Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Margaret J. Currie"'
Autor:
Ben Topham, Millie de Vries, Maria Nonis, Rebecca van Berkel, Juliet M. Pullar, Nicholas J. Magon, Margreet C. M. Vissers, Margaret J. Currie, Bridget A. Robinson, David Gibbs, Abel Ang, Gabi U. Dachs
Publikováno v:
Epigenomes, Vol 8, Iss 2, p 17 (2024)
The treatment of metastatic melanoma has been revolutionised by immunotherapy, yet a significant number of patients do not respond, and many experience autoimmune adverse events. Associations have been reported between patient outcome and monocyte su
Externí odkaz:
https://doaj.org/article/f0a8556d4d2b4ffcbb4e8fb7b96cfc9d
Autor:
Emma K. C. Symonds, Bianca Black, Alexander Brown, Ineke Meredith, Margaret J. Currie, Kathryn E. Hally, Kirsty M. Danielson
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 8, Pp n/a-n/a (2023)
Abstract EVs released by adipose derived stem cells (ADSCs) have shown promise as a therapeutic for tissue repair because of their purported immune‐regulatory properties. Extracellular vesicles (EVs) from ADSCs could be beneficial in improving graf
Externí odkaz:
https://doaj.org/article/72f89b80254c4bcdb20a7348d4186cca
Autor:
Rebekah L. I. Crake, Matthew R. Strother, Elisabeth Phillips, Matthew P. Doogue, Mei Zhang, Chris M. A. Frampton, Bridget A. Robinson, Margaret J. Currie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Individual response to chemotherapy in patients with breast cancer is variable. Obesity and exercise are associated with better and worse outcomes, respectively, and it is known that both impact the systemic cytokine milieu. Cytochrome P450
Externí odkaz:
https://doaj.org/article/45a23ed6212a497b8c55e098cc90fea8
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Exercise is increasingly becoming a standard of cancer care, with well-documented benefits for patients including improved mental wellbeing and reduced treatment-related side effects. However, important gaps in knowledge remain about how to optimise
Externí odkaz:
https://doaj.org/article/95e1799d20054d97a95a862d431acc55
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 430 (2021)
Tumour-associated macrophages (TAMs) are ubiquitously present in tumours and commonly associated with poor prognosis. In immune cells, ascorbate affects epigenetic regulation, differentiation and phenotype via its co-factor activity for the 2-oxoglut
Externí odkaz:
https://doaj.org/article/198dd28567054dac9734b28ac02b5e5a
Autor:
Vanessa L. Lattimore, John F. Pearson, Margaret J. Currie, Amanda B. Spurdle, kConFab Investigators, Bridget A. Robinson, Logan C. Walker
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
PCR-based RNA splicing assays are commonly used in diagnostic and research settings to assess the potential effects of variants of uncertain clinical significance in BRCA1 and BRCA2. The Evidence-based Network for the Interpretation of Germline Mutan
Externí odkaz:
https://doaj.org/article/a1295ed0b5a6453589744f9f1328d10e
Autor:
Vanessa L. Lattimore, John F. Pearson, Arthur E. Morley-Bunker, kConFab Investigators, Amanda B. Spurdle, Bridget A. Robinson, Margaret J. Currie, Logan C. Walker
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 693 (2019)
BRCA1 and BRCA2 spliceogenic variants are often associated with an elevated risk of breast and ovarian cancers. Analyses of BRCA1 and BRCA2 splicing patterns have traditionally used technologies that sample a population of cells but do not account fo
Externí odkaz:
https://doaj.org/article/e2c531f6209d47d69d732f5052e40942
Autor:
Margreet C.M. Vissers, Peter H. Sykes, Margaret J. Currie, Gabi U. Dachs, Ilona G.M. Molenaar, Caroline Kuiper
Activation of the transcription factor hypoxia-inducible factor (HIF)-1 allows solid tumors to thrive under conditions of metabolic stress. Because HIF-1 is switched off by hydroxylation reactions that require ascorbate, inadequate intracellular asco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547d7bfda2a61c3b07d172176e274104
https://doi.org/10.1158/0008-5472.c.6500103.v1
https://doi.org/10.1158/0008-5472.c.6500103.v1
Autor:
Margreet C.M. Vissers, Peter H. Sykes, Margaret J. Currie, Gabi U. Dachs, Ilona G.M. Molenaar, Caroline Kuiper
Supplementary Table 2 from Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1449c595d1fb10022e380c1a159d6d79
https://doi.org/10.1158/0008-5472.22382106
https://doi.org/10.1158/0008-5472.22382106
Autor:
Margreet C.M. Vissers, Peter H. Sykes, Margaret J. Currie, Gabi U. Dachs, Ilona G.M. Molenaar, Caroline Kuiper
Supplementary Table 1 from Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19a94fa12683c372edc27ed9287f88f
https://doi.org/10.1158/0008-5472.22382109.v1
https://doi.org/10.1158/0008-5472.22382109.v1