Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Margaret L, Hibbs"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Systemic lupus erythematosus (SLE, lupus) is a debilitating, multisystem autoimmune disease that can affect any organ in the body. The disease is characterized by circulating autoantibodies that accumulate in organs and tissues, which triggers an inf
Externí odkaz:
https://doaj.org/article/5d939bba29204a73b1b7949b58f3198e
Autor:
Erskine Chu, Richelle Mychasiuk, Tabitha R. F. Green, Akram Zamani, Larissa K. Dill, Rishabh Sharma, April L. Raftery, Evelyn Tsantikos, Margaret L. Hibbs, Bridgette D. Semple
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionSevere traumatic brain injury (TBI) is the world’s leading cause of permanent neurological disability in children. TBI-induced neurological deficits may be driven by neuroinflammation post-injury. Abnormal activity of SH2 domain-contain
Externí odkaz:
https://doaj.org/article/0202688fd3b94e7cb9056756e32b300f
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis are chronic relapsing diseases that affect the gastrointestinal tract, most commonly the colon. A link between the gut and the lung is suggested since patients with IB
Externí odkaz:
https://doaj.org/article/ea871909095342a590d031e427935852
Autor:
Jack Polmear, Lauren Hailes, Moshe Olshansky, Maureen Rischmueller, Elan L'Estrange‐Stranieri, Anne L Fletcher, Margaret L Hibbs, Vanessa L Bryant, Kim L Good‐Jacobson
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 10, Pp n/a-n/a (2023)
Abstract Objectives B cells drive the production of autoreactive antibody‐secreting cells (ASCs) in autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Sjögren's syndrome, causing long‐term organ damage. Current treatments for ant
Externí odkaz:
https://doaj.org/article/a2cc8dc41eea467d987f4c8b9f2b2986
Autor:
Erskine Chu, Richelle Mychasiuk, Evelyn Tsantikos, April L. Raftery, Elan L’Estrange-Stranieri, Larissa K. Dill, Bridgette D. Semple, Margaret L. Hibbs
Publikováno v:
Cells, Vol 12, Iss 19, p 2378 (2023)
Chronic neuroinflammation and glial activation are associated with the development of many neurodegenerative diseases and neuropsychological disorders. Recent evidence suggests that the protein tyrosine kinase Lyn and the lipid phosphatase SH2 domain
Externí odkaz:
https://doaj.org/article/29ffbe758fc14068bb2d71111ba467ac
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Microglia are integral mediators of innate immunity within the mammalian central nervous system. Typical microglial responses are transient, intending to restore homeostasis by orchestrating the removal of pathogens and debris and the regene
Externí odkaz:
https://doaj.org/article/66e416b4e60b47ce875018a43baf08b7
Publikováno v:
Immunity, Inflammation and Disease, Vol 9, Iss 3, Pp 758-770 (2021)
Abstract Systemic lupus erythematosus (lupus) is an autoimmune disease characterized by autoantibodies that form immune complexes with self‐antigens, which deposit in various tissues, leading to inflammation and disease. The etiology of disease is
Externí odkaz:
https://doaj.org/article/4fc8bab9e431498f8c54b235ab022d0e
Autor:
Timothy A. Gottschalk, Pamela Hall, Evelyn Tsantikos, Elan L’Estrange-Stranieri, Michael J. Hickey, Margaret L. Hibbs
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Systemic lupus erythematosus (SLE) is a complex, heterogeneous autoimmune disease. A common manifestation, lupus nephritis, arises from immune complex deposition in the kidney microvasculature promoting leukocyte activation and infiltration, which tr
Externí odkaz:
https://doaj.org/article/7107fb7966754792a47ff847410cab90
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The lung is a vital mucosal organ that is constantly exposed to the external environment, and as such, its defenses are continuously under threat. The pulmonary immune system has evolved to sense and respond to these danger signals while remaining si
Externí odkaz:
https://doaj.org/article/0ff5f2724f34474e90bfeb110074d1df
Autor:
Moritz F. Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R. Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D. Huntington, Margaret L. Hibbs, Alex Boussioutas, Michele A. Grimbaldeston, Michael Buchert, Robert J. J. O’Donoghue, Frederick Masson, Matthias Ernst
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumor
Externí odkaz:
https://doaj.org/article/358dfe59c0ac41659d29059d99a2f0be