Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Margaret Gatz"'
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Differences in gene-wide DNA methylation of the Alzheimer’s disease (AD)-associated genes BIN1, HLA-DRB5, SORL1, SLC24A4, and ABCA7 are reported to be associated with AD in post-mortem brain samples. We investigated whether the same associations co
Externí odkaz:
https://doaj.org/article/4315579fa2a54c28bb421ac5755d831c
Autor:
Jiahui Hou, Jonathan L. Hess, Nicola Armstrong, Joshua C. Bis, Benjamin Grenier-Boley, Ida K. Karlsson, Ganna Leonenko, Katya Numbers, Eleanor K. O’Brien, Alexey Shadrin, Anbupalam Thalamuthu, Qiong Yang, Ole A. Andreassen, Henry Brodaty, Margaret Gatz, Nicole A. Kochan, Jean-Charles Lambert, Simon M. Laws, Colin L. Masters, Karen A. Mather, Nancy L. Pedersen, Danielle Posthuma, Perminder S. Sachdev, Julie Williams, the Alzheimer’s Disease Neuroimaging Initiative, Chun Chieh Fan, Stephen V. Faraone, Christine Fennema-Notestine, Shu-Ju Lin, Valentina Escott-Price, Peter Holmans, Sudha Seshadri, Ming T. Tsuang, William S. Kremen, Stephen J. Glatt
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Polygenic risk scores (PRSs) can boost risk prediction in late-onset Alzheimer’s disease (LOAD) beyond apolipoprotein E (APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-confe
Externí odkaz:
https://doaj.org/article/05a0a605763842d88fd8cbd81b52d67b
Autor:
Karri Silventoinen, Maarit Piirtola, Aline Jelenkovic, Reijo Sund, Adam D. Tarnoki, David L. Tarnoki, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Margaret Gatz, David A. Butler, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Carol E. Franz, William S. Kremen, Michael J. Lyons, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Per Tynelius, Finn Rasmussen, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Jessica Tyler, John L. Hopper, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucia Colodro-Conde, Esther Rebato, Dongfeng Zhang, Zengchang Pang, Qihua Tan, Judy L. Silberg, Hermine H. Maes, Dorret I. Boomsma, Thorkild I. A. Sørensen, Tellervo Korhonen, Jaakko Kaprio
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic
Externí odkaz:
https://doaj.org/article/a04289e4c6684fb58b460af114fe9ff4
Autor:
Dominika Seblova, Chloe Eng, Justina F. Avila‐Rieger, Jordan D. Dworkin, Kelly Peters, Susan Lapham, Laura B. Zahodne, Benjamin Chapman, Carol A. Prescott, Tara L. Gruenewald, Thalida Em. Arpawong, Margaret Gatz, Rich J. Jones, Maria M. Glymour, Jennifer J. Manly
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract We leveraged a unique school‐based longitudinal cohort—the Project Talent Aging Study—to examine whether attending higher quality schools is associated with cognitive performance among older adults in the United States (mean age = 74.8
Externí odkaz:
https://doaj.org/article/91e1de8e865647d8befc598768c6f8b8
Autor:
Ying Liu, Stefan Schneider, Bart Orriens, Erik Meijer, Jill E Darling, Tania Gutsche, Margaret Gatz
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 5, p e34347 (2022)
BackgroundCognitive testing in large population surveys is frequently used to describe cognitive aging and determine the incidence rates, risk factors, and long-term trajectories of the development of cognitive impairment. As these surveys are increa
Externí odkaz:
https://doaj.org/article/39cb8bc6fa094654b182539d76707587
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Body mass index (BMI) is associated with cognitive abilities, but the nature of the relationship remains largely unexplored. We aimed to investigate the bidirectional relationship from midlife through late-life, while considering sex differe
Externí odkaz:
https://doaj.org/article/189e7b941ca14b29b437a229f2eaf494
Autor:
Diana Younan, Xinhui Wang, Joshua Millstein, Andrew J Petkus, Daniel P Beavers, Mark A Espeland, Helena C Chui, Susan M Resnick, Margaret Gatz, Joel D Kaufman, Gregory A Wellenius, Eric A Whitsel, JoAnn E Manson, Stephen R Rapp, Jiu-Chiuan Chen
Publikováno v:
PLoS Medicine, Vol 19, Iss 2, p e1003893 (2022)
BackgroundLate-life exposure to ambient air pollution is a modifiable risk factor for dementia, but epidemiological studies have shown inconsistent evidence for cognitive decline. Air quality (AQ) improvement has been associated with improved cardiop
Externí odkaz:
https://doaj.org/article/64c248c6b1cc4ef28013c7ad068bf88e
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background While a high body mass index (BMI) in midlife is associated with higher risk of dementia, high BMI in late-life may be associated with lower risk. This study combined genetic designs with longitudinal data to achieve a better unde
Externí odkaz:
https://doaj.org/article/5beb45c3a16b4010941db29df0b57d3c
Autor:
Angela R Garcia, Caleb Finch, Margaret Gatz, Thomas Kraft, Daniel Eid Rodriguez, Daniel Cummings, Mia Charifson, Kenneth Buetow, Bret A Beheim, Hooman Allayee, Gregory S Thomas, Jonathan Stieglitz, Michael D Gurven, Hillard Kaplan, Benjamin C Trumble
Publikováno v:
eLife, Vol 10 (2021)
In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low ca
Externí odkaz:
https://doaj.org/article/0a3db5e60d954d4f846826abf855dc08
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction To study if declining cognition drives weight loss in preclinical dementia, we examined the longitudinal association between body mass index (BMI) and cognitive abilities in individuals who did or did not later develop dementia.
Externí odkaz:
https://doaj.org/article/b48a8a49747d4905a699f22b5cee5710