Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Margaret Lai"'
Autor:
Wen-Jung Lu, Pang-Hung Hsu, Chun-Ju Chang, Cheng-Kuan Su, Yan-Jyun Huang, Hsuan-Ju Lin, Margaret Lai, Gui-Xia Ooi, Jing-Yi Dai, Hong-Ting Victor Lin
Publikováno v:
Antibiotics, Vol 10, Iss 11, p 1378 (2021)
Drug efflux pumps are one of the major elements used by antibiotic-resistant bacteria. Efflux pump inhibitors (EPIs) are potential therapeutic agents for adjunctive therapy, which can restore the activity of antibiotics that are no longer effective a
Externí odkaz:
https://doaj.org/article/8cb407740c8245b9bae60db66a861784
Autor:
Wen-Jung Lu, Ya-Chin Tsui, Chun-Ju Chang, Pang-Hung Hsu, Mei-Ying Huang, Margaret Lai, Yu-Wei Lian, Chia-Lin Chen, Hong-Ting Victor Lin
Publikováno v:
ACS Omega. 7:46486-46493
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::736ce6ce60adf53180662817a184121e
https://doi.org/10.1021/acsomega.2c05288
https://doi.org/10.1021/acsomega.2c05288
Autor:
Jing-Yi Dai, Pang-Hung Hsu, Wen-Jung Lu, Gui-Xia Ooi, Hong-Ting Victor Lin, Margaret Lai, Yan-Jyun Huang, Chun-Ju Chang, Hsuan-Ju Lin, Cheng-Kuan Su
Publikováno v:
Antibiotics, Vol 10, Iss 1378, p 1378 (2021)
Antibiotics
Volume 10
Issue 11
Antibiotics
Volume 10
Issue 11
Drug efflux pumps are one of the major elements used by antibiotic-resistant bacteria. Efflux pump inhibitors (EPIs) are potential therapeutic agents for adjunctive therapy, which can restore the activity of antibiotics that are no longer effective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a9b6f1734035748630083317da681f
https://www.mdpi.com/2079-6382/10/11/1378
https://www.mdpi.com/2079-6382/10/11/1378
Brown and Red Seaweeds Serve as Potential Efflux Pump Inhibitors for Drug-Resistant Escherichia coli
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2019 (2019)
Multidrug-resistant pathogens are a significant clinical problem. Efflux pump inhibitors (EPIs) can restore the activities of existing antibiotics by interfering with drug efflux pumps located in bacterial cell membranes. Seaweeds are important sourc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453b561b4704e1455504e3b218357981
Autor:
Wen-Jung, Lu, Hsuan-Ju, Lin, Pang-Hung, Hsu, Margaret, Lai, Jen-Yu, Chiu, Hong-Ting Victor, Lin
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Multidrug-resistant pathogens are a significant clinical problem. Efflux pump inhibitors (EPIs) can restore the activities of existing antibiotics by interfering with drug efflux pumps located in bacterial cell membranes. Seaweeds are important sourc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cec54203d6690d0556283ed04ea1a855
https://pubmed.ncbi.nlm.nih.gov/30713568
https://pubmed.ncbi.nlm.nih.gov/30713568
Autor:
Deborah L. Smith, Lee E. Schechter, Michael Z. Kagan, Nicole T. Hatzenbuhler, Amedeo Arturo Failli, Deborah Ann Evrard, Zhang Minsheng, Jeannette Golembieski, Richard Eric Mewshaw, Margaret Lai, Steven Edward Lenicek, Michael Chlenov, Jean Sze, Terrance H. Andree, Dahui Zhou, Annmarie L. Saab, Geoffrey Hornby, Reinhardt Bernhard Baudy, Boyd L. Harrison, Uresh Shantilal Shah, Kelly Sullivan
Publikováno v:
Journal of Medicinal Chemistry. 51:6980-7004
Novel compounds combining a 5-HT 1A moiety (3-aminochroman scaffold) and a 5-HT transporter (indole analogues) linked through a common basic nitrogen via an alkyl chain attached at the 1- or 3-position of the indole were evaluated for dual affinity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0888e59808afb3d9088f68290cf3d60e
https://doi.org/10.1021/jm8007097
https://doi.org/10.1021/jm8007097
Autor:
Steven M. Grauer, Peter J. Atkinson, Michael A. Olsen, Cody Kelley, Deborah L. Smith, Margaret Lai, Guoming Zhang, Feng Liu, Sharon Rosenzweig-Lipson, Chad E. Beyer, Michael Popiolek, Adam M. Gilbert, Mark Day, Karen L. Marquis, Radka Graf, Rachel Navarra, Claudine Pulicicchio, Farhana Pruthi, Xavier Z. Khawaja, Evguenia Kouranova, Sheree F. Logue, Tom A. Comery, Caitlin Wantuch, Mark H. Pausch, Nicholas J. Brandon
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 327:827-839
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) enhance N-methyl-d-aspartate receptor function and may represent a novel approach for the treatment of schizophrenia. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7619d349d85d8c5594fdd5c791082951
https://doi.org/10.1124/jpet.108.136580
https://doi.org/10.1124/jpet.108.136580
Publikováno v:
Molecular Brain Research. 135:276-279
Mineralocorticoid receptor expression is increased following neuronal injury, and this is associated with increased neuronal survival. Here we demonstrate a causal link between overexpression of MR in PC12 cells and protection against death induced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c9688ef04331f8262d18129d176ed1
https://doi.org/10.1016/j.molbrainres.2004.11.008
https://doi.org/10.1016/j.molbrainres.2004.11.008
Autor:
Jean Zhang, Ping Zhou, Tikva Carrick, Albert J. Robichaud, Rolf Feenstra, Jan-Hendrik Reinders, Dianne Kowal, Chris G. Kruse, Martina A.W. van der Neut, Yinfa Yan, David P. Rotella, Mark H. Pausch, Margaret Lai, Karen L. Marquis
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(9)
A dihydroquinolinone moiety was found to be a potent serotonin reuptake inhibitor pharmacophore when combined with certain amines. This fragment was coupled with selected D2 ligands to prepare a series of dual acting compounds with attractive in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5166982a958128acf3a0153c1b0e0b45
https://pubmed.ncbi.nlm.nih.gov/20347298
https://pubmed.ncbi.nlm.nih.gov/20347298
Autor:
Sharon Rosenzweig-Lipson, Deborah L. Smith, Feenstra Roelof W, Steven M. Grauer, Pierre Broqua, Rachel Navarra, David P. Rotella, Mark H. Pausch, Karen L. Marquis, Radka Graf, Albert J. Robichaud, Martina Van De Neut, Qian Lin, Claudine Pulicicchio, Farhana Pruthi, Wouter Goutier, Chad E. Beyer, Caitlin Wantuch, Julie A. Brennan, Zoë A. Hughes, Andrew C. McCreary, Margaret Lai, Chris G. Kruse
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 332(1)
The preclinical characterization of WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one] is described. In vitro binding and functional studies revealed highest affinity to the D(2) receptor (D(2L) K(i), 4.0 nM) and seroto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7b9cd3292b351096e029c21f167643
https://pubmed.ncbi.nlm.nih.gov/19828876
https://pubmed.ncbi.nlm.nih.gov/19828876