E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells

Autor: Ben Liu, Benjamin Parent, Sarah Mansour, Zsofia Sztupinszki, Haohui Duan, Andrew E. H. Elia, Judy Garber, Rachel Reed, Zoltan Szallasi, Nicolai Juul Birkbak, Shailja Pathania, Margaret K Gillis

Publikováno v: The Journal of Cell Biology
Duan, H, Mansour, S, Reed, R, Gillis, M K, Parent, B, Liu, B, Sztupinszki, Z, Birkbak, N, Szallasi, Z, Elia, A E H, Garber, J E & Pathania, S 2020, ' E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells ', The Journal of Cell Biology, vol. 219, no. 6, e201908192 . https://doi.org/10.1083/jcb.201908192

BRCA1/2 help maintain genomic integrity by stabilizing stalled forks for repair and thus act as tumor suppressors. Duan et al. identify the E3 ligase RFWD3 as a novel modulator of stalled fork stability in BRCA2-deficient cells and show that blocking

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https://doi.org/10.1083/jcb.201908192