Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Margaret Lamble Mauchline"'
Publikováno v:
Vaccine. 19:288-297
A synthetic gene encoding the Hc (binding) domain of Clostridium botulinum neurotoxin F (FHc) was expressed in Escherichia coli fused to maltose binding protein (MBP). The purified MBP–FHc and FHc isolated after removal of MBP were evaluated in mic
Autor:
Mary E. Fox, John K. Brehm, Margaret Lamble Mauchline, Nigel P. Minton, J. Martin Brown, N. Paul Michael, Marylin J Lemmon, Amato J. Giaccia
Publikováno v:
FEMS Microbiology Reviews. 17:357-364
The toxicity associated with conventional cancer chemotherapy is primarily due to a lack of specificity for tumour cells. In contrast, intravenously injected clostridial spores exhibit a remarkable specificity for tumours. This is because, following
Autor:
P van Zijl, Mary E. Fox, Margaret Lamble Mauchline, Amato J. Giaccia, Marilyn J. Lemmon, Nigel P. Minton, Janice M. Brown
Publikováno v:
Gene therapy. 4(8)
A fundamental obstacle in gene therapy for cancer treatment is the specific delivery of an anticancer gene product to a solid tumor. Although several strategies exist to control gene expression once a vector is directly introduced into a tumor, as ye