Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Margaret M Morris-Downes"'
Autor:
J.K. O'Neill, Bert A. 't Hart, Gareth Pryce, Margaret M. Morris-Downes, David Baker, Paul Smith, Nicole Heijmans, Elizabeth Arter, Sandra Amor
Publikováno v:
Journal of Neuroimmunology, 164(1-2), 76-84. Elsevier
Smith, P A, Morris-Downes, M, Heijmans, N, Pryce, G, Arter, E, O'Neill, J K, 't Hart, B, Baker, D & Amor, S 2005, ' Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice ', Journal of Neuroimmunology, vol. 164, no. 1-2, pp. 76-84 . https://doi.org/10.1016/j.jneuroim.2005.04.006
Smith, P A, Morris-Downes, M, Heijmans, N, Pryce, G, Arter, E, O'Neill, J K, 't Hart, B, Baker, D & Amor, S 2005, ' Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice ', Journal of Neuroimmunology, vol. 164, no. 1-2, pp. 76-84 . https://doi.org/10.1016/j.jneuroim.2005.04.006
Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e80a5fbbcd57a8bcbd5fc3c3a5409e
https://doi.org/10.1016/j.jneuroim.2005.04.006
https://doi.org/10.1016/j.jneuroim.2005.04.006
Publikováno v:
Molecular Therapy. 8:886-894
We have initiated studies to determine the feasibility of employing the Semliki Forest virus (SFV) expression system as a central nervous system (CNS) vector. We investigated the effects of infecting Balb/c mice intranasally (i.n.) with recombinant S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a108cb4b3a17faf4d57f6e7d429eb9
https://doi.org/10.1016/j.ymthe.2003.09.010
https://doi.org/10.1016/j.ymthe.2003.09.010
Autor:
David Baker, Sara J. Piddlesden, Margaret M. Morris-Downes, Danielle Pham-Dinh, Paul Smith, Jon Rundle, Nicole Heijmans, Sandra Amor
Publikováno v:
Journal of Neuroimmunology. 125:114-124
Neurological deficit in experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS) is probably a consequence of synergy between T and B cell responses to CNS antigens. During the demyelinating phase of chronic relapsing EAE in ABH mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb8260c3c4229c1a4ce926e017ce2c3
https://doi.org/10.1016/s0165-5728(02)00040-1
https://doi.org/10.1016/s0165-5728(02)00040-1
Autor:
Hugh W Reid, Gregory J. Atkins, Margaret M Morris-Downes, Brian J. Sheahan, Peter Liljeström, Marina N. Fleeton
Publikováno v:
Vaccine. 19:3877-3884
This study has examined the efficacy following intramuscular administration of a recombinant Semliki Forest virus (rSFV) vaccine, encoding the prME and NS1 proteins of louping ill virus (LIV), in sheep. Administration of rSFV-LIV vaccine resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349cfd88cd4fa817a2c8e9b8a4d066fa
https://doi.org/10.1016/s0264-410x(01)00126-8
https://doi.org/10.1016/s0264-410x(01)00126-8
Publikováno v:
Gene Therapy. 7:1477-1482
We have utilised cell cultures and growth of tumours in nude mice to assess further the potential of the Semliki Forest virus (SFV) vector as a cancer therapy agent. This vector is a transient RNA-based expression vector, and we have previously shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9215515adaeec5232f816b371f717f
https://doi.org/10.1038/sj.gt.3301263
https://doi.org/10.1038/sj.gt.3301263
Autor:
Kirsty McCormack, David Baker, Margaret M. Morris-Downes, Sandra Amor, Janahan Natkunarajah, Dinesh Sivaprasad
Publikováno v:
Journal of Neuroimmunology, 122(1-2), 20-33. Elsevier
Morris-Downes, M M, McCormack, K, Baker, D, Sivaprasad, D, Natkunarajah, J & Amor, S 2002, ' Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL mice ', Journal of Neuroimmunology, vol. 122, no. 1-2, pp. 20-33 .
Morris-Downes, M M, McCormack, K, Baker, D, Sivaprasad, D, Natkunarajah, J & Amor, S 2002, ' Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL mice ', Journal of Neuroimmunology, vol. 122, no. 1-2, pp. 20-33 .
Synthetic peptides of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) were screened for their ability to induce experimental allergic encephalomyelitis (EAE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f43b9e1bc8ee2cbdce6efe5feb363a
https://pubmed.ncbi.nlm.nih.gov/11777540
https://pubmed.ncbi.nlm.nih.gov/11777540
Autor:
Daniel Todd, Brian J. Sheahan, Gregory J. Atkins, Peter Liljeström, Kerry V Phenix, Joan Smyth, Dorothy A. Mooney, Margaret M Morris-Downes, Sissela Lileqvist
Publikováno v:
Karolinska Institutet
This study has examined the persistence, distribution and pathological changes following intramuscular administration of Semliki Forest virus (SFV) vaccine vectors in mice and chickens. Administration of recombinant SFV RNA particles showed persisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bc4db24725f30d74347f1182294ec0
https://pubmed.ncbi.nlm.nih.gov/11228368
https://pubmed.ncbi.nlm.nih.gov/11228368
Autor:
Sareen E. Galbraith, Margaret M Morris-Downes, Stephen McQuaid, Gregory J. Atkins, Sara Louise Cosby, S. Amor, Brian J. Sheahan
Publikováno v:
Atkins, G J, McQuaid, S, Morris-Downes, M M, Galbraith, S E, Amor, S, Cosby, S L & Sheahan, B J 2000, ' Transient virus infection and multiple sclerosis ', Reviews in Medical Virology, vol. 10, no. 5, pp. 291-303 .
Reviews in Medical Virology
Reviews in Medical Virology
Multiple sclerosis (MS) is a chronic, demyelinating disease of the CNS in which autoimmunity to myelin plays a role in pathogenesis. The epidemiology of MS indicates that it may be triggered by a virus infection before the age of adolescence, but att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d140880a8ce3086ee0bcbb0b74fe3f31
https://research.vumc.nl/en/publications/275e1897-6e4d-41d3-b967-f99ec91d1a9a
https://research.vumc.nl/en/publications/275e1897-6e4d-41d3-b967-f99ec91d1a9a
Publikováno v:
Journal of neuroimmunology. 106(1-2)
Migration of cells into the central nervous system (CNS) is a pivotal step in the pathogenesis of immune-mediated diseases such as multiple sclerosis (MS), experimental allergic encephalomyelitis (EAE) and virus-induced demyelinating diseases. Such m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926828a31cca9513314f93a2d0293163
https://pubmed.ncbi.nlm.nih.gov/10814783
https://pubmed.ncbi.nlm.nih.gov/10814783
Autor:
O'Dwyer J; Department of Chemical and Environmental Sciences, Microbiology Laboratory, Centre for Environmental Research, University of Limerick, Limerick, Ireland E-mail: Jean.ODwyer@ul.ie., Morris Downes M; Department of Public Health, HSE-Midwest, Mount Kennett House, Mount Kennett Place, Henry Street, Limerick, Ireland., Adley CC; Department of Chemical and Environmental Sciences, Microbiology Laboratory, Centre for Environmental Research, University of Limerick, Limerick, Ireland E-mail: Jean.ODwyer@ul.ie.
Publikováno v:
Journal of water and health [J Water Health] 2016 Feb; Vol. 14 (1), pp. 39-46.