Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Margaret L. Van Keuren"'
Autor:
Jessica A Lehoczky, Peedikayil E Thomas, Kevin M Patrie, Kailey M Owens, Lisa M Villarreal, Kenneth Galbraith, Joe Washburn, Craig N Johnson, Bryant Gavino, Alexander D Borowsky, Kathleen J Millen, Paul Wakenight, William Law, Margaret L Van Keuren, Galina Gavrilina, Elizabeth D Hughes, Thomas L Saunders, Lesil Brihn, Joseph H Nadeau, Jeffrey W Innis
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003967 (2013)
Mouse early transposon insertions are responsible for ~10% of spontaneous mutant phenotypes. We previously reported the phenotypes and genetic mapping of Polypodia, (Ppd), a spontaneous, X-linked dominant mutation with profound effects on body plan m
Externí odkaz:
https://doaj.org/article/7e2168f239154d7b8e91247117543900
Autor:
Elizabeth D. Hughes, Sally A. Camper, Igor O. Nasonkin, Christopher D. Pacheco, Andrew P. Lieberman, Linda C. Samuelson, Margaret L. Van Keuren, Thomas L. Saunders, Suzanne J. Genik, Yun Yan Qu, Robert H. Lyons
Publikováno v:
Mammalian Genome. 18:549-558
Genetically modified mouse strains derived from embryonic stem (ES) cells are powerful tools for gene function analysis. ES cells from the C57BL/6 mouse strain are not widely used to generate mouse models despite the advantage of a defined genetic ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53144e3e83c11f10824f4e3d0a9dc771
https://doi.org/10.1007/s00335-007-9054-0
https://doi.org/10.1007/s00335-007-9054-0
Autor:
Thomas L. Saunders, Ellen G. Duysen, Andreea Ticu Boeck, Oksana Lockridge, Yuxia Wang, Margaret L. Van Keuren
Publikováno v:
Toxicology and Applied Pharmacology. 196:356-366
Organophosphorus toxicants (OP) include chemical nerve agents and pesticides. The goal of this work was to find out whether an animal could be made resistant to OP toxicity by genetic engineering. The human butyrylcholinesterase (BChE) mutant G117H w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1830ca56ba875a936d943f16dfadb40c
https://doi.org/10.1016/j.taap.2003.12.018
https://doi.org/10.1016/j.taap.2003.12.018
Autor:
Teresa Fernandes-Alnemri, Weizhen Ji, György Hajnóczky, Margaret L. Van Keuren, Thomas L. Saunders, Emad S. Alnemri, Miriam H. Meisler, Pinaki Datta, Zhi Jia Zhang, Sanjeev Gupta, Srinivasa M. Srinivasula, Julie M. Jones, Erika Davies
Publikováno v:
Nature. 425:721-727
The mouse mutant mnd2 (motor neuron degeneration 2) exhibits muscle wasting, neurodegeneration, involution of the spleen and thymus, and death by 40 days of age. Degeneration of striatal neurons, with astrogliosis and microglia activation, begins at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f420ec4e5cdc3ca5bb94708a926276af
https://doi.org/10.1038/nature02052
https://doi.org/10.1038/nature02052
Autor:
C. Clare Blackburn, Chun Hui Tsai, Eric Crombez, Richard Im, Pei Wen Chiang, Jason Greenfield, Saravanan Ramamoorthy, Su Qing Wang, David M. Kurnit, Margaret L. Van Keuren, Adnan Akhtar, Woo Joo Song, Paul Smithivas
Publikováno v:
Genomics. 34:368-375
To study gene regulation mediated by chromatin in mammals, we isolated the human (SUPT4H) and murine (Supt4h) counterparts of the yeast gene encoding SPT4; the product of this gene presumably interacts with the products of the mammalian homologues (w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e62f768fdaf24bde64cec231704b3a
https://doi.org/10.1006/geno.1996.0299
https://doi.org/10.1006/geno.1996.0299
Publikováno v:
Springer Protocols Handbooks ISBN: 9783642207914
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29342984f3954bbb8866d86ce30a0086
https://doi.org/10.1007/978-3-662-45763-4_9
https://doi.org/10.1007/978-3-662-45763-4_9
Autor:
Bonnie B. Blomberg, Marcia L. Budarf, Margaret L. Van Keuren, Thomas R. Bauer, Heather E. McDermid
Publikováno v:
Immunogenetics. 38:387-399
The human immunoglobulin lambda-like (IGLL) genes, which are homologous to the human immunoglobulin lambda (IGL) light chain genes, are expressed only in pre-B cells and are involved in B cell development. Three IGLL genes, 14.1, 16.1, and 16.2 are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2b503ec51c87e1ffe3460f6a97d9fb
https://doi.org/10.1007/bf00184519
https://doi.org/10.1007/bf00184519
Autor:
Galina B. Gavrilina, Margaret L. Van Keuren, Thomas L. Saunders, Wanda E. Filipiak, Michael G. Zeidler
Publikováno v:
Transgenic research. 18(5)
Transgenic mice are widely used in biomedical research to study gene expression, developmental biology, and gene therapy models. Bacterial artificial chromosome (BAC) transgenes direct gene expression at physiological levels with the same development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df2af9037684ebf2e6971b17ddef86f
https://pubmed.ncbi.nlm.nih.gov/19396621
https://pubmed.ncbi.nlm.nih.gov/19396621
Publikováno v:
Molecular Reproduction and Development. 29:129-135
Two-dimensional electrophoretograms were prepared from wild-type C57BL/6J embryos from day 7.5 through day 9.0 of development. This time period encompasses a critical window of development as the embryo traverses from an egg cylinder through major or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c46bfe4a01b9f2c136dd73b7d03e850
https://doi.org/10.1002/mrd.1080290207
https://doi.org/10.1002/mrd.1080290207
Autor:
William D. Law, Paul Wakenight, Alexander D. Borowsky, Margaret L. Van Keuren, Jessica A. Lehoczky, Joseph H. Nadeau, Elizabeth D. Hughes, Kailey M. Owens, Lisa M. Villarreal, Bryant J. Gavino, Galina B. Gavrilina, Jeffrey W. Innis, Peedikayil E. Thomas, Lesil E Brihn, Kenneth Galbraith, Craig N. Johnson, Thomas L. Saunders, Kathleen J. Millen, Joe Washburn, Kevin M. Patrie
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003967 (2013)
PLoS Genetics
PLoS Genetics
Mouse early transposon insertions are responsible for ∼10% of spontaneous mutant phenotypes. We previously reported the phenotypes and genetic mapping of Polypodia, (Ppd), a spontaneous, X-linked dominant mutation with profound effects on body plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb507c2fd075b532a12c4889324b6cd
https://doi.org/10.1371/journal.pgen.1003967
https://doi.org/10.1371/journal.pgen.1003967