Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation

Autor: Nicolas Locker, Jia Lu, Ian Goodfellow, James M. Burke, Philipp Klein, Glenys Lewis, Margaret M. Willcocks, Valentina Iadevaia, Roy Parker, Michèle Brocard, Belinda S. Hall, Alessia Ruggieri

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 1, p e1008250 (2020)

Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress granules to limit the use o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9da426160cadaec62b62d778aa549ea
https://www.repository.cam.ac.uk/handle/1810/300971

Distinct roles for the IIId2 sub-domain in pestivirus and picornavirus internal ribosome entry sites

Autor: Salmah Zaini, Bruno Sargueil, Johanne Hadsbjerg, Nathalie Ulryck, Graham J. Belsham, Delphine Allouche, Margaret M. Willcocks, Noemie Rajagopalan, Nana A. Davids, Ulrik Fahnøe, Nicolas Locker, Thomas Bruun Rasmussen, Nathalie Chamond, Lisa O. Roberts

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (22), pp.13016-13028. ⟨10.1093/nar/gkx991⟩
Willcocks, M M, Zaini, S, Chamond, N, Ulryck, N, Allouche, D, Rajagopalan, N, Davids, N A, Fahn E, U, Hadsbjerg, J, Rasmussen, T B, Roberts, L O, Sargueil, B, Belsham, G J & Locker, N 2017, ' Distinct roles for the IIId2 sub-domain in pestivirus and picornavirus internal ribosome entry sites ', Nucleic Acids Research, vol. 2017, gkx991 . https://doi.org/10.1093/nar/gkx991

Viral internal ribosomes entry site (IRES) elements coordinate the recruitment of the host translation machinery to direct the initiation of viral protein synthesis. Within hepatitis C virus (HCV)-like IRES elements, the sub-domain IIId(1) is crucial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa5590fc41463f7d84386c2d9b73c62
https://pubmed.ncbi.nlm.nih.gov/29069411

Cleavage of eukaryotic initiation factor eIF4G and inhibition of host-cell protein synthesis during feline calicivirus infection

Autor: Michael J. Carter, Lisa O. Roberts, Margaret M. Willcocks

Publikováno v: Journal of General Virology. 85:1125-1130

Caliciviruses are small, non-enveloped, positive-stranded RNA viruses that are pathogenic for both animals and man. Although their capsid structure and genomic organization are distinct from picornaviruses, they have similarities to these viruses in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b757ebb16558bfabfdc248adad963e8
https://doi.org/10.1099/vir.0.19564-0

Application of electronmicroscopy, enzyme immunoassay, and RT-PCR to monitor an outbreak of astrovirus type 1 in a paediatric bone marrow transplant unit

Autor: W.D. Cubitt, H. Holzel, Michael J. Carter, Douglas K. Mitchell, Margaret M. Willcocks

Publikováno v: Journal of Medical Virology. 57:313-321

During 1997, an extensive outbreak of astrovirus occurred in a unit where paediatric patients were being treated for leukaemias and inherited immune deficiency disorders. Prolonged shedding of virus for many months following infection was demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f1bbd4c92a18fe75745f563dd23d682
https://doi.org/10.1002/(sici)1096-9071(199903)57:3<313::aid-jmv16>3.0.co

Mamastrovirus

Autor: Neel K. Krishna, Michael J. Carter, Margaret M. Willcocks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecbf64dec6ad669d035f3e8692606742
https://doi.org/10.1007/978-0-387-95919-1_11