Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Margaret M. O'Neill"'
Autor:
Margaret M. O’Neill, Ora Nakash
Publikováno v:
Journal of the Society for Social Work and Research. 12:803-829
Objective: Based on a single intake interview, mental health clinicians must distill their assessment to brief statements reflecting essential information. We explored how clinicians organi...
Autor:
Mohammed A. Kashem, Stanley Kugler, Lida Soleymanzadeh, Yunlong Zhang, Jeffery B. Madwed, Xin Guo, Kirrane Thomas M, Roger J. Snow, Alan David Swinamer, Jennifer Burke, Margaret M. O’Neill, Stephen J. Boyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:738-742
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of c
Autor:
Zhaoming Xiong, Stephen J. Boyer, Lida Soleymanzadeh, Stanley Kugler, John Westbrook, Yunlong Zhang, Anil Kumar Padyana, Jennifer Burke, Jeffrey B. Madwed, Derek Cogan, Alan David Swinamer, Chris Sarko, Mohammed A. Kashem, Frank M. DiCapua, Kirrane Thomas M, Amy Gao, Roger J. Snow, Xin Guo, Margaret M. O’Neill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:733-737
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were identified through high throughput screening. An RSK crystal structure and exploratory SAR
Autor:
Xi Shi, Paul S. Brookes, Bradford C. Berk, Chen Yan, Margaret M. O’Neill, Scott M. MacDonnell
Publikováno v:
Journal of cardiovascular pharmacology and therapeutics. 21(2)
Aims: During ischemia/reperfusion (I/R), ribosomal S6 kinase (RSK) activates Na+/H+ exchanger 1 (NHE1) by phosphorylating NHE1 at serine 703 (pS703-NHE1), which promotes cardiomyocyte death and injury. Pharmacologic inhibition of NHE1 effectively pro
Publikováno v:
APOPTOSIS. 6:151-160
In the present investigations, we have shown differential cleavage of cellular PARP and a caspase 3-selective synthetic tetrapeptide substrate, Z-DEVD-AFC or Ac-DEVD-AMC using a T lymphoblastoid cell line Jurkat, and its variant clone E6.1(J-E6). Ant
Autor:
Akalushi Muthukumarana, Frank M. DiCapua, Stanley Kugler, Fariba Soleymanzadeh, Glenn A. Reinhart, Rong Rhonda Chen, Margaret M. O’Neill, Jennifer Burke, Ryan M. Fryer, Roger J. Snow, Suzanne Nodop Mazurek, Jeffrey B. Madwed, Kirrane Thomas M, Roger M. Dinallo, Paul C. Harrison, Mohammed A. Kashem, Stephen J. Boyer, James D. Smith, Yunlong Zhang, Kyle E. Harrington, Xin Guo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 340(3)
We previously reported the discovery of a novel ribosomal S6 kinase 2 (RSK2) inhibitor, (R)-5-Methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a] indole-8-carboxylic acid [1-(3-dimethylamino-propyl)-1H-benzoimidazol-2-yl]-amide (BIX 02565), with
Autor:
Virginia D. Reale, William R. A. Osborne, Richard D. Schneiderman, Margaret M. O’Neill, Kyung Yu, Kelli Ann D Monaco, Charles A. Kennedy, Revati J. Tatake, Jacob D. Runyan, Randall W. Barton
Publikováno v:
Life sciences. 81(17-18)
In this report we describe development and characterization of four human cell lines that are able to secrete insulin and C-peptide in response to higher concentrations of glucose. These cell lines have been developed by stably and constitutively exp
Publikováno v:
Gene therapy. 8(5)
Gene transfer to primary cells, especially to lymphoid cells, using a nonviral delivery system has been very challenging. In the present studies, we have used a cationic polymer, polyethylenimine (PEI) coupled to an anti-CD3 antibody for achieving re
Autor:
Margaret M. O’Neill
Publikováno v:
Dual Diagnosis ISBN: 9781489924230
Feelings of frustration, anger, incompetence, and powerlessness are common among mental health professionals who encounter and/or work with people who are dually diagnosed. Studies of the attitudes of mental health and addiction clinicians toward alc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4fbbadd648bfb66c1aaf23b1c5e4b8
https://doi.org/10.1007/978-1-4899-2421-6_7
https://doi.org/10.1007/978-1-4899-2421-6_7
Autor:
Margaret M. O’Neill
Publikováno v:
Dual Diagnosis ISBN: 9781489924230
Recent recognition of the high prevalence rates of dual diagnosis has heightened our awareness of the particular limitations of our separate mental health and addiction treatment systems. The coexistence of substance use and psychiatric disorders pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce1c23ea9ff0f456ae0caac3edc83470
https://doi.org/10.1007/978-1-4899-2421-6_14
https://doi.org/10.1007/978-1-4899-2421-6_14