Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Margaret J Mackinnon"'
Autor:
James Tuju, Margaret J Mackinnon, Abdirahman I Abdi, Henry Karanja, Jennifer N Musyoki, George M Warimwe, Evelyn N Gitau, Kevin Marsh, Peter C Bull, Britta C Urban
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007870 (2019)
Naturally acquired clinical immunity to Plasmodium falciparum is partly mediated by antibodies directed at parasite-derived antigens expressed on the surface of red blood cells which mediate disease and are extremely diverse. Unlike children, adults
Externí odkaz:
https://doaj.org/article/e1999a7e303249468f8d34266c07f1fa
Autor:
Margaret J Mackinnon, Jinguang Li, Sachel Mok, Moses M Kortok, Kevin Marsh, Peter R Preiser, Zbynek Bozdech
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000644 (2009)
Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted field isolates of Plasmodium falciparum, t
Externí odkaz:
https://doaj.org/article/b2eb6c66a76a401f8b13df914cc3be97
Publikováno v:
PLoS Medicine, Vol 2, Iss 12, p e340 (2005)
While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown.We have used pedigree-based genetic variance component analysis to determine the relative co
Externí odkaz:
https://doaj.org/article/287e1d2e0c7740e1b368164465893d0f
Autor:
Margaret J Mackinnon, Andrew F Read
Publikováno v:
PLoS Biology, Vol 2, Iss 9, p E230 (2004)
Evolutionary models predict that host immunity will shape the evolution of parasite virulence. While some assumptions of these models have been tested, the actual evolutionary outcome of immune selection on virulence has not. Using the mouse malaria
Externí odkaz:
https://doaj.org/article/f700949a023f4f47be457fd8b07aa412
Autor:
Gavin Band, Robert W. Snow, Carolyne M. Ndila, Alex Macharia, Sophie Uyoga, Kirk A. Rockett, Margaret J. Mackinnon, Dominic P. Kwiatkowski, Anna Rautanen, Thomas N. Williams
Publikováno v:
Molecular Biology and Evolution
Genome-wide searches for loci involved in human resistance to malaria are currently being conducted on a large scale in Africa using case-control studies. Here, we explore the utility of an alternative approach—“environmental correlation analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c628b32caab767187271781512cf1dc4
https://doi.org/10.1093/molbev/msw004
https://doi.org/10.1093/molbev/msw004
Autor:
Sachel Mok, Joyce M. Ngoi, Margaret J. Mackinnon, Joan Simam, Mary Nyonda, Zbynek Bozdech, Martin Rono, Kevin Marsh
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-15 (2018)
BMC Genomics
BMC Genomics
Background Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bb7f869a12c0417dc13deedda092ae
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
John N. Waitumbi, Abdullah Sayied Abdullah, Martin Rono, Moses Kortok, Mary Nyonda, Margaret J. Mackinnon, Zbynek Bozdech, Kevin Marsh, Mohammed M. Elfaki, Ibrahim M. Elhassan, Joan Simam, Sachel Mok, Joyce M. Ngoi
Publikováno v:
Nat Ecol Evol
Success in eliminating malaria will depend on whether parasite evolution outpaces control efforts. Here, we show that Plasmodium falciparum parasites (the deadliest of the species causing human malaria) found in low-transmission-intensity areas have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b24b712bd6b5d4de02733d1e54e586
https://ora.ox.ac.uk/objects/uuid:ccaa2ae1-40a4-4fc5-9fb0-b0cc44af4ffc
https://ora.ox.ac.uk/objects/uuid:ccaa2ae1-40a4-4fc5-9fb0-b0cc44af4ffc
Autor:
Kevin Marsh, Jennifer N. Musyoki, Margaret J. Mackinnon, Philip Bejon, Peter C. Bull, George M. Warimwe, Claire L. Mackintosh, Sam Kinyanjui
In studies of immunity to malaria, the absence of febrile malaria is commonly considered evidence of “protection.” However, apparent “protection” may be due to a lack of exposure to infective mosquito bites or due to immunity. We studied a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b42f2ec2d569bb1ae9320489570e151
https://ora.ox.ac.uk/objects/uuid:eea29dbe-9fc0-4f5f-b582-42ce91b8b9d2
https://ora.ox.ac.uk/objects/uuid:eea29dbe-9fc0-4f5f-b582-42ce91b8b9d2
Autor:
Steve A. Ward, Kevin Marsh, Leah Mwai, Philip Sasi, Edwin Ochong, Alexis Nzila, Steven M. Kiara, Gilbert Kokwaro, Margaret J. Mackinnon, Steffen Borrmann, Abdi Abdirahman
Publikováno v:
Malaria Journal, Vol 8, Iss 1, p 106 (2009)
Malaria Journal
Malaria Journal
Background The spread of resistance to chloroquine (CQ) led to its withdrawal from use in most countries in sub-Saharan Africa in the 1990s. In Malawi, this withdrawal was followed by a rapid reduction in the frequency of resistance to the point wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc77cecfc090aafed26abe16c15c421
https://ora.ox.ac.uk/objects/uuid:bce2c24c-5748-4ca3-a532-3f5de141516d
https://ora.ox.ac.uk/objects/uuid:bce2c24c-5748-4ca3-a532-3f5de141516d
Publikováno v:
Malaria Journal
BACKGROUND: A series of elegant experiments was recently published which demonstrated that transmission of malaria parasites through mosquitoes elicited an attenuated growth phenotype, whereby infections grew more slowly and reached peak parasitaemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89af4271b68e8485f20ac7943b0150c
https://ora.ox.ac.uk/objects/uuid:a2510190-9b86-4b60-8d86-d6bf8fde6397
https://ora.ox.ac.uk/objects/uuid:a2510190-9b86-4b60-8d86-d6bf8fde6397