Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Margaret K Seeley-Fallen"'
Publikováno v:
eLife, Vol 12 (2023)
Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering cell-surface antigens, actin-driven B-cell spreading amplifi
Externí odkaz:
https://doaj.org/article/e4b2c0ae34a5410b8a168f0863cce1c7
Autor:
Margaret K. Seeley-Fallen, Michelle Lazzaro, Chaohong Liu, Quan-Zhen Li, Arpita Upadhyaya, Wenxia Song
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antigen (Ag)-triggered B-cell receptor (BCR) signaling initiates antibody responses. However, prolonged or uncontrolled BCR signaling is associated with the development of self-reactive B-cells and autoimmune diseases. We previously showed that actin
Externí odkaz:
https://doaj.org/article/cc57427a9ba4416da2c48ff8e34e3eb3
Autor:
Arpita Upadhyaya, Wenxia Song, Margaret K. Seeley-Fallen, Christina Ketchum, Heather Miller, Chaohong Liu
Publikováno v:
Immunological Reviews. 256:177-189
Upon recognizing cognate antigen, B cells mobilize multiple cellular apparatuses to propagate an optimal response. Antigen binding is transduced into cytoplasmic signaling events through B-cell antigen receptor (BCR)-based signalosomes at the B-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65414d3dc545b4ef94305e073f387fe
https://doi.org/10.1111/imr.12113
https://doi.org/10.1111/imr.12113
Autor:
Lisa J. Liu, Margaret K. Seeley-Fallen, Olusegun O. Onabajo, Xiaoping Zhu, Wenxia Song, Arpita Upadhyaya, Tse-Hua Tan, Senthilkumar Palaniyandi, Melanie R. Shapiro
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(27)
Prolonged or uncontrolled B-cell receptor (BCR) signaling is associated with autoimmunity. We previously demonstrated a role for actin in BCR signal attenuation. This study reveals that actin-binding protein 1 (Abp1/HIP-55/SH3P7) is a negative regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d05612cded8123d7c554219de04c85
https://pubmed.ncbi.nlm.nih.gov/24958882
https://pubmed.ncbi.nlm.nih.gov/24958882