Výsledky vyhledávání - "Margaret J. Stafford"

Bioinformatic and experimental survey of 14-3-3-binding sites

Autor: Carol MacKintosh, David G. Campbell, Sandra Crowther, Margaret J. Stafford, Rachel Toth, Catherine Johnson

Publikováno v: Biochemical Journal

More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3-3/phosphoprotein networks work. Mode I RXX(pS/pT)XP motifs d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233aa1db83f31d992236e3066a26f892
https://doi.org/10.1042/bj20091834

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Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of IκBα Kinase

Autor: Margaret J. Stafford, Philip Cohen, Mark Windheim, Mark Peggie

Publikováno v: Molecular and Cellular Biology. 28:1783-1791

Interleukin 1 (IL-1) has been reported to stimulate the polyubiquitination and disappearance of IL-1 receptor-associated kinase 1 (IRAK1) within minutes. It has been thought that the polyubiquitin chains attached to IRAK1 are linked via Lys48 of ubiq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665dcf8564ca4ccd71a9733948979c50
https://doi.org/10.1128/mcb.02380-06

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PKD: a new protein kinase C–dependent pathway in platelets

Autor: Margaret J. Stafford, Steve P. Watson, Catherine J. Pears

Publikováno v: Blood. 101:1392-1399

Protein kinase D (PKD, also known as PKCμ) is closely related to the protein kinase C superfamily but is differentially regulated and has a distinct catalytic domain that shares homology with Ca2+-dependent protein kinases. PKD is highly expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b97404b7bd125328ea3f98c0d31a97
https://doi.org/10.1182/blood-2002-08-2384

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Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin

Autor: Margaret J. Stafford, Catherine J. Pears, Ben T. Atkinson, Steve P. Watson

Publikováno v: European Journal of Biochemistry. 268:5242-5248

We have investigated the role of secretion and intracellular signalling events in aggregation induced by the glycoprotein (GP)VI-selective snake venom toxin convulxin and by collagen. We demonstrate that aggregation induced by threshold concentration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74259de8eb57c3c5267da8550cc3f097
https://doi.org/10.1046/j.0014-2956.2001.02448.x

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Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62

Autor: Mark Peggie, Nick A. Morrice, Philip Cohen, Margaret J. Stafford

Publikováno v: FEBS letters. 580(16)

The protein kinase COT/Tpl2 is activated by interleukin-1 (IL-1), TNFalpha and lipopolysaccharide, and its activation by these agonists involves the IkappaB kinase beta (IKKbeta) catalysed phosphorylation of the p105 regulatory subunit. Here, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84387308062a74b187f45c840b9a0c13
https://pubmed.ncbi.nlm.nih.gov/16806191

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Characterization of the reversible phosphorylation and activation of ERK8

Autor: Iva V. Klevernic, Margaret J. Stafford, Philip Cohen, Simon Morton, Nicholas A. Morrice, Mark Peggie

ERK8 (extracellular-signal-regulated protein kinase 8) expressed in Escherichia coli or insect cells was catalytically active and phosphorylated at both residues of the Thr-Glu-Tyr motif. Dephosphorylation of the threonine residue by PP2A (protein se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f76b8dd4aca4d27d70130f01e64a1e
https://europepmc.org/articles/PMC1386035/

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Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester

Autor: Steve P. Watson, Margaret J. Stafford, Ben T. Atkinson, Catherine J. Pears

Publikováno v: Platelets. 12(8)

Although it is well established that G(q)- and G(i)-coupled receptors can combine to mediate platelet aggregation, the signalling events underlying the synergy are not fully characterised. This study has used the calcium ionophore, A23187, and phorbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9395aa350fe25bd2b3e9838ae99ef9ea
http://ora.ox.ac.uk/objects/uuid:df30f04f-15f4-43f7-95d6-17b87667bae0

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The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Autor: Margaret J. Stafford, Jon Frampton, Daniel C. Snell, Regis Bobe, Oscar Berlanga, Ben T. Atkinson, Peter Wonerow, Steve P. Watson, Naoki Asazuma, Jonathan I. Wilde, Stuart J. Marshall, Gavin E. Jarvis, Denise Best, David Tulasne

Publikováno v: Europe PubMed Central
David Tulasne
Scopus-Elsevier

SummaryThe major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor γ-chain (FcR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b9e0a767569e408ff235b82b842547
https://pubmed.ncbi.nlm.nih.gov/11487016

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Dual-chamber cardiac pacemakers

Autor: Kristin M. Kleinschmidt, Margaret J. Stafford

Publikováno v: The Journal of cardiovascular nursing. 5(3)

Dual-chamber cardiac pacing provides distinct advantages over single-chamber systems, namely atrioventricular synchrony, improved cardiac output, and prevention of pacemaker syndrome. Providing nursing care to patients with dual-chamber pacemakers de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fae05f94c9b192d991e09766b12ac48
https://pubmed.ncbi.nlm.nih.gov/2010801

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