Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Margaret L. Guthrie"'
Autor:
Leggy A. Arnold, Nicolas M Zahn, James M. Cook, Daniel A. Webb, Brandon N Mikulsky, Yeunus Mian, Margaret L. Guthrie, M S Rashid Roni, Douglas C. Stafford, Daniel E. Knutson
Publikováno v:
Curr Drug Metab
Background: MIDD0301 is an oral asthma drug candidate that binds GABAA receptors on airway smooth muscle and immune cells. Objective: The objective of this study is to identify and quantify MIDD0301 metabolites in vitro and in vivo and determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c0d7903e68b430c287bff185b5798d
https://doi.org/10.2174/1389200222666211202093841
https://doi.org/10.2174/1389200222666211202093841
Autor:
Gloria S. Forkuo, James M. Cook, Gene T. Yocum, Revathi Kodali, Leggy A. Arnold, Rajwana Jahan, Michael Rajesh Stephen, Margaret L. Guthrie, Douglas A. Steeber, Charles W. Emala, Douglas C. Stafford, Olivia B. Yu, Guanguan Li, Nicolas M Zahn, Ted William Harris, Janet L. Fisher, Amanda N. Nieman, M S Rashid Roni
Publikováno v:
Molecular Pharmaceutics. 15:1766-1777
We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α(5)β(3)γ(2) selective GABA(A) receptor (GABA(A)R) ligands. MIDD0301 relaxed airway smooth muscle at single micromolar concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b93345b08045b2b3af1122f8fda4a35
https://doi.org/10.1021/acs.molpharmaceut.7b01013
https://doi.org/10.1021/acs.molpharmaceut.7b01013
Autor:
Michael M. Poe, James M. Cook, Douglas C. Stafford, Leggy A. Arnold, Amanda N. Nieman, Nicolas M Zahn, Michael Rajesh Stephen, Ted William Harris, Guanguan Li, Revathi Kodali, Gene T. Yocum, Rajwana Jahan, Charles W. Emala, Benjamin D. Hartzler, Olivia B. Yu, Margaret L. Guthrie, Nina Y. Yuan, Douglas A. Steeber, Gloria S. Forkuo
Publikováno v:
Molecular Pharmaceutics. 14:2088-2098
We describe pharmacokinetic and pharmacodynamic properties of two novel oral drug candidates for asthma. Phenolic α4β3γ2 GABAAR selective compound 1 and acidic α5β3γ2 selective GABAAR positive allosteric modulator compound 2 relaxed airway smoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5755a9d9e97f0233975c5000c7783d33
https://doi.org/10.1021/acs.molpharmaceut.7b00183
https://doi.org/10.1021/acs.molpharmaceut.7b00183
Autor:
Amanda M. Barkley-Levenson, Marcia J. Ramaker, Leggy A. Arnold, Margaret L. Guthrie, Katherine M.J. McMurray, Abraham A. Palmer, M K Reddy, James M. Cook, Viresh H. Rawal, Preetpal S. Sidhu, P K Elkin, Stephanie C. Dulawa
Publikováno v:
Molecular psychiatry
Current pharmacotherapies for depression exhibit slow onset, side effects and limited efficacy. Therefore, identification of novel fast-onset antidepressants is desirable. GLO1 is a ubiquitous cellular enzyme responsible for the detoxification of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890a48e0787e174f34bde6b45fc3faec
https://doi.org/10.1038/mp.2017.14
https://doi.org/10.1038/mp.2017.14
Autor:
Margaret L. Guthrie, Nicolas M Zahn, Douglas C. Stafford, Rajwana Jahan, Leggy A. Arnold, James M. Cook, Charles W. Emala, Revathi Kodali, Olivia B. Yu, Nina Y. Yuan, Guanguan Li, Michael Rajesh Stephen, Gloria S. Forkuo, Gene T. Yocum, Michael M. Poe, Amanda N. Nieman
Publikováno v:
European Journal of Medicinal Chemistry. 126:550-560
We describe the synthesis of analogs of XHE-III-74, a selective α4β3γ2 GABAAR ligand, shown to relax airway smooth muscle ex vivo and reduce airway hyperresponsiveness in a murine asthma model. To improve properties of this compound as an asthma t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958734587f761ff39658058590c3aeda
https://doi.org/10.1016/j.ejmech.2016.11.045
https://doi.org/10.1016/j.ejmech.2016.11.045
Autor:
Michael M. Poe, Revathi Kodali, Gene T. Yocum, Margaret L. Guthrie, Marco Treven, Charles W. Emala, Benjamin D. Hartzler, Rajwana Jahan, Olivia B. Yu, Leggy A. Arnold, Guanguan Li, Michael Rajesh Stephen, James M. Cook, Nina Y. Yuan, Douglas C. Stafford, Gloria S. Forkuo, Nicolas M Zahn, Amanda N. Nieman, Margot Ernst
Publikováno v:
Molecular Pharmaceutics. 13:2026-2038
Recent studies have demonstrated that subtype-selective GABAA receptor modulators are able to relax precontracted human airway smooth muscle ex vivo and reduce airway hyper-responsiveness in mice upon aerosol administration. Our goal in this study wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cbadcb7c8bc5474f1d60762fc0c8f7
https://doi.org/10.1021/acs.molpharmaceut.6b00159
https://doi.org/10.1021/acs.molpharmaceut.6b00159
Autor:
Gloria S. Forkuo, Amanda N. Nieman, Revathi Kodali, Nicolas M. Zahn, Guanguan Li, M. S. Rashid Roni, Michael Rajesh Stephen, Ted W. Harris, Rajwana Jahan, Margaret L. Guthrie, Olivia B. Yu, Janet L. Fisher, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook, Leggy A. Arnold
Publikováno v:
Molecular Pharmaceutics. 16:4756-4756
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c76d467dd07547ff70186ecda308253
https://doi.org/10.1021/acs.molpharmaceut.9b01053
https://doi.org/10.1021/acs.molpharmaceut.9b01053
Autor:
Gloria S. Forkuo, Charles W. Emala, Gene T. Yocum, Oliva Yu, Mitchell H. Grayson, Margaret L. Guthrie, Douglas C. Stafford, Revathi Kodali, Amanda N. Nieman, Michael Rajesh Stephen, Leggy A. Arnold, James M. Cook
Publikováno v:
Journal of Allergy and Clinical Immunology. 141:AB81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d47651b2da19a58f496e40489afe89
https://doi.org/10.1016/j.jaci.2017.12.261
https://doi.org/10.1016/j.jaci.2017.12.261
Autor:
Rajwana Jahan, Revathi Kodali, Mitchell H. Grayson, Charles W. Emala, Olivia B. Yu, Gloria S. Forkuo, Gene T. Yocum, Margaret L. Guthrie, Michael S. Stephen, Amanda N. Nieman, Nina Yuan, Leggy A. Arnold, James M. Cook
Publikováno v:
Journal of Allergy and Clinical Immunology. 139:AB9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5fc7ef50e10cea776ec6fb1726f71d
https://doi.org/10.1016/j.jaci.2016.12.083
https://doi.org/10.1016/j.jaci.2016.12.083
Publikováno v:
Journal of chromatography. A. 1400
The separation of nine N,N′-dialkylimidazolium-based ionic liquids (ILs) by an isocratic hydrophilic interaction high-performance liquid chromatographic method using an unmodified silica column was investigated. The chosen analytical conditions usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35383ef30b59ef543f38d8f09ee447a
https://pubmed.ncbi.nlm.nih.gov/25979537
https://pubmed.ncbi.nlm.nih.gov/25979537