Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Margaret J Dawson"'
Autor:
Harjeet Singh, Matthew J Figliola, Margaret J Dawson, Simon Olivares, Ling Zhang, Ge Yang, Sourindra Maiti, Pallavi Manuri, Vladimir Senyukov, Bipulendu Jena, Partow Kebriaei, Richard E Champlin, Helen Huls, Laurence J N Cooper
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64138 (2013)
Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) is being evaluated in multiple clinical trials. Our current approach to adoptive immunotherapy is based on a second generation CAR (designated CD19RCD28) that sig
Externí odkaz:
https://doaj.org/article/9e74176212bd40a58bea38aeed27eae3
Autor:
Laurence J.N. Cooper, Richard E. Champlin, Dean A. Lee, Partow Kebriaei, Sourindra Maiti, Tiejuan Mi, Kirsten Switzer, Simon Olivares, Helen Huls, Margaret J. Dawson, Matthew J. Figliola, Harjeet Singh
Supplementary Figure 1 from Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4076b52e651b57eeefa493e57eeb308
https://doi.org/10.1158/0008-5472.22388582
https://doi.org/10.1158/0008-5472.22388582
Autor:
Brian Rabinovich, Helen Huls, Sonny Ang, Denise L. Crossland, Laurence J.N. Cooper, Pullavathi Rao, Hiroki Torikai, Dean A. Lee, Margaret J. Dawson, Richard E. Champlin, Harjeet Singh, Matthew J. Figliola, Ling Zhang, Perry B. Hackett, Partow Kebriaei, Sourindra Maiti, Simon Olivares, Ge Yang, Yi Jue Zhao, Asha S. Multani
Publikováno v:
Journal of Immunotherapy. 36:112-123
The Sleeping Beauty (SB) transposon/transposase DNA plasmid system is used to genetically modify cells for long-term transgene expression. We adapted the SB system for human application and generated T cells expressing a chimeric antigen receptor (CA
Autor:
Simon Olivares, Tiejuan Mi, Partow Kebriaei, Sourindra Maiti, Matthew J. Figliola, Dean A. Lee, Richard E. Champlin, Margaret J. Dawson, Harjeet Singh, Laurence J.N. Cooper, Helen Huls, Kirsten Switzer
Publikováno v:
Cancer Research. 71:3516-3527
Improving the therapeutic efficacy of T cells expressing a chimeric antigen receptor (CAR) represents an important goal in efforts to control B-cell malignancies. Recently an intrinsic strategy has been developed to modify the CAR itself to improve T
Autor:
Pulivarthi H. Rao, Tiejuan Mi, Laurence J.N. Cooper, Pallavi R. Manuri, Joseph M. Kaminski, Richard E. Champlin, Harjeet Singh, Margaret J. Dawson, Stephen Gottschalk, Matthew H. Wilson, Helen Huls, Simon Olivares, Elizabeth J. Shpall, Yozo Nakazawa, Partow Kebriaei, Sourindra Maiti, Dean A. Lee
Publikováno v:
Human Gene Therapy. 21:427-437
Nonviral integrating vectors can be used for expression of therapeutic genes. piggyBac (PB), a transposon/transposase system, has been used to efficiently generate induced pluripotent stems cells from somatic cells, without genetic alteration. In thi
Autor:
Partow Kebriaei, Richard E. Champlin, Simon Olivares, Elizabeth J. Shpall, Laurence J.N. Cooper, Margaret J. Dawson, M. Helen Huls, Harjeet Singh, Matthew J. Figliola
Publikováno v:
Journal of Visualized Experiments.
The potency of clinical-grade T cells can be improved by combining gene therapy with immunotherapy to engineer a biologic product with the potential for superior (i) recognition of tumor-associated antigens (TAAs), (ii) persistence after infusion, (i
Autor:
Harjeet Singh, Margaret J. Dawson, Helen Huls, Donald B. Kohn, Elizabeth J. Shpall, Pallavi R. Manuri, Simon Olivares, Laurence J.N. Cooper, Richard E. Champlin, Perry B. Hackett, Navid Dara
Publikováno v:
Cancer research. 68(8)
Genetic modification of clinical-grade T cells is undertaken to augment function, including redirecting specificity for desired antigen. We and others have introduced a chimeric antigen receptor (CAR) to enable T cells to recognize lineage-specific t
Autor:
Harjeet Singh, Sourindra Maiti, Laurence J.N. Cooper, Richard E. Champlin, Margaret J. Dawson, Elizabeth J. Shpall, Matthew J. Figliola, S.S. Kelly
Publikováno v:
Biology of Blood and Marrow Transplantation. 16(2):S182-S183
Autor:
Richard E. Champlin, Pallavi R. Manuri, Laurence J.N. Cooper, Dean A. Lee, Elizabeth J. Shpall, Navid Dara, Simon Olivares, Helen Huls, Margaret J. Dawson
Publikováno v:
Biology of Blood and Marrow Transplantation. 14(2):13-14
Autor:
Richard E. Champlin, Bipulendu Jena, Pallavi R. Manuri, Laurence J.N. Cooper, Vladimir Senyukov, Partow Kebriaei, Sourindra Maiti, Margaret J. Dawson, Harjeet Singh, Matthew J. Figliola, Simon Olivares, Ge Yang, Helen Huls, Ling-ling Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64138 (2013)
PLoS ONE
PLoS ONE
Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) is being evaluated in multiple clinical trials. Our current approach to adoptive immunotherapy is based on a second generation CAR (designated CD19RCD28) that sig