rakesh P. Patel
Publikováno v:
Proceedings of the National Academy of Sciences. 98:15215-15220
Plasma xanthine oxidase (XO) activity was defined as a source of enhanced vascular superoxide (O \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrs
Autor:
Margaret M. Tarpey, Irwin Fridovich
Publikováno v:
Circulation Research. 89:224-236
The evanescent nature of reactive oxygen and nitrogen species, the multiple cellular mechanisms evolved to maintain these substances at low (submicromolar) concentrations within the vascular system, and the often multifaceted nature of their reactivi
Autor:
Margaret M. Tarpey, Yasser Sakawi, Dale A. Parks, Yiu-Fai Chen, David H. Chestnut, David A. Calhoun, Michael G. Connor
Publikováno v:
Anesthesiology. 93:1446-1455
Background Recent evidence implicates nitric oxide (*NO) in the pathogenesis of preeclampsia. The authors tested the hypothesis that administration of low-dose endotoxin to pregnant rats mimics the signs of preeclampsia in humans and that *NO and *NO
Autor:
Rafael Radi, Margaret M. Tarpey, Bruce A. Freeman, C. Roger White, G J Richardson, Edward Suarez
Publikováno v:
Circulation Research. 84:1203-1211
Abstract —Lucigenin-amplified chemiluminescence has frequently been used to assess the formation of superoxide in vascular tissues. However, the ability of lucigenin to undergo redox cycling in purified enzyme-substrate mixtures has raised question
Autor:
Josiah N. Wilcox, Catherine Huraux, Fania Szlam, David G. Harrison, Jerrold H. Levy, Sabine Kurz, Margaret M. Tarpey, Koji Yamaguchi, Tetsuji Makita
Publikováno v:
Circulation. 99:53-59
Background —In a variety of disease states, endothelium-dependent vasodilation is abnormal. Reduced nitric oxide (NO) production, increased destruction of NO by superoxide, diminished cellular levels of l -arginine or tetrahydrobiopterin, and alter